Protein Alignment Spt6 and supt6h

DIOPT Version :10

• Sequence 1: NP_651962.2
• Gene: Spt6 / 44000
• FlyBaseID: FBgn0028982
• Length: 1831
• Species: Drosophila melanogaster
• Sequence 2: NP_660094.1
• Gene: supt6h / 337866
• ZFINID: ZDB-GENE-030131-7949
• Length: 1726
• Species: Danio rerio
• Alignment Length: 1877
• Identity: 864/1877 - (46%)
• Similarity: 1182/1877 - (62%)
• Gaps: 201/1877 - (10%)

  Fly     1 MAEFLDSEAEESEEE-EELDVNERKRLKKLKAAVSDSSEEEEDDEERLRE-ELKDLIDDNPIEED 63
            |::|::||||||||| ||.|:..:|..:.::   .|..||||:.|::... .|:.||||:.:||:
Zfish     1 MSDFIESEAEESEEEFEEKDLKPKKTQRFME---EDEEEEEENTEDQDEHGNLRGLIDDDDVEEE 62

  Fly    64 D-------GSGYDSDGVGSGKK-RKKHEDDDLDDRLEDDDYDLIEENLGVKVERR-KRFKRLRRI 119
            :       .:|.|||   ||:: |.:......||.|:|||.|||||||||||:|| |::.|::.:
Zfish    63 EEEERGEPPAGEDSD---SGEEVRHRRRKRSFDDYLDDDDLDLIEENLGVKVKRRKKKYSRVKTM 124

  Fly   120 HDNESDGEEQHVDEGLVREQIAEQLF-----DENDESIGHRSERSHREADDYDDVDTESDADDFI 179
            .|...|.:|        ::.||:::|     .|.:...|...:..|...|:.::.|.|||.||||
Zfish   125 DDEGDDDDE--------KDLIADEIFTGDGDGEGEVEDGEAVDTLHPRDDEEEEDDEESDIDDFI 181

  Fly   180 VDDNGRPIAEKKKKRRPIFTDASLQEGQDIFGVDFDYDDFSKYEEDDYEDDSEGDEYDEDLGVGD 244
            |||:|:||.:||.|:...:|||:|||.|:|||.||   ||::::.:.| |.:|.:|.|:|    |
Zfish   182 VDDDGQPITKKKGKKFSGYTDAALQEAQEIFGGDF---DFAEFDTEAY-DHAEEEEEDQD----D 238

  Fly   245 DTRVKKKKALKKKVVKKTIFDIYEPSELKRGHFTDMDNEIRKTDIPERMQLREVPVTPVPEGSDE 309
            ::..:.||..|::|.:::||:|||||||:..|.||.|||||.||:|||.|||.:||.|..:  ||
Zfish   239 ESWDRPKKQTKRRVSRRSIFEIYEPSELESSHMTDQDNEIRSTDMPERFQLRAIPVKPAED--DE 301

  Fly   310 LDLEAEWIYKYAFCKHTVSEQEKPESREK------MRKPPTTVNKIKQTLEFIRNQQLEVPFIAF 368
            |:.||||||:.||...|:|.||..:..::      .||.|:|:.|||:.|.|:|||..|||||||
Zfish   302 LEEEAEWIYRNAFSTPTISMQESTDYLDRGTTTNFSRKGPSTIAKIKEALNFMRNQHFEVPFIAF 366

  Fly   369 YRKEYVKPELNIDDLWKVYYYDGIWCQLNERKRKLKVLFEKMRQFQLDTLCADTDQPVPDDVRLI 433
            ||||||:|||||:|||||:.:|..|.||..||:.|..||::|:.:|.:.:.||.|:|:.|..|.:
Zfish   367 YRKEYVEPELNINDLWKVWQWDEKWTQLKTRKQNLTRLFQRMQSYQFEQISADPDKPLADSTRPL 431

  Fly   434 LDSDFERLADVQSMEELKDVHMYFLLNYSHELPRMQ--AEQRRKAIQERREAKARRQAAAAENGD 496
            ..:|.|||.||||::||.||:.:|||.|..::|:||  |:..:|.:::.:|       .:.|:|:
Zfish   432 DTADMERLKDVQSIDELGDVYNHFLLYYGRDIPKMQNAAKGGKKKLKKIKE-------VSEEDGE 489

  Fly   497 DAAEAIVVPEPEDDDDPELIDYQLKQASNSSPYAVFRKAGICGFAKHFGLTPEQYAENLRDNYQR 561
            :|.    |.|.|::::.:..|  |||||....|::.:.||:.|.||.|||||||:.|||||:|||
Zfish   490 EAE----VEEEEEEEEQKGPD--LKQASRRDMYSICQSAGLDGLAKKFGLTPEQFGENLRDSYQR 548

