Protein Alignment Spt6 and SRBD1

DIOPT Version :10

• Sequence 1: NP_651962.2
• Gene: Spt6 / 44000
• FlyBaseID: FBgn0028982
• Length: 1831
• Species: Drosophila melanogaster
• Sequence 2: NP_060549.4
• Gene: SRBD1 / 55133
• HGNCID: 25521
• Length: 995
• Species: Homo sapiens
• Alignment Length: 1234
• Identity: 238/1234 - (19%)
• Similarity: 416/1234 - (33%)
• Gaps: 405/1234 - (32%)

  Fly   207 QDIFGVDFDYDDFSKYEEDDYEDDSEGDEYDEDLGVGDDTR---VKKKKALKKKVVKKTIFDIYE 268
            ||:...| ::..||:......|||.|...::....|....:   .|:.|..:...|||....|.:
Human    13 QDVVLKD-EFSSFSELSSASEEDDKEDSAWEPQKKVPRSRKQPPPKESKPKRMPRVKKNAPQISD 76

  Fly   269 PSELKRGHFTDMDNEIRKTDIPERMQLREVPVTPVPEGSDELDLEAEWIYKYAFCKHTVSEQEKP 333
            .||:          .:.|.::...:.:.:   |.:.:..::||              ||...:..
Human    77 GSEV----------VVVKEELNSSVAIAD---TALEDRKNKLD--------------TVQTLKTA 114

  Fly   334 ESREKMRKPPTTVNKIKQ-----------TLEFIRNQQLEVPFIAFYRKEYVKPELNIDD----- 382
            ::::|....|.||.:.|:           .||...|.. |.|..:.......|.|.|.||
Human   115 KTKQKCAAQPHTVRRTKKLKVEEETSKASNLEGESNSS-ETPSTSTVWGGTCKKEENDDDFTFGQ 178

  Fly   383 --LWKV---YYYDG----IWCQLNERKRKLKVLFEKMRQFQLDT-----LCA------DTDQPVP 427
              |.|:   .|..|    .....|..|.::::.::.::.....|     :||      :.|..:|
Human   179 SALKKIKTETYPQGQPVKFPANANSTKEEVEMNWDMVQVLSERTNIEPWVCANIIRLFNDDNTIP 243

  Fly   428 DDVR----LILDSDFERLADV-QSMEELKDVHMYFLLNYSHELPRMQAEQRRKAIQE-RREAKAR 486
            ..:|    ||.:.|.:.|.:| |::|||:.|                |::....||: ::|.|
Human   244 FIIRYRKELINNLDADSLREVQQTLEELRAV----------------AKKVHSTIQKIKKEGK-- 290

  Fly   487 RQAAAAENGDDAAEAIVVPEPEDDDDPELIDYQLKQASN----------SSPYAVFRKAGICGFA 541
                                        :.:..||...|          |:||....|......|
Human   291 ----------------------------MSECLLKAMLNCKTFEELEHVSAPYKTGSKGTKAQRA 327

  Fly   542 KHFGLTPEQYAENLRDNYQRNEITQESIGPTELA-KQYLSP---RFMTTDEVIHAAKYVVARQLA 602
            :..||  |..|..|.:.            |.||: ..|:.|   ...|..::....::::|..:|
Human   328 RQLGL--EGAARALLEK------------PGELSLLSYIRPDVKGLSTLQDIEIGVQHILADMIA 378

  Fly   603 --------------------QEPLLRKTMREV---------YFDRARINIRPTKNGMVLI---DE 635
                                |..|.:.:.::|         .:.....|||...:..:|.   .|
Human   379 KDKDTLDFIRNLCQKRHVCIQSSLAKVSSKKVNEKDVDKFLLYQHFSCNIRNIHHHQILAINRGE 443

  Fly   636 NSPVYSMKYVAKKPVSDLFGDQFIKLMMAEEEKLLEITFLEEFEGNACANGTPGDYV--EESKAL 698
            |..|.::|.    .:||...|:|.:..:....:                   |..:.  |..|.|
Human   444 NLKVLTVKV----NISDGVKDEFCRWCIQNRWR-------------------PRSFARPELMKIL 485

  Fly   699 YQLDQFAKHVQEWNKLRAECVQLALQKWVIPDLIKELRSTLHEEAQQFVLRSCTGKLYKWLKVAP 763
            |            |.|..     :.::.:.|.|.:|.|:.|..:|::..:......|.:.|..:|
Human   486 Y------------NSLND-----SFKRLIYPLLCREFRAKLTSDAEKESVMMFGRNLRQLLLTSP 533

