Protein Alignment IQSEC3 and iqsec3a

DIOPT Version :10

• Sequence 1: NP_001164209.1
• Gene: IQSEC3 / 440073
• HGNCID: 29193
• Length: 1182
• Species: Homo sapiens
• Sequence 2: XP_009298725.2
• Gene: iqsec3a / 797355
• ZFINID: ZDB-GENE-041210-343
• Length: 1285
• Species: Danio rerio
• Alignment Length: 1356
• Identity: 742/1356 - (54%)
• Similarity: 856/1356 - (63%)
• Gaps: 245/1356 - (18%)

Human     1 MESLLENPVRAVLYLKELTAIVQNQQSLIHTQRERIDELERRLDELSAENRSL---WEHQQLLQA 62
            |||||:||::|||||||||.|||||||||.|||:|||||||::::|..|||.|   .:||.....
Zfish     1 MESLLDNPMKAVLYLKELTTIVQNQQSLIQTQRQRIDELERKVEDLIGENRQLKDPHQHQHYHPH 65

Human    63 QPPPGLVPPSSAPLPAAPATAPAAAARAQEPLQDQGQRSAAAPHPAPDRPPRQHHGQLLEQPQRG 127
            ...|.  ||:|:|.||......:.:....:|...|.|..:..|.|.|..|  .||.|.|:.....
Zfish    66 HHHPS--PPTSSPHPAVHPHQHSGSHGQTQPQLPQQQHPSKQPQPQPAAP--IHHPQHLQLVPTS 126

Human   128 PGSRAHTPQSPHKHLGTQGAVTDKEKERPPSCCAAAGALLQHKSPSALGKGV-LSRRPENETVLH 191
            |.:...:..||      :.|..||   :.|||.:     |..::||.|.:.| |:|:|||:||||
Zfish   127 PPTLKASQSSP------ESADDDK---KSPSCKS-----LVPQTPSTLCRSVGLARKPENQTVLH 177

Human   192 QFCCPAAD-------AC---------------SDLASQSDG----SCTQA--------------- 215
            ||||||.|       ||               |.:||.|.|    |..|:
Zfish   178 QFCCPAPDAPESDSQACVPSEEPPLPSSIATPSPVASPSHGVTPTSAPQSEVQVEHHVAESTVTS 242

Human   216 ---GGGMEDSVVAAAAVAAGRPSAHAPKAQAQELQEEEER------------------------P 253
               |||..|. ....|...|.......:.:|:|:.:|||:                        |
Zfish   243 INEGGGDGDR-DGGDAQEKGSAEVEKEEVRAEEIVQEEEKTQTQPPQPIQEEVKKGTEEQEKETP 306

Human   254 GAGAASPRAGPQHKASPGRQQPALATALCPHAPAASDYELSLDLKNKQIEMLEHKYGGHLVSRRA 318
            ..|:...||...|.|||.|.|   ....|.|: ..|||||||||||||||||||||||||:||||
Zfish   307 STGSTGRRASLHHTASPIRVQ---RNGACSHS-TTSDYELSLDLKNKQIEMLEHKYGGHLISRRA 367

Human   319 ACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISLRKVRSPTAESLAAEKALMEGYGLVGLPLVR 383
            ||.||||||||||||||||||||||||||||||||||||....|.::||:||.||..|..:||||
Zfish   368 ACKIQTAFRQYQLSKNFEKIRNSLLESRLPRRISLRKVRVQNTEGISAERALAEGCNLTSIPLVR 432

Human   384 SPSLPPTFAGTLTELEDSFTEQVQSLAKSIDDALSTWSLKTMCSLRESGAYQL-HQALQAAAGPP 447
            |||||.|..||||:|||||.|||||||||||||||.||:||||||:|.|.||. .:|...|.|..
Zfish   433 SPSLPTTVGGTLTDLEDSFNEQVQSLAKSIDDALSNWSMKTMCSLQEGGTYQFSSEAFSTAGGKS 497

Human   448 GLEAEGRAPESAGPGPGDDAAET--PGLP--PA--HSGT---------------LMMAFRDVTVQ 491
            ||                  |||  .|.|  |:  ||||               |||||||||||
Zfish   498 GL------------------AETVKKGSPMDPSTFHSGTGQVDSLENVAQSASKLMMAFRDVTVQ 544

Human   492 IANQNISVS-----SSTALSVANCL--GAQTVQAPAEPAAGKAEQGETSGREAPEAPAVGREDAS 549
            |.:||..:|     |||::|:.||:  ||...::|.:|..          .:..|.|...:....
Zfish   545 IDSQNFRMSSSVMESSTSVSLGNCIQQGAIITESPQQPKI----------NDVKEQPQQRQPSTF 599

