DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Spt6 and SRBD1

DIOPT Version :9

Sequence 1:NP_001284936.1 Gene:Spt6 / 44000 FlyBaseID:FBgn0028982 Length:1831 Species:Drosophila melanogaster
Sequence 2:NP_060549.4 Gene:SRBD1 / 55133 HGNCID:25521 Length:995 Species:Homo sapiens


Alignment Length:1234 Identity:238/1234 - (19%)
Similarity:416/1234 - (33%) Gaps:405/1234 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   207 QDIFGVDFDYDDFSKYEEDDYEDDSEGDEYDEDLGVGDDTR---VKKKKALKKKVVKKTIFDIYE 268
            ||:...| ::..||:......|||.|...::....|....:   .|:.|..:...|||....|.:
Human    13 QDVVLKD-EFSSFSELSSASEEDDKEDSAWEPQKKVPRSRKQPPPKESKPKRMPRVKKNAPQISD 76

  Fly   269 PSELKRGHFTDMDNEIRKTDIPERMQLREVPVTPVPEGSDELDLEAEWIYKYAFCKHTVSEQEKP 333
            .||:          .:.|.::...:.:.:   |.:.:..::||              ||...:..
Human    77 GSEV----------VVVKEELNSSVAIAD---TALEDRKNKLD--------------TVQTLKTA 114

  Fly   334 ESREKMRKPPTTVNKIKQ-----------TLEFIRNQQLEVPFIAFYRKEYVKPELNIDD----- 382
            ::::|....|.||.:.|:           .||...|.. |.|..:.......|.|.|.||     
Human   115 KTKQKCAAQPHTVRRTKKLKVEEETSKASNLEGESNSS-ETPSTSTVWGGTCKKEENDDDFTFGQ 178

  Fly   383 --LWKV---YYYDG----IWCQLNERKRKLKVLFEKMRQFQLDT-----LCA------DTDQPVP 427
              |.|:   .|..|    .....|..|.::::.::.::.....|     :||      :.|..:|
Human   179 SALKKIKTETYPQGQPVKFPANANSTKEEVEMNWDMVQVLSERTNIEPWVCANIIRLFNDDNTIP 243

  Fly   428 DDVR----LILDSDFERLADV-QSMEELKDVHMYFLLNYSHELPRMQAEQRRKAIQE-RREAKAR 486
            ..:|    ||.:.|.:.|.:| |::|||:.|                |::....||: ::|.|  
Human   244 FIIRYRKELINNLDADSLREVQQTLEELRAV----------------AKKVHSTIQKIKKEGK-- 290

  Fly   487 RQAAAAENGDDAAEAIVVPEPEDDDDPELIDYQLKQASN----------SSPYAVFRKAGICGFA 541
                                        :.:..||...|          |:||....|......|
Human   291 ----------------------------MSECLLKAMLNCKTFEELEHVSAPYKTGSKGTKAQRA 327

  Fly   542 KHFGLTPEQYAENLRDNYQRNEITQESIGPTELA-KQYLSP---RFMTTDEVIHAAKYVVARQLA 602
            :..||  |..|..|.:.            |.||: ..|:.|   ...|..::....::::|..:|
Human   328 RQLGL--EGAARALLEK------------PGELSLLSYIRPDVKGLSTLQDIEIGVQHILADMIA 378

  Fly   603 --------------------QEPLLRKTMREV---------YFDRARINIRPTKNGMVLI---DE 635
                                |..|.:.:.::|         .:.....|||...:..:|.   .|
Human   379 KDKDTLDFIRNLCQKRHVCIQSSLAKVSSKKVNEKDVDKFLLYQHFSCNIRNIHHHQILAINRGE 443

  Fly   636 NSPVYSMKYVAKKPVSDLFGDQFIKLMMAEEEKLLEITFLEEFEGNACANGTPGDYV--EESKAL 698
            |..|.::|.    .:||...|:|.:..:....:                   |..:.  |..|.|
Human   444 NLKVLTVKV----NISDGVKDEFCRWCIQNRWR-------------------PRSFARPELMKIL 485

  Fly   699 YQLDQFAKHVQEWNKLRAECVQLALQKWVIPDLIKELRSTLHEEAQQFVLRSCTGKLYKWLKVAP 763
            |            |.|..     :.::.:.|.|.:|.|:.|..:|::..:......|.:.|..:|
Human   486 Y------------NSLND-----SFKRLIYPLLCREFRAKLTSDAEKESVMMFGRNLRQLLLTSP 533

