Protein Alignment Spt6 and supt6h

DIOPT Version :10

• Sequence 1: NP_651962.2
• Gene: Spt6 / 44000
• FlyBaseID: FBgn0028982
• Length: 1831
• Species: Drosophila melanogaster
• Sequence 2: XP_012812907.1
• Gene: supt6h / 780122
• XenbaseID: XB-GENE-990369
• Length: 1728
• Species: Xenopus tropicalis
• Alignment Length: 1888
• Identity: 880/1888 - (46%)
• Similarity: 1189/1888 - (62%)
• Gaps: 224/1888 - (11%)

  Fly     3 EFLDSEAEESE-EEEELDVNERKRLKKLKAAVSDSSEEEE------DDEERLREELKDLIDDNPI 60
            :|::||||||| |.||..|...|:..:     .|..||||      |::..||..:.|..|:..:
 Frog     2 DFVESEAEESEGEYEEGTVPNTKKFTE-----DDDEEEEEENPEDQDEQGNLRGFINDEDDEEDM 61

  Fly    61 EEDDGSGYDSDGVGS--GKKRKKHEDDDLDDRLEDDDYDLIEENLGVKVERRKRFKRLRRIHDNE 123
            ||||..|.:|.|...  |.|::||   ..||||||||:|||||||||||:|:| |:|:|::.|:|
 Frog    62 EEDDEGGSESGGSDEEVGHKKRKH---TFDDRLEDDDFDLIEENLGVKVKRQK-FRRVRKMSDDE 122

  Fly   124 SDGEEQHVDEGLVREQIAEQLFDENDESIGHRSER--------SHREADDYDDVDTESDADDFIV 180
            .:.||....|...:|.|||::|.:     |...||        :..|.:|.|| |.|||.|||||
 Frog   123 DEEEEDFGKEEHEKEAIAEEIFQD-----GEDEERRDVLDQPGAGPEDEDEDD-DEESDIDDFIV 181

  Fly   181 DDNGRPIAEKK-KKRRPIFTDASLQEGQDIFGVDFDYDDFSKYEEDDYEDDSEGDEYDEDLGVGD 244
            ||:|:|:.:.| :|:.|.:|||:|||.|:||||||||::|.||:    |||.|.:|||.:...||
 Frog   182 DDDGQPLKKPKWRKKLPGYTDAALQEAQEIFGVDFDYNEFEKYD----EDDEEMEEYDYEDDEGD 242

  Fly   245 -DTRVKKKKALKKKVVKKTIFDIYEPSELKRGHFTDMDNEIRKTDIPERMQLREVPVTPVPEGSD 308
             .|||:.||..||:|.:::||:|||||||:..|.||.|||||.||:|||.|||.:.|....:  |
 Frog   243 AATRVRPKKTAKKRVSRRSIFEIYEPSELESSHLTDQDNEIRTTDMPERFQLRTISVKSAED--D 305

  Fly   309 ELDLEAEWIYKYAFCKHTVSEQEKPESREK-------MRKPPTTVNKIKQTLEFIRNQQLEVPFI 366
            ||:.||||||:.||...|:|.||..:..|:       .||.|:|:.||::.|.|:|||..|||||
 Frog   306 ELEEEAEWIYRNAFATPTISLQETNDYLERGQVGSNFNRKGPSTIQKIREALNFMRNQHFEVPFI 370

  Fly   367 AFYRKEYVKPELNIDDLWKVYYYDGIWCQLNERKRKLKVLFEKMRQFQLDTLCADTDQPVPDDVR 431
            ||||||||:|||||:|||:|:.:|..|.||..||:.|..|||||:.:|.:.:.:|.|:|:.|.:|
 Frog   371 AFYRKEYVEPELNINDLWRVWQWDEKWTQLKLRKQNLIRLFEKMQAYQYEQISSDPDKPLADGIR 435

  Fly   432 LILDSDFERLADVQSMEELKDVHMYFLLNYSHELPRMQAEQRRKAIQERREAKARRQAAAAENGD 496
            .:...|.|||.||:||:|||||:.:|||.|..::|:||  ...|:.|:    |.:|.....|.|.
 Frog   436 ALDTVDMERLKDVKSMDELKDVYNHFLLYYGRDIPKMQ--NAAKSSQK----KMKRIPEEGEEGA 494

  Fly   497 DAAEAIVVPEPEDDDDPELIDYQLKQASNSSPYAVFRKAGICGFAKHFGLTPEQYAENLRDNYQR 561
            ||.|    .|.|....||     |||||....|::.:.||:.|.||.|||||||:.|||||:|||
 Frog   495 DAGE----QEEESSKGPE-----LKQASRRDMYSICQIAGLDGLAKKFGLTPEQFGENLRDSYQR 550

  Fly   562 NEITQESIGPTELAKQYLSPRFMTTDEVIHAAKYVVARQLAQEPLLRKTMREVYFDRARINIRPT 626
            :|..|....|.||||.|...:|.|.:.|:..|:|:||.|:|:|||:|:.:|:.:.:||::||.||
 Frog   551 HETEQFPAEPLELAKDYTCSQFTTPEAVLEGARYMVALQIAREPLVRQVLRQTFQERAKVNIIPT 615

  Fly   627 KNGMVLIDENSPVYSMKYVAKKPVSDLFGDQFIKLMMAEEEKLLEITF---LEEFEGNACANGTP 688
            |.|...|||....|:.||:..|||.:|..|.|:|:.:||||:||.|..   :::.||.
 Frog   616 KKGKKEIDEAHFAYAFKYLKNKPVKELRDDLFLKMCIAEEEQLLTIEICIDMKDVEGY------- 673

  Fly   689 GD--YVEESKALYQLDQFAKHVQEWNKLRAECVQLALQKWVIPDLIKELRSTLHEEAQQFVLRSC 751
            ||  |.||.|..|..|:|:..|||||:.|...::.||::::.|.:.|||::.|..||:.||::||
 Frog   674 GDQTYFEEIKQFYYRDEFSHQVQEWNRQRTLAIERALKQFLYPQMAKELKNKLVLEAKDFVIKSC 738

  Fly   752 TGKLYKWLKVAPYKP--QLPPDFGYEEWSTLRGIRVLGLAYDP--DHSVAAFCAVTTVEGDISDY 812
            :.|||.|||||.|:|  |:..|..:.|.:..:||||||:||..  ||.|  ||::...||:::|:
 Frog   739 SRKLYNWLKVASYRPDTQVEEDDDFMEENQGKGIRVLGMAYSSARDHPV--FCSLINGEGEVTDF 801

  Fly   813 LRLPNILKRKNSYNLEEKAQKLADLRKLSDFIKMKKPHIVVIGAESRDAQNIQADIKEILHELET 877
            ||||...||||::..:|:.:|..|:..|..|:..||||:|.|.:|:||||.:..|:|.::.|||.
 Frog   802 LRLPYFTKRKNAWREDERERKARDMETLKKFLISKKPHVVAIASENRDAQMMVEDVKRVVQELEQ 866

  Fly   878 SEQFPPIEVEIIDNELAKIYANSKKGESDFKEYPPLLKQAASLARKMQDPLVEYSQLCDADDEIL 942
            .:|...|.||::|||||.:|.||||.|:||::|||:|:||.|:||::||||:|::|:|..||:||
 Frog   867 GQQMSAIGVEMVDNELAVLYMNSKKSETDFRDYPPVLRQAVSIARRIQDPLIEFAQVCSTDDDIL 931

  Fly   943 CLRYHPLQERVPREQLLEQLSLQFINRTSEVGLDINLMVQNSRTINLLQYICGLGPRKGQALLKL 1007
            ||:.|||||.|.:|:||..|..:||||.:|||:|:|..:.:..|..|:||:||||||||..|||:
 Frog   932 CLKLHPLQEHVVKEELLNSLYCEFINRVNEVGVDVNRAIAHPYTQALIQYVCGLGPRKGAHLLKI 996

  Fly  1008 LKQSNQRLENRTQLVTVCHLGPRVFINCSGFIKIDTSSLGDSTEAYVEVLDGSRVHPETYEWARK 1072
            |||:|.||||||||||:||:||:|||||:||:||||:||||||::|:||||||||||||||||||
 Frog   997 LKQNNTRLENRTQLVTMCHMGPKVFINCAGFVKIDTNSLGDSTDSYIEVLDGSRVHPETYEWARK 1061

  Fly  1073 MAIDAMEYDD--EETNPAGALEEILESPERLKDLDLDAFAVELERQGFGSKSITLYDIRNELSCL 1135
            ||:||:|||:  |:.|||||||||||:|||||||||||||.||||||:|.|.|||||||.||||.
 Frog  1062 MAVDALEYDESAEDANPAGALEEILENPERLKDLDLDAFAEELERQGYGDKHITLYDIRAELSCR 1126

  Fly  1136 YKDYRTPYTKPSAEELFDMLTKETPDSFYVGKCVTAMVTGFTYRRPQGDQLDSANPVRLDSNESW 1200
            |||.||.|..|:.||:|:|||:|||::||:||.:|..|||..:|||||:..|.|  :|.|....|
 Frog  1127 YKDLRTTYRSPNPEEVFNMLTRETPETFYIGKLITCNVTGIAHRRPQGETYDQA--IRNDETGLW 1189

  Fly  1201 QCPFCHKDDFPELSEVWNHFDANACPGQPSGVRVRLENGLPGFIHIKNLSDRQVRNPEERVRVSQ 1265
            |||||.:|:||||||||||||:.:||||..||:.||:|.:.|||..|.:||:.|:.|||||:|..
 Frog  1190 QCPFCQQDNFPELSEVWNHFDSGSCPGQAIGVKTRLDNSVTGFIPTKFISDKAVKRPEERVKVGM 1254

  Fly  1266 MIHVRIIKIDIDRFSVECSSRTADLKDVNNEWRPRRDNYYDYVTEEQDNRKVSDAKARALKRKIY 1330
            .:|.||:||:|::|||:.:.||:||.|.||||:..:|.|||:.||..|:::..:.|.:. :|..|
 Frog  1255 TVHCRIMKINIEKFSVDLTCRTSDLMDKNNEWKLPKDTYYDFDTESADHKQEEEFKKKQ-QRTTY 1318

  Fly  1331 ARRVIAHPSFFNKSYAEVVAMLAEADQGEVALRPSSKSKDHLTATWKVADDIFQHIDVREEGKEN 1395
            .:||||||||.|.::.:...|:...|||:|.:|||||.::|||.||||.:.|:||:|||||||||
 Frog  1319 IKRVIAHPSFHNINFKQAEKMMETMDQGDVIIRPSSKGENHLTVTWKVCEGIYQHVDVREEGKEN 1383

  Fly  1396 DFSLGRSLWIGTEEFEDLDEIIARHIMPMALAARELIQYKYYKPNMVTGDENERDVMEKLLREEK 1460
            .||||.:|||..||||||||||||.:.|||..||:||.:||::    ..:..|:..:|:||.:.|
 Frog  1384 AFSLGSTLWINNEEFEDLDEIIARFVQPMASFARDLINHKYFQ----DCNNGEKKKLEELLIKTK 1444

  Fly  1461 ANDPKKIHYFFTASRAMPGKFLLSYLPKTKVRHEYVTVMPEGYRFRGQIFDTVNSLLRWFKEHWL 1525
            ...|..|.|:.:|.:.:||||||.|.|:.|.|.|||||.|||:|:|||||.|||.|.||||:|:.
 Frog  1445 KEKPTFIPYYISACKELPGKFLLGYQPRAKPRVEYVTVTPEGFRYRGQIFPTVNGLFRWFKDHYQ 1509

  Fly  1526 DPT--ATPASASASNLTPLHLMRPPPTISSSSQTSLGPQAPYSVT-------GSVTG-------G 1574
            ||.  .||:|:|.:. ||..:...|..|:.:..|......|.::|       .:|||       .
 Frog  1510 DPVPGITPSSSSRTR-TPASVNATPANINLADLTRAVNALPQNMTSQMFNAIAAVTGQHGQNPNA 1573

  Fly  1575 TPRSGISSAVGGGGSSAYSITQSITGYGTSGSSAPGAGVSSSHYGSSSTPSFGAINTP-YTPSGQ 1638
            ||....||..|.||                     |:|..||.|...:||:...:.|| .|||..
 Frog  1574 TPAQWASSQYGYGG---------------------GSGGGSSAYHVFATPAQQPVATPLMTPSYS 1617

  Fly  1639 --TPFMTPYTPHASQTPRYGHNVPSPSSQSSSSQRHHYGSSSGTGSTPRYHDMGGGGGGGVGGGG 1701
              ||.....||...|.|......|:|:.|||.||     |||.:.|:.|
 Frog  1618 YATPSQPITTPQYHQLPPSATPTPAPTPQSSHSQ-----SSSHSQSSSR---------------- 1661

  Fly  1702 GSNAYSMQPHHQQRAKEN----LDWQLANDAWARRRPQQHQSHQSYHAQQQHHHSQQQPHMGMSM 1762
                      |:|::|.|    :||....:.|.:.:..:.:.      |:|....:..|
 Frog  1662 ----------HRQQSKSNNHTAIDWGKMAEQWLQEKEAERRK------QKQRVTPRPSP------ 1704

  Fly  1763 NMGITMSLGRGTGGGGGGGYGSTPVNDYSTGGGHNRGMSSKASVRSTPRTNASPHSMNLGDATPL 1827
                                  :|:                  :.|||.:.|       ||||||
 Frog  1705 ----------------------SPM------------------IESTPMSVA-------GDATPL 1722

  Fly  1828 YDE 1830
            .||
 Frog  1723 LDE 1725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spt6	NP_651962.2	HTH_44	308..410	CDD:464230	59/108 (55%)
		Tex	565..1278	CDD:441786	395/723 (55%)
		RuvC-like	781..935	CDD:473878	77/155 (50%)
		HHH_5	939..1042	CDD:473956	65/102 (64%)
		SH2_2	1312..1522	CDD:464227	110/209 (53%)
supt6h	XP_012812907.1	HTH_44	<341..416	CDD:464230	45/74 (61%)
		Tex	558..1123	CDD:441786	310/573 (54%)
		YqgF	768..924	CDD:258777	77/157 (49%)
		HHH_7	928..1031	CDD:291309	65/102 (64%)
		S1	<1220..1275	CDD:197648	27/54 (50%)
		SH2_2	1300..1505	CDD:464227	109/209 (52%)