DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fad2 and Scd3

DIOPT Version :9

Sequence 1:	NP_651966.2	Gene:	Fad2 / 44006	FlyBaseID:	FBgn0029172	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_077770.1	Gene:	Scd3 / 30049	MGIID:	1353437	Length:	359	Species:	Mus musculus

Alignment Length:	294	Identity:	151/294 - (51%)
Similarity:	210/294 - (71%)	Gaps:	8/294 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 KLELVWVNIVLFVILHISSLYGVWLLFTSATWTTVVLFWPTVVVTILGVSGGAHRLWAHRTFKAN 102
            |||.||.||:|..:||:.:|||:.|:.:...:|.:..| ...|::|.|:..|.||||:|||:||.
Mouse    68 KLEYVWRNIILMALLHVGALYGITLVPSCKLYTCLFAF-VYYVISIEGIGAGVHRLWSHRTYKAR 131

  Fly   103 TPLKLIFLFLNTLAFQDAVYYWARDHRVHHKYTETDADPYNSQRGWFFAHIGWLCCRKHPEVVEK 167
            .||::..:..||:|||:.||.||||||.|||::||.|||:||:||:||:|:|||..||||.|.||
Mouse   132 LPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEK 196

  Fly   168 GKQIDLSDLEADPLIMFQKKYY---LLLMPIICFVLPTVLPMYLWGESLNVSWHVMALLRWCLSL 229
            |.::|:|||:|:.|:|||::||   :|||   ||:|||::|.|.|||:...|::|..|||:.:.|
Mouse   197 GGKLDMSDLKAEKLVMFQRRYYKPGILLM---CFILPTLVPWYCWGETFLNSFYVATLLRYAVVL 258

  Fly   230 NLIWTVNSSAHMHGMRPYDKNICPVDQGFLIFFRVGEGYHNYHHVFPWDYKSAELGKYSQDVTTK 294
            |..|.|||:||::|.|||||||.|.....:....:|||:|||||.||:||.::|. ::..:.||.
Mouse   259 NATWLVNSAAHLYGYRPYDKNIDPRQNALVSLGSMGEGFHNYHHAFPYDYSASEY-RWHINFTTF 322

  Fly   295 FIEFMAYLGWAYDLKSVSLDLVKQRVQRSGDGSH 328
            ||:.||.||.|||.|.||...|..|::|:|||||
Mouse   323 FIDCMAALGLAYDRKRVSKATVLARIKRTGDGSH 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fad2	NP_651966.2	Delta9-FADS-like	68..309	CDD:239582	126/243 (52%)
Scd3	NP_077770.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		Delta9-FADS-like	97..337	CDD:239582	126/244 (52%)
		FA_desaturase	102..306	CDD:278890	110/207 (53%)
		Histidine box-1. /evidence=ECO:0000305	120..125		4/4 (100%)
		Histidine box-2. /evidence=ECO:0000305	157..161		2/3 (67%)
		Histidine box-3. /evidence=ECO:0000305	298..302		3/3 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845368
Domainoid	1	1.000	56	1.000	Domainoid score	I10942
eggNOG	1	0.900	-	-		E1_COG1398
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H137370
Inparanoid	1	1.050	369	1.000	Inparanoid score	I2119
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63267
OrthoDB	1	1.010	-	-		D296120at33208
OrthoFinder	1	1.000	-	-		FOG0000495
OrthoInspector	1	1.000	-	-		mtm8712
orthoMCL	1	0.900	-	-		OOG6_100468
Panther	1	1.100	-	-	O	PTHR11351
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X207
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770