  Fly   764 YKPQLPPDFGYEEWSTLRGIRVLGLAYDPDHSVAAFCAVTTVEGDI--SDYLRLPNILKRKNSYN 826
            ...:           ||.|:       ||.:......|:.:....|  :|.:.|
Human   534 VPGR-----------TLMGV-------DPGYKHGCKLAIISPTSQILHTDVVYL----------- 569

  Fly   827 LEEKAQKLADLRKLSDFIKMKKPHIVVI--GAESRDAQNIQADIKEILHELETSEQFPPIEVE-- 887
              ...|...:..|:...:.......|||  |...|:.:...||       |.....|.|::|.
Human   570 --HCGQGFREAEKIKTLLLNFNCSTVVIGNGTACRETEAYFAD-------LIMKNYFAPLDVVYC 625

  Fly   888 IIDNELAKIYANSKKGESDFKEYPPLLKQAASLARKMQDPLVEYSQLCDADDEILCLRYHPLQER 952
            |:....|.||:.|.:...:.....|.|:.|.|:||::||||.|..::     |...:.....|..
Human   626 IVSEAGASIYSVSPEANKEMPGLDPNLRSAVSIARRVQDPLAELVKI-----EPKHIGVGMYQHD 685

  Fly   953 VPREQLLEQLSLQFINRTSEVGLDINLMVQNSRTINLLQYICGLGPRKGQALLKLLKQSNQRLEN 1017
            |.:..|...|........|.||:|||:..:     .||::|.||...:.:.::: .::.|....|
Human   686 VSQTLLKATLDSVVEECVSFVGVDINICSE-----VLLRHIAGLNANRAKNIIE-WREKNGPFIN 744

  Fly  1018 RTQLVTVCHLGPRVFINCSGFIKID-----------TSSLGD------STEAYVEV--------- 1056
            |.||..|..|||:.|..|:|||:|:           |.:.|.      ::.|.|||
Human   745 REQLKKVKGLGPKSFQQCAGFIRINQDYIRTFCSQQTETSGQIQGVAVTSSADVEVTNEKQGKKK 809

  Fly  1057 -------------LDGSRVHPETYEWARKMAIDAMEYDDEETNPAGALEEILESPERLKDLDLDA 1108
                         ||.:.:|||:|:.|.:..          ::..|.|.|: ..||..:  .:::
Human   810 SKTAVNVLLKPNPLDQTCIHPESYDIAMRFL----------SSIGGTLYEV-GKPEMQQ--KINS 861

  Fly  1109 FAVELERQGFGSKSITLYDIRNELSCLYK--------DYRTPYTKPSAEELFDMLTKETPDSFYV 1165
            |   ||::|....:..|....:.|..:..        |:||.:.||..:.....|     :...:
Human   862 F---LEKEGMEKIAERLQTTVHTLQVIIDGLSQPESFDFRTDFDKPDFKRSIVCL-----EDLQI 918

  Fly  1166 GKCVTAMVTGFTYRRPQGDQLDSANPVRLDSNESWQCPFCHKDDFPELSEVWNHFDANACPGQPS 1230
            |..:|..|...|.                                                   .
Human   919 GTVLTGKVENATL---------------------------------------------------F 932

  Fly  1231 GVRVRLENGLPGFIHIKNLSDRQVRNPEER----VRVSQMIHVRIIKIDIDRFSVECSSRTADL 1290
            |:.|.:..|..|.|.|:|:::.::...::|    :...:.:.|:::.|||.|     |..|.||
Human   933 GIFVDIGVGKSGLIPIRNVTEAKLSKTKKRRSLGLGPGERVEVQVLNIDIPR-----SRITLDL 991

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spt6	NP_651962.2	HTH_44	308..410	CDD:464230	25/126 (20%)
		Tex	565..1278	CDD:441786	154/807 (19%)
		RuvC-like	781..935	CDD:473878	36/159 (23%)
		HHH_5	939..1042	CDD:473956	30/102 (29%)
		SH2_2	1312..1522	CDD:464227
SRBD1	NP_060549.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	23..81		15/67 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	120..165		9/45 (20%)
		Tex	210..989	CDD:441786	190/1004 (19%)