DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spt6 and Supt6h

DIOPT Version :9

Sequence 1:	NP_001284936.1	Gene:	Spt6 / 44000	FlyBaseID:	FBgn0028982	Length:	1831	Species:	Drosophila melanogaster
Sequence 2:	NP_001178749.1	Gene:	Supt6h / 303281	RGDID:	1309290	Length:	1726	Species:	Rattus norvegicus

Alignment Length:	1878	Identity:	861/1878 - (45%)
Similarity:	1192/1878 - (63%)	Gaps:	203/1878 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEFLDSEAEESEEEEELDVNERKRLKKLKAAVSDSSEEEED---DEERLREELKDLIDDNPI-- 60
            |::|::|||||||||...:.....|:.|......|..||||:   |::..|..|||.|:|:..
  Rat     1 MSDFVESEAEESEEEYNHEGEVVPRVTKKFVEEEDDGEEEEEENLDDQDERGNLKDFINDDDDEE 65

  Fly    61 --EEDDG--SGYDSDGVGSGKKRKKHEDDDLDDRLEDDDYDLIEENLGVKVERRKRFKRLRRIHD 121
              |||:|  ||...|.||. ||||:   ...||||||||:|||||||||||:|.::::|::::.|
  Rat    66 EGEEDEGSDSGDSEDDVGH-KKRKR---TSFDDRLEDDDFDLIEENLGVKVKRGQKYRRVKKMSD 126

  Fly   122 NESDGEEQHVDEGLVREQIAEQLF-DENDESIGHRSERSHREADDYDDVDTESDADDFIVDDNGR 185
            ::.|.||::..|...:|.||.::| ||..|......|......|:.::.|.|||.|||||||:|:
  Rat   127 DDEDDEEEYGKEEHEKEAIAGEIFQDEEGEEGQEAVEAPMAPPDEEEEDDEESDIDDFIVDDDGQ 191

  Fly   186 PIAEKK-KKRRPIFTDASLQEGQDIFGVDFDYDDFSKYEEDDYEDDSEGD-EYDEDLGVGDDTRV 248
            |:.:.| :|:.|.:|||:|||.|:|||||||||:|.||.|  |:::.|.| ||::|...| :.||
  Rat   192 PLKKPKWRKKLPGYTDAALQEAQEIFGVDFDYDEFEKYNE--YDEELEEDYEYEDDEAEG-EIRV 253

  Fly   249 KKKKALKKKVVKKTIFDIYEPSELKRGHFTDMDNEIRKTDIPERMQLREVPVTPVPEGSDELDLE 313
            :.||..||:|.:::||::||||||:..|.||.|||||.||:|||.|||.:||....:  |||:.|
  Rat   254 RPKKTTKKRVSRRSIFEMYEPSELESSHLTDQDNEIRATDLPERFQLRSIPVKAAED--DELEEE 316

  Fly   314 AEWIYKYAFCKHTVSEQEKPESREK-------MRKPPTTVNKIKQTLEFIRNQQLEVPFIAFYRK 371
            |:|||:.||...|:|.|:..:..::       .||.|:||.|||:.|.|:|||..||||||||||
  Rat   317 ADWIYRNAFATPTISLQDSCDYLDRGQPTSSFSRKGPSTVQKIKEALGFMRNQHFEVPFIAFYRK 381

  Fly   372 EYVKPELNIDDLWKVYYYDGIWCQLNERKRKLKVLFEKMRQFQLDTLCADTDQPVPDDVRLILDS 436
            |||:|||:|:|||:|:.:|..|.||..||..|..|||||:.:|.:.:.||.|:|:.|.:|.:..:
  Rat   382 EYVEPELHINDLWRVWQWDEKWTQLRIRKENLTRLFEKMQAYQYEQISADPDKPLADGIRALDTT 446

  Fly   437 DFERLADVQSMEELKDVHMYFