DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spt6 and eepd1

DIOPT Version :9

Sequence 1:	NP_001284936.1	Gene:	Spt6 / 44000	FlyBaseID:	FBgn0028982	Length:	1831	Species:	Drosophila melanogaster
Sequence 2:	NP_991322.1	Gene:	eepd1 / 402965	ZFINID:	ZDB-GENE-040426-1831	Length:	550	Species:	Danio rerio

Alignment Length:	400	Identity:	73/400 - (18%)
Similarity:	133/400 - (33%)	Gaps:	150/400 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   950 QERVPREQLLEQ--LSLQFINRTSEVGLDINLM-----VQNSRTINLLQYICGLGPRKGQAL-LK 1006
            |||:......|:  ::|..:||    |:..|::     :...:.:..|..:.|:|..|.:|: |:
Zfish    38 QERLNINTATEEELMTLPGVNR----GVAQNIVEYRDCIGGFKKVEDLALVSGVGATKLEAIKLE 98

  Fly  1007 LLKQSNQRLENRTQLVTVCHLGP------RVFINCSGFIKIDTS------SLGDSTEAYVEVLDG 1059
            :...|.....|.:         |      ...:.|:| :.|:|:      |:...||
Zfish    99 ICVSSKNSSSNHS---------PSSLRKEHEHLPCTG-VNINTATPPQLMSVRGITE-------- 145

  Fly  1060 SRVHPETYEWARKMAIDAMEYDDEETNPAGALEEILESPE-RLKDLDLDAFAVELERQ------- 1116
                        |:|.:.:|:.... .|..::|::::... ....||...|.|.:||.
Zfish   146 ------------KIAKNIVEFRSVH-GPFKSIEDLVKVANINSSLLDRIRFQVFVERSRTPSTNT 197

  Fly  1117 --GFGSKSITLYDIRNELSCLYKDYRTPYTKPSAEELFDMLTKETPDSFYVGKCVTAMVTGFTYR 1179
              ||...|.|.:.::::      :...|...|      .::|...|       ||
Zfish   198 NGGFTHPSPTSFSVQSD------EPDVPLGGP------PLVTSVRP-------CV---------- 233

  Fly  1180 RPQGDQLDSANPVRLDSNESWQCPFC--HKDDFPELSEVWNHFDANACPGQPSGVRVRLENGLPG 1242
            .|.....|....||:   .:|....|  .|.:.|.:.||       .|       ...|||.:.
Zfish   234 EPPAGTRDGKPVVRV---ATWNLQRCSSEKANNPGVKEV-------VC-------MTLLENDIK- 280

  Fly  1243 FIHIKNLSDRQVRNPEERVRVSQMIHVRIIKIDIDRFSVE------CSSRTADLKDVNNEWRPRR 1301
            .:.:::|:||:.                     :|:|..|      ||.|         .|:..|
Zfish   281 LLAVQDLADREA---------------------LDKFCAELNQPTLCSVR---------RWKSAR 315

  Fly  1302 DNYYDYVTEE 1311
            ..:...|:|:
Zfish   316 GLWKCAVSEK 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spt6	NP_001284936.1	HTH_44	308..411	CDD:291314
		RuvC_resolvase	781..935	CDD:304378
		HHH_5	939..1042	CDD:304555	20/105 (19%)
		DLD	1057..1159	CDD:291540	18/111 (16%)
		S1	1220..1281	CDD:278972	9/60 (15%)
		SH2_2	1309..1523	CDD:291307	1/2 (50%)
		SH2_Nterm_SPT6_like	1336..1420	CDD:198174
		SH2_Cterm_SPT6_like	1429..1524	CDD:198182
eepd1	NP_991322.1	HHH_3	38..96	CDD:289597	14/61 (23%)
		HHH_3	126..182	CDD:289597	13/77 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..216		4/27 (15%)
		MnuA_DNase1-like	246..521	CDD:197338	25/127 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2183
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900