Protein Alignment IQSEC3 and siz

DIOPT Version :10

• Sequence 1: NP_001164209.1
• Gene: IQSEC3 / 440073
• HGNCID: 29193
• Length: 1182
• Species: Homo sapiens
• Sequence 2: NP_730594.1
• Gene: siz / 40327
• FlyBaseID: FBgn0026179
• Length: 1325
• Species: Drosophila melanogaster
• Alignment Length: 1244
• Identity: 376/1244 - (30%)
• Similarity: 525/1244 - (42%)
• Gaps: 344/1244 - (27%)

Human    29 IHTQRERIDELER-------RLDELSAE-NRSLWEHQQL-LQAQ---------------PPPGLV 69
            :|.....:|||.|       ::.|||.| :|.|.|...| |:..               |...|.
  Fly    71 VHAMPYNVDELLRENNALHAKIKELSLERDRLLCEVSNLRLELDMSELKRLPVDLDDNFPQKSLE 135

Human    70 PPSSAPLPAAPATAPAAAARAQEPLQDQG-----------------QRSAAAPHPAPDRPPRQHH 117
            ...|.....|.|..|.:|..:  ...|.|                 ..|||..:||      |.|
  Fly   136 RSGSTQYELAGAQQPGSANAS--TCTDSGSVGGYVYLQNHYAPGAHSSSAAINYPA------QQH 192

Human   118 GQLLEQPQRGP-----GSRAHTPQSPHKHLGTQGAVTDKEKERPPSCCAAAGALLQHKSPSALGK 177
            .|::.|.|:.|     ..:.|..|..|.|.                  ..||..:|   .:|.|.
  Fly   193 PQMVYQIQQYPTCHQQQQQQHLQQQQHLHQ------------------TGAGHYMQ---VTATGG 236

Human   178 GVLSRRPENETVLHQFCCPAADACSDLASQSDGSCTQAGGGMEDSVVAAAAVAAGRPS-AHAPKA 241
            |    :..:..:||                ..|......||.  .|:|.:.|..|..| |.:...
  Fly   237 G----QYHHHHMLH----------------GHGHHAHHHGGA--VVIAGSGVGTGLGSGATSVIM 279

Human   242 QAQELQEEEERPGAGAASPRAGPQHKASPGRQQPALATALCPHAPAASDYELSLDLKNKQIEMLE 306
            |.|:.|::::.            .||.:..|.    ...:.....|.|.||||.||..||||:||
  Fly   280 QHQQQQQQQQN------------MHKKNSIRN----GGDVLKRTRAQSAYELSQDLLEKQIELLE 328

Human   307 HKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISLRKVRSPTAESLAAEKA-L 370
            .|||| :.:|.||.|||.|||.|.:.|.|..|   ...::..:|:|.|.|.:.::..||.|.| .
  Fly   329 RKYGG-VRARNAAVTIQRAFRHYMMVKKFASI---TAMAKAEKRLSRRMVVTASSLGLAEEGASS 389

Human   371 MEGYG--------------------------LVGLPLVRSPSL---PPTFAGTLTE---LEDSFT 403
            ...||                          :.|.....||.|   |||.:.::.|   |:.|..
  Fly   390 SSAYGSATESQLTEQQQQQQAQQQQQPRVTIMAGPAGAASPGLSRTPPTRSLSMRERRQLDCSPI 454

Human   404 EQVQSLAKSIDDALSTWSLKTMCS-------------------LRESGAYQL------HQALQAA 443
            .:.||.|.....:.||.|...:.|                   |.:..||..      |....|:
  Fly   455 PRSQSGASPASISSSTVSTSALASHPHVNLLHAAEPHYYNAQALPQGAAYYTSYHGSPHDLSYAS 519

Human   444 AGPPGLEA-----EGRAPE-------------------------------SAGPGPGDDAAETPG 472
            :....|.|     .|.:|.                               |.|.|.|......|.
  Fly   520 SADTSLNASWVNTSGHSPHTPYYSAAQIYMRPKGGSTTPTPSCSGSTGSGSGGSGSGSSKKVPPE 584

Human   473 LP-----------------------------------PAHSGTLMMAFRDVTVQIANQNISVSSS 502
            :|                                   .|.:|:|      .:||.:..:.||:|:
  Fly   585 VPKRTSSITAQQQTQLLLLQRQTPPPPSLLRTNGLCKTAENGSL------TSVQSSGSDSSVTSA 643