  Fly   764 YKPQLPPDFGYEEWSTLRGIRVLGLAYDPDHSVAAFCAVTTVEGDI--SDYLRLPNILKRKNSYN 826
            ...:           ||.|:       ||.:......|:.:....|  :|.:.|           
Human   534 VPGR-----------TLMGV-------DPGYKHGCKLAIISPTSQILHTDVVYL----------- 569

  Fly   827 LEEKAQKLADLRKLSDFIKMKKPHIVVI--GAESRDAQNIQADIKEILHELETSEQFPPIEVE-- 887
              ...|...:..|:...:.......|||  |...|:.:...||       |.....|.|::|.  
Human   570 --HCGQGFREAEKIKTLLLNFNCSTVVIGNGTACRETEAYFAD-------LIMKNYFAPLDVVYC 625

  Fly   888 IIDNELAKIYANSKKGESDFKEYPPLLKQAASLARKMQDPLVEYSQLCDADDEILCLRYHPLQER 952
            |:....|.||:.|.:...:.....|.|:.|.|:||::||||.|..::     |...:.....|..
Human   626 IVSEAGASIYSVSPEANKEMPGLDPNLRSAVSIARRVQDPLAELVKI-----EPKHIGVGMYQHD 685

  Fly   953 VPREQLLEQLSLQFINRTSEVGLDINLMVQNSRTINLLQYICGLGPRKGQALLKLLKQSNQRLEN 1017
            |.:..|...|........|.||:|||:..:     .||::|.||...:.:.::: .::.|....|
Human   686 VSQTLLKATLDSVVEECVSFVGVDINICSE-----VLLRHIAGLNANRAKNIIE-WREKNGPFIN 744

  Fly  1018 RTQLVTVCHLGPRVFINCSGFIKID-----------TSSLGD------STEAYVEV--------- 1056
            |.||..|..|||:.|..|:|||:|:           |.:.|.      ::.|.|||         
Human   745 REQLKKVKGLGPKSFQQCAGFIRINQDYIRTFCSQQTETSGQIQGVAVTSSADVEVTNEKQGKKK 809

  Fly  1057 -------------LDGSRVHPETYEWARKMAIDAMEYDDEETNPAGALEEILESPERLKDLDLDA 1108
                         ||.:.:|||:|:.|.:..          ::..|.|.|: ..||..:  .:::
Human   810 SKTAVNVLLKPNPLDQTCIHPESYDIAMRFL----------SSIGGTLYEV-GKPEMQQ--KINS 861

  Fly  1109 FAVELERQGFGSKSITLYDIRNELSCLYK--------DYRTPYTKPSAEELFDMLTKETPDSFYV 1165
            |   ||::|....:..|....:.|..:..        |:||.:.||..:.....|     :...:
Human   862 F---LEKEGMEKIAERLQTTVHTLQVIIDGLSQPESFDFRTDFDKPDFKRSIVCL-----EDLQI 918

  Fly  1166 GKCVTAMVTGFTYRRPQGDQLDSANPVRLDSNESWQCPFCHKDDFPELSEVWNHFDANACPGQPS 1230
            |..:|..|...|.                                                   .
Human   919 GTVLTGKVENATL---------------------------------------------------F 932

  Fly  1231 GVRVRLENGLPGFIHIKNLSDRQVRNPEER----VRVSQMIHVRIIKIDIDRFSVECSSRTADL 1290
            |:.|.:..|..|.|.|:|:::.::...::|    :...:.:.|:::.|||.|     |..|.||
Human   933 GIFVDIGVGKSGLIPIRNVTEAKLSKTKKRRSLGLGPGERVEVQVLNIDIPR-----SRITLDL 991

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Spt6NP_001284936.1 HTH_44 308..411 CDD:291314 25/127 (20%)
RuvC_resolvase 781..935 CDD:304378 36/159 (23%)
HHH_5 939..1042 CDD:304555 30/102 (29%)
DLD 1057..1159 CDD:291540 24/109 (22%)
S1 1220..1281 CDD:278972 13/64 (20%)
SH2_2 1309..1523 CDD:291307
SH2_Nterm_SPT6_like 1336..1420 CDD:198174
SH2_Cterm_SPT6_like 1429..1524 CDD:198182
SRBD1NP_060549.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 23..81 15/67 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 120..165 9/45 (20%)
Tex 208..991 CDD:225094 191/1008 (19%)
Tex_N 219..414 CDD:286460 45/254 (18%)
Tex_YqgF 538..663 CDD:293526 33/151 (22%)
HHH_3 705..767 CDD:289597 23/67 (34%)
S1_Tex 919..990 CDD:240190 19/126 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2183
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D56990at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

Return to query results.
Submit another query.