DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hex-C and hk1

DIOPT Version :9

Sequence 1:	NP_524674.1	Gene:	Hex-C / 44008	FlyBaseID:	FBgn0001187	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_001096201.1	Gene:	hk1 / 100124752	XenbaseID:	XB-GENE-944850	Length:	917	Species:	Xenopus tropicalis

Alignment Length:	459	Identity:	204/459 - (44%)
Similarity:	297/459 - (64%)	Gaps:	24/459 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EVRELMQPFVLSDYQVQEVYSRFCLEVARGLKRSTHPQANVKCFPTYVQDLPTGDEMGKYLALDL 69
            ::.|.::.|.||..|:.||..|..:|:..||::.||..|.||..||||:..|.|.|.|.:|||||
Frog   469 QIDETLEEFKLSREQLLEVKRRMRIEIENGLRKKTHESAKVKMLPTYVRSTPDGTENGDFLALDL 533

  Fly    70 GGTNFRVLLVSLKGHHDATVD--SQIYAVPKDLMVGPGVDLFDHIAGCLAKFVEKHDMKTAYLPL 132
            ||||||||||.::.....||:  ::|||:|.|:|.|.|.:||||||.|::.|::...:|.|.|||
Frog   534 GGTNFRVLLVKIRSGKRRTVEMHNKIYAIPIDVMQGTGEELFDHIAHCISDFLDYMGIKGARLPL 598

  Fly   133 GFTFSFPCVQLGLKEGILVRWTKGFDCAGVEGEDVGRMLHEAIQRRGDADIAVVAILNDTTGTLM 197
            ||||||||:|..|..||||.|||||.....|||||..:|.|.|:||.:.|:.||||:|||.||:|
Frog   599 GFTFSFPCMQTSLDAGILVTWTKGFKATDCEGEDVVNLLREGIKRREEFDLDVVAIVNDTVGTMM 663

  Fly   198 SCAHRNADCRVGVIVGTGCNACYVEDVENVDLLRADFKKTKRSVIVNAEWGAFGEGGQLDFVRTE 262
            :||:.:.:|.:|:|||||.||||:|:.:|::::..|    :..:.||.||||||:.|.||.:||.
Frog   664 TCAYEDPNCEIGLIVGTGSNACYMEETKNIEMVDGD----QGRMCVNMEWGAFGDNGCLDDIRTV 724

  Fly   263 YDREVDEKSLNRSEQLFEKMTAGMYLGNLVRLVLLRALERKLIFKQSSRRPEFASVLQRNEEVFE 327
            ||:.||:.|||..:|.:|||.:|||||.:||.:|:...:|..:|     |.:.:..| :...:||
Frog   725 YDKAVDDLSLNSGKQRYEKMISGMYLGEIVRNILIDFTKRGFLF-----RGQISEAL-KTTSIFE 783

  Fly   328 TRYISEIEDDSFPEFASTRKIVKNLFGLEKASVEDCQTLRYICECVAKRAATLVAIGVSGLVNRT 392
            |:::|:||.|.. .....|.|::.| || .::.:|...::.:|..|::|||.:...|::.:|::.
Frog   784 TKFLSQIESDRL-ALLQVRSILQQL-GL-NSTCDDSIIVKEVCGAVSRRAAQVCGAGMAAVVDKI 845

  Fly   393 SNRR------VIVGMDGSVYRYHPKFDAYMRQTLQKLVKADK-EWDIMLSEDGSGRGAALVAAVA 450
            ...|      |.||:||::|:.||.|...|.||::.|  |.| ....:|||||||:||||:.|||
Frog   846 RENRGLDHLDVTVGVDGTLYKLHPHFSKIMHQTVKDL--APKCNVSFLLSEDGSGKGAALITAVA 908

  Fly   451 SKTK 454
            .:.:
Frog   909 CRLR 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-C	NP_524674.1	Hexokinase_1	5..200	CDD:278764	102/196 (52%)
		PTZ00107	13..454	CDD:240270	203/449 (45%)
		Hexokinase_2	207..449	CDD:281689	96/248 (39%)
hk1	NP_001096201.1	PTZ00107	12..460	CDD:240270
		Hexokinase_1	469..667	CDD:376323	103/197 (52%)
		Hexokinase_2	673..907	CDD:377112	96/248 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2527
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H100530
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm9451
Panther	1	1.100	-	-	O	PTHR19443
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.110