  Fly   562 NEITQESIGPTELAKQYLSPRFMTTDEVIHAAKYVVARQLAQEPLLRKTMREVYFDRARINIRPT 626
            :|..|....|.||||.|:..:|.|.:.|:..|:|:||.|:|:|||:|..:|:.:.:||:|||:||
Zfish   549 HETEQFPAEPLELAKDYVCSQFNTPEAVLEGARYMVAMQIAREPLVRHVLRQTFQERAKINIKPT 613

  Fly   627 KNGMVLIDENSPVYSMKYVAKKPVSDLFGDQFIKLMMAEEEKLLEITFLEEFEGNACANGTPGD- 690
            |.|...:||....||.||:..|||.:|.||||:|:.:||||.||.|....:..|   ..|. ||
Zfish   614 KKGKKDVDEAHFAYSFKYLKNKPVKELSGDQFLKMCLAEEEGLLAIDICIDLVG---VKGY-GDQ 674

  Fly   691 -YVEESKALYQLDQFAKHVQEWNKLRAECVQLALQKWVIPDLIKELRSTLHEEAQQFVLRSCTGK 754
             |.:|.|..|..|:|:..||||||.|...::.:||:::.|.:.|||::.|..||:..:::||..|
Zfish   675 TYFDEIKQFYYRDEFSHQVQEWNKQRTLAIERSLQQFLYPQMAKELKNKLIAEAKDNIVKSCCKK 739

  Fly   755 LYKWLKVAPYKP--QLPPDFGYEEWSTLRGIRVLGLAYDPDHSVAAFCAVTTVEGDISDYLRLPN 817
            ||.|||||||:|  |:..|....:.|..:||||||:|:........||::...||::.|:||||.
Zfish   740 LYNWLKVAPYRPDQQVEEDDDLMDESQGKGIRVLGVAFASGRDTPVFCSLINGEGEVVDFLRLPY 804

  Fly   818 ILKRKNSYNLEEKAQKLADLRKLSDFIKMKKPHIVVIGAESRDAQNIQADIKEILHELETSEQFP 882
            .|||:|::..:|:.:|..|:..|..|:..||||:|.:..|:|||..:..|||..:.|||.:...|
Zfish   805 FLKRRNAWREDEREKKQQDVENLKKFLLSKKPHVVAVSGENRDAHMVMEDIKRTISELEQNSSLP 869

  Fly   883 PIEVEIIDNELAKIYANSKKGESDFKEYPPLLKQAASLARKMQDPLVEYSQLCDADDEILCLRYH 947
            .:.||::|||||.:|.||||.|:||::|||||:||.|:|||:||||||::|:|..||:||||:.|
Zfish   870 VVGVELVDNELAVLYMNSKKSEADFRDYPPLLRQAVSVARKIQDPLVEFAQVCSTDDDILCLKLH 934

  Fly   948 PLQERVPREQLLEQLSLQFINRTSEVGLDINLMVQNSRTINLLQYICGLGPRKGQALLKLLKQSN 1012
            ||||.|.:|:||..|..:||||.:|||:|:|..:.:..|.:|:|||||||||||..|||:|||:|
Zfish   935 PLQEHVVKEELLSALYCEFINRVNEVGVDVNRAIAHPYTQSLVQYICGLGPRKGSHLLKILKQNN 999

  Fly  1013 QRLENRTQLVTVCHLGPRVFINCSGFIKIDTSSLGDSTEAYVEVLDGSRVHPETYEWARKMAIDA 1077
            .||||||||||:||:||:|||||:|||||||:||||||::|:||||||||||||||||||||:||
Zfish  1000 TRLENRTQLVTMCHMGPKVFINCAGFIKIDTASLGDSTDSYIEVLDGSRVHPETYEWARKMAVDA 1064

  Fly  1078 MEYDD--EETNPAGALEEILESPERLKDLDLDAFAVELERQGFGSKSITLYDIRNELSCLYKDYR 1140
            :|||:  |:.|||||||||||:|||||||||||||.||||||:|:|.|||||||.||||.|||.|
Zfish  1065 LEYDESAEDANPAGALEEILENPERLKDLDLDAFAEELERQGYGNKGITLYDIRAELSCRYKDLR 1129

  Fly  1141 TPYTKPSAEELFDMLTKETPDSFYVGKCVTAMVTGFTYRRPQGDQLDSANPVRLDSNESWQCPFC 1205
            .||..|:.||:|:|||||||::||:||.:|.:||...:|||||:..|.|  :|.|....||||||
Zfish  1130 APYRPPNTEEVFNMLTKETPETFYIGKLITCVVTNIAHRRPQGESYDQA--IRNDETGLWQCPFC 1192

  Fly  1206 HKDDFPELSEVWNHFDANACPGQPSGVRVRLENGLPGFIHIKNLSDRQVRNPEERVRVSQMIHVR 1270
            .:|:||||||||||||:.:||||..|||.||:|.:.|||..|.|||:.|::|||||:....:|.|
Zfish  1193 QQDNFPELSEVWNHFDSGSCPGQAIGVRTRLDNAVMGFIPTKFLSDKVVKHPEERVKPGMTVHCR 1257