Human   503 TALSVANCLGAQTVQAPAEPAAGKA-------------EQGETSGREAPEAPAVGREDASAEDSC 554
            .. ::.:.||:....:|.....|.|             ..|..||.....|...|...|..:.:.
  Fly   644 ER-NLNSDLGSDRSNSPHTWKRGTALNSSQQFSTHSADSAGAVSGGGVGVAGGAGVYAAQMQAAV 707

Human   555 AEAAASG----AADGA-----TAPKTEEEEEEEETAEVGRGAEAEAGDLEQLSSSSTSTKSAKSG 610
            |.|.|:|    |.|.|     :|.:.|:.|:::...:..:.|.|.||..:....|
  Fly   708 AAATAAGGMPPADDHAISSHTSAAQYEQHEQQQHEQQQLQAAAAAAGVAQNYKMS---------- 762

Human   611 SEASASASKDALQAMILSLPRYHCENPASCKSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLIS 675
                                                 :|:|||.||:||||||..|:|||.:||.
  Fly   763 -------------------------------------ETIRKRQYRVGLNLFNKKPEKGITYLIR 790

Human   676 RGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQA 740
            |||:.:||.|||.||:.|||||||||||:|||.:.|||..||.|...|:|.|..::|.|||||||
  Fly   791 RGFLENTPQGVARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQA 855

Human   741 HIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMM 805
            :.|:.|||||:|||:|.||||||.||.::|.:..:.||||:||||||:||||:::||:||:|:|.
  Fly   856 YFRMPGEAQKIERLMEIFSQRYCECNADIVGRLRSSDTIFVLAFAIIMLNTDLHTPNLKPERRMR 920

Human   806 LEDFIRNLRGVDDGADIPRELVVGIYERIQQKELKSNEDHVTYVTKVEKSIVGMKTVLSVPHRRL 870
            :||||:||||:||..||.:::::|||:|::..|.|...||||.|.||:.:|||.|..|::|||||
  Fly   921 VEDFIKNLRGIDDCHDIDKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQATIVGKKPNLALPHRRL 985

Human   871 VCCSRLFEVTDVNKLQKQAAHQREVFLFNDLLVILKLCPKKKSSSTYTFCKSVGLLGMQFQLFEN 935
            ||..||:|:.||||.::...||||||||||||||.|:..|||:|.||||..|..|.|....|.:.
  Fly   986 VCYCRLYEIPDVNKKERPGVHQREVFLFNDLLVITKIFSKKKTSVTYTFRNSFPLCGTVVTLLDM 1050

Human   936 EYYSHGITLVTPLSGSEKKQVLHFCALGSDEMQKFVEDLKESIAEVTELEQIRIEWELEKQQ--- 997
            ..|...|.|...:.|   |.::.|.|....:..||.|||||||:|:.|:|.:|||.|||:|:
  Fly  1051 PNYPFCIQLSQKVDG---KILITFNARNEHDRCKFAEDLKESISEMDEMESLRIEAELERQKSAR 1112

Human   998 ------------GTKTLSFKPCG-AQGDPQSKQGSPTAKREAALRERPAESTVEVSIHNRL--QT 1047
                        |...:...||. .||...|.:.:|.:...:...:|.|.|...:.:|.:.  :.
  Fly  1113 NRAPGNAENRDSGVADVEVCPCPYQQGSQASGEQAPNSADNSQQLKRSALSNSLLDMHEQFGNEK 1177

Human  1048 SQHNSGLGA 1056
            .|....:|:
  Fly  1178 PQRRGSVGS 1186

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IQSEC3	NP_001164209.1	bZIP	<32..63	CDD:269834	13/39 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	62..157		24/131 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	230..275		9/45 (20%)
		LGT	<444..553	CDD:469786	29/192 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	444..479		11/105 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..616		23/116 (20%)
		Sec7	651..839	CDD:460178	113/187 (60%)
		IQ_SEC7_PH	861..990	CDD:465120	62/128 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1002..1090		12/58 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1121..1182
siz	NP_730594.1	Sec7	766..954	CDD:460178	113/187 (60%)
		PH_IQSEC	981..1108	CDD:270128	66/129 (51%)