DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ScsbetaG and SUCLG2

DIOPT Version :9

Sequence 1:	NP_001286941.1	Gene:	ScsbetaG / 44001	FlyBaseID:	FBgn0029118	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001171070.1	Gene:	SUCLG2 / 8801	HGNCID:	11450	Length:	440	Species:	Homo sapiens

Alignment Length:	362	Identity:	213/362 - (58%)
Similarity:	268/362 - (74%)	Gaps:	1/362 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RNLNLLEFQSKDLLQKYGVAIQQFKVLNNSKADAEVVKTFECPEYVVKAQILAGGRGKGTFDNGF 85
            |.|||.|:|||.|:...||.:|:|.|.:.:....|..|.....|.|:||||||||||||.|::|.
Human    36 RWLNLQEYQSKKLMSDNGVRVQRFFVADTANEALEAAKRLNAKEIVLKAQILAGGRGKGVFNSGL 100

  Fly    86 KGGVHITTNKSEVLSLTQQMIGNRLITKQTPKSGILVNKVMVARSINITRETYLCILLDREHNGP 150
            |||||:|.:.:.|..|.:||||..|.||||||.|:.|||||||.:::|:|||||.||:||..|||
Human   101 KGGVHLTKDPNVVGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGP 165

  Fly   151 VLIASPAGGMDIEAVAEETPEKIKTVPLDIGKPIPESTLLEVAKFLEFKGDSVKRCAEEIQKLYT 215
            ||:.||.||:|||.||...||.|....:||.:.|.:|....:|:.|.|.|....:.|::|.|||.
Human   166 VLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDSQAQRMAENLGFVGPLKSQAADQITKLYN 230

  Fly   216 LFKAVDAVQIEINPLAETDKGEVISVDAKLNFDDNAQFRQKDIFSMDVTEEESDPREVEAAKYNL 280
            ||..:||.|:|:||..||.:|:|:..|||:||||||:|||||||:|| .:.|::|.|.|||||:|
Human   231 LFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMD-DKSENEPIENEAAKYDL 294

  Fly   281 NYVAMDGNIGCLVNGAGLAMATMDIIKLNGGEPANFLDVGGGVREDQVAKAFEILTADPKVKGIL 345
            .|:.:||||.|.||||||||||.|||.||||:||||||:||||:|.||.:||::|||||||:.||
Human   295 KYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQVYQAFKLLTADPKVEAIL 359

  Fly   346 VNVFGGIVNCATIANGIVAASKKLQLNVPLVVRLEGT 382
            ||:||||||||.|||||..|.::|:|.||||||||||
Human   360 VNIFGGIVNCAIIANGITKACRELELKVPLVVRLEGT 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ScsbetaG	NP_001286941.1	sucC	24..416	CDD:234813	211/359 (59%)
		ATP-grasp_4	24..232	CDD:302634	105/207 (51%)
		Ligase_CoA	292..412	CDD:278948	69/91 (76%)
SUCLG2	NP_001171070.1	sucC	39..396	CDD:234813	209/357 (59%)
		ATP-grasp_2	39..247	CDD:285620	105/207 (51%)
		Ligase_CoA	306..>396	CDD:278948	67/89 (75%)
		Substrate binding, shared with subunit alpha. /evidence=ECO:0000255\|HAMAP-Rule:MF_03221	365..367		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143764
Domainoid	1	1.000	201	1.000	Domainoid score	I3028
eggNOG	1	0.900	-	-		E1_COG0045
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2854
Inparanoid	1	1.050	455	1.000	Inparanoid score	I1596
Isobase	1	0.950	-	0	Normalized mean entropy	S484
OMA	1	1.010	-	-		QHG60702
OrthoDB	1	1.010	-	-		D342254at33208
OrthoFinder	1	1.000	-	-		FOG0001148
OrthoInspector	1	1.000	-	-		oto91609
orthoMCL	1	0.900	-	-		OOG6_100409
Panther	1	1.100	-	-	LDO	PTHR11815
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2824
SonicParanoid	1	1.000	-	-		X3948
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750