  Fly  1271 IIKIDIDRFSVECSSRTADLKDVNNEWRPRRDNYYDYVTEEQDNRKVSDAKARALKRKIYARRVI 1335
            |:||||::|:|:.:.||:||.|.||||:..:|.|||:..|..|.::..:.|.:. :|..|.:|||
Zfish  1258 IMKIDIEKFNVDLTCRTSDLSDKNNEWKLPKDTYYDFDAETDDVKQEEEQKKKQ-QRTTYIKRVI 1321

  Fly  1336 AHPSFFNKSYAEVVAMLAEADQGEVALRPSSKSKDHLTATWKVADDIFQHIDVREEGKENDFSLG 1400
            |||||.|.::.:...|:...|||:|.:|||||.::|||.||||||.|:||:|||||||||.||||
Zfish  1322 AHPSFHNINFKQAEKMMESMDQGDVVIRPSSKGENHLTVTWKVADGIYQHVDVREEGKENAFSLG 1386

  Fly  1401 RSLWIGTEEFEDLDEIIARHIMPMALAARELIQYKYYKPNMVTGDENERDVMEKLLREEKANDPK 1465
            .:|||.||||||||||.||::.|||..||:|:.:||:  :...|  .:|..||:||...|...|.
Zfish  1387 HTLWINTEEFEDLDEITARYVQPMAAFARDLLGHKYF--HECNG--GDRKKMEELLVRTKKEKPT 1447

  Fly  1466 KIHYFFTASRAMPGKFLLSYLPKTKVRHEYVTVMPEGYRFRGQIFDTVNSLLRWFKEHWLDPTAT 1530
            .|.|:.:|.|.:||||||.|.|:.|.|.||||:.|:|:|:|.|||.|||.|.||||:|:.||...
Zfish  1448 FIPYYISACRDLPGKFLLGYQPRGKPRIEYVTITPDGFRYRSQIFPTVNGLFRWFKDHYQDPVPG 1512

  Fly  1531 PASASASNLTPLHLMRPPPTISSSSQTSLGPQAPYSVTGSVTGGTPRSGISSAVGGG-------- 1587
            ...||:...||..:...|..|:.:..|......|.::|..:.     :.|::..|.|
Zfish  1513 VTPASSRTRTPASVNATPANINIADLTRAVNSLPRNMTSQMF-----NAIAAVTGQGQNPNTTPA 1572

  Fly  1588 --GSSAYSITQSITGYGTSGSSAPGAGVSSSHYGSSSTPSFGAINTPYTPSGQTPFMTP---YTP 1647
              .||.|       || :.||||.|.|.|||.|        ....||..|.. ||.|||   ||.
Zfish  1573 QWASSQY-------GY-SGGSSAGGGGGSSSAY--------HVFATPQQPMA-TPLMTPSYSYTT 1620

  Fly  1648 HASQ----TPRYGHNVPSPSSQSSSSQRHHYGSSSGTGSTPRYHDMGGGGGGGVGGGGGSNAYSM 1708
            ...|    ||:|      |||...||..||..||    |||                ..|::...
Zfish  1621 PGQQQAMTTPQY------PSSTPQSSHGHHQHSS----STP----------------SSSSSRVR 1659

  Fly  1709 QPHHQQRAKENLDWQLANDAWARRRPQQHQSHQSYHAQQQHHHSQQQPHMGMSMNMGITMSLGRG 1773
            .|..:..:...:||....:.|.:.:             :.....|:.|.|
Zfish  1660 TPQPKASSHTAVDWGKMAEQWLQEK-------------EAERRKQKTPRM--------------- 1696

  Fly  1774 TGGGGGGGYGSTPVNDYSTGGGHNRGMSSKASVRSTPRTNASPHSMNLGDATPLYDE 1830
                       ||            ..|....:.|||.:.|       ||||||.||
Zfish  1697 -----------TP------------RPSPSPMIESTPMSIA-------GDATPLLDE 1723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spt6	NP_651962.2	HTH_44	308..410	CDD:464230	59/107 (55%)
		Tex	565..1278	CDD:441786	398/718 (55%)
		RuvC-like	781..935	CDD:473878	74/153 (48%)
		HHH_5	939..1042	CDD:473956	67/102 (66%)
		SH2_2	1312..1522	CDD:464227	111/209 (53%)
supt6h	NP_660094.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..196		82/208 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..248		9/33 (27%)
		HTH_44	325..410	CDD:464230	45/84 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	482..512		12/42 (29%)
		Tex	556..1276	CDD:441786	401/725 (55%)
		YqgF	766..922	CDD:258777	74/155 (48%)
		HHH_7	926..1029	CDD:291309	67/102 (66%)
		SH2_2	1313..1503	CDD:464227	108/193 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1611..1726		44/197 (22%)