DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ScsbetaG and acly-2

DIOPT Version :9

Sequence 1:	NP_001286941.1	Gene:	ScsbetaG / 44001	FlyBaseID:	FBgn0029118	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_506267.1	Gene:	acly-2 / 179795	WormBaseID:	WBGene00007150	Length:	1099	Species:	Caenorhabditis elegans

Alignment Length:	439	Identity:	106/439 - (24%)
Similarity:	164/439 - (37%)	Gaps:	101/439 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 EFQSKDLLQKY----GV--AIQQFKVLNNSKADAEVVKTFEC----PEYVVKAQILAGGRGKGTF 81
            |...|::|.||    |:  |...|.|....|. ::|...:|.    .:.|:|...|...|||
Worm     8 ELSGKEVLYKYFESTGIVSAPHAFHVKAGDKF-SDVAAKYEWLAQDNKGVIKPDQLIKRRGK--- 68

  Fly    82 DNGFKGGVHI------------TTNKSEVLSLTQQMIGNRLITKQTPKSGILVNKVMVARSINIT 134
                .|.|.|            |.|....:..|:    .||.|        .:.:...|.:.|
Worm    69 ----LGLVKIGSPKELEAWFGKTANSYVKVGQTE----GRLHT--------FIVEPFCAHTEN-- 115

  Fly   135 RETYLCILLDREHNGPVLIASPAGGMDIEAVAEETPEKIKTVPL-DIGKPIPESTLLEVAKFLEF 198
            .|.|:.|..:|..:  |::....||:||..|.|:.......|.| |....|.|..|
Worm   116 EEMYIAIYSERCRD--VIMFYEQGGVDIGDVEEKARSVHVPVQLDDNAMSISEREL--------- 169

  Fly   199 KGDSVKRCAEE------IQKLYTLFKAVDAVQIEINPLAETDKGEVISVDAKLNFDDNAQFRQKD 257
             |..:..|:::      ::.||..:||:....:||||...|: |::..:|.....|:.|.|...|
Worm   170 -GVLLGPCSDKDDIRKFVRSLYEAYKALHFTYLEINPFVLTN-GKIHILDLAAKLDETASFLCSD 232

  Fly   258 -------------------IFSMDVTEEE---SDPREVEAAKYNLNYVAMDGNIGCLVNGAGLAM 300
                               .|..|:|.||   ||......|...|..:...|.:..:|.|.|.::
Worm   233 KWSGRNASARIAPTLEFPAPFGRDLTSEEQYISDMDAKTGASLKLTILNRKGRVWTMVAGGGASV 297

  Fly   301 ATMDIIKLNGG--EPANFLDVGGGVREDQV---AKA-FEILT-ADPKVKGILVNVFGGIVNCATI 358
            ...|.:...||  |.||:.:..|...|.|.   ||. ..::| ..|:..|.::.:.|.|.|...:
Worm   298 VFTDTVCDLGGSSELANYGEYSGDPSEAQTYEYAKTILSVMTEGAPRPDGKVLIIGGSIANFTNV 362

  Fly   359 A---NGIVAA-----SKKLQLNVPLVVRLEGTNVNQAREILKNSGLPIQ 399
            |   .|||.|     .|..:.||.:.||..|.|..:....:|::...::
Worm   363 AKTFGGIVRAFETFIDKLKEHNVSIYVRRGGPNYQEGLRRVKDAATKLE 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ScsbetaG	NP_001286941.1	sucC	24..416	CDD:234813	106/439 (24%)
		ATP-grasp_4	24..232	CDD:302634	56/233 (24%)
		Ligase_CoA	292..412	CDD:278948	33/123 (27%)
acly-2	NP_506267.1	PLN02235	1..431	CDD:177879	106/439 (24%)
		ATP-grasp_4	8..208	CDD:302634	56/233 (24%)
		Citrate_bind	258..433	CDD:292732	41/154 (27%)
		PLN02522	488..1093	CDD:178137
		CoA_binding	491..596	CDD:280747
		Ligase_CoA	656..781	CDD:278948
		CCL_ACL-C	852..1092	CDD:99854
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810