Human   550 AEDSCA---EAAASGAADG-ATAPKTEEE-----------EEEE--------------------E 579
            .||..:   |..|....|| ..||...||           |::|                    |
Zfish   600 LEDPVSPPLEQDAEEVPDGDFPAPPPSEEVLGEDVLPLELEKQEVPQPTIPAQTAITSETLSPPE 664

Human   580 TAEV----------GRGAEAEAGD--LEQLSSSSTSTKSAKSGSEASASASKDALQAMILSLPRY 632
            .||.          .:..|::..|  .||:||||||| ||:|.||.|   ||:||||||||||||
Zfish   665 VAETPVTPIVEVLEAKHIESDTADNSSEQMSSSSTST-SAQSASEVS---SKEALQAMILSLPRY 725

Human   633 HCENPASCKSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLS 697
            |||||.||||||||||.:|||||||||||||||||||:|||||||||||||||||||||||||||
Zfish   726 HCENPTSCKSPTLSTDIMRKRLYRIGLNLFNINPDKGLQFLISRGFIPDTPIGVAHFLLQRKGLS 790

Human   698 RQMIGEFLGNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRY 762
            |||||||||||||.||||||||||||||||.||||||||||||||||||||||||||||||||||
Zfish   791 RQMIGEFLGNSKKPFNRDVLDCVVDEMDFSGMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRY 855

Human   763 CMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELV 827
            |||||::|||||||||||||||||||||||||||||||||||:|||||||||||||||||||::|
Zfish   856 CMCNPDIVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMLLEDFIRNLRGVDDGADIPRDMV 920

Human   828 VGIYERIQQKELKSNEDHVTYVTKVEKSIVGMKTVLSVPHRRLVCCSRLFEVTDVNKLQKQAAHQ 892
            ||||||||.:||:|||||||||||||:|||||||||||||||||||||||||||:||.|||||||
Zfish   921 VGIYERIQLRELRSNEDHVTYVTKVEQSIVGMKTVLSVPHRRLVCCSRLFEVTDINKAQKQAAHQ 985

Human   893 REVFLFNDLLVILKLCPKKKSSSTYTFCKSVGLLGMQFQLFENEYYSHGITLVTPLSGSEKKQVL 957
            ||||||||||||||||||||||:.|||||::|||||||.||||||:.|.:|:|:|.|||||||||
Zfish   986 REVFLFNDLLVILKLCPKKKSSAAYTFCKTMGLLGMQFHLFENEYFPHAMTIVSPCSGSEKKQVL 1050

Human   958 HFCALGSDEMQKFVEDLKESIAEVTELEQIRIEWELEKQQGTKTLSFKPCGAQGDPQSKQGSPTA 1022
            :|||..::|:.|||||||||||||:|:||||||||||||||.||...|..|.|.:.:.:||||:.
Zfish  1051 NFCAQNAEELLKFVEDLKESIAEVSEMEQIRIEWELEKQQGAKTHPIKSNGTQLELRGRQGSPSG 1115

Human  1023 KREAALRERPAESTVEVSIHNRLQTSQHNSGLGAERGAPVPPPDL-----QPSPPRQQTPPLPPP 1082
            |::..: .:...:.:||||||||||.|.|:       ||:.|.:.     |..|.:|  |||...
Zfish  1116 KQDLNI-SQSGLNAIEVSIHNRLQTFQLNA-------APLSPENAAHLNHQREPIQQ--PPLQRA 1170

Human  1083 PPTP-------------PGTLVQCQQIVKVIVLDKPCLARMEPLLSQALSCY--------TSSSS 1126
            .||.             |.||:|||||||||||||.....:|..|||:.:.:        |...|
Zfish  1171 SPTTSYSYHPVALTELRPDTLIQCQQIVKVIVLDKGGHGHVEAFLSQSPTHHQLIQSVVTTPVHS 1235

Human  1127 DSCGSTPLGGPGSPVKVTHQPPLPPPPPPYNHPHQFCPPGSLLHGHRYSSGSRSLV 1182
            ...|.:..|..||      ||||||||||||||||:.||...:...|..|||.||:
Zfish  1236 PDDGDSHGGNDGS------QPPLPPPPPPYNHPHQYIPPDPRISLQRTPSGSHSLM 1285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IQSEC3	NP_001164209.1	bZIP	<32..63	CDD:269834	16/33 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	62..157		24/94 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	230..275		15/68 (22%)
		LGT	<444..553	CDD:469786	41/136 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	444..479		10/40 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..616		35/141 (25%)
		Sec7	651..839	CDD:460178	177/187 (95%)
		IQ_SEC7_PH	861..990	CDD:465120	105/128 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1002..1090		32/105 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1121..1182		29/68 (43%)
iqsec3a	XP_009298725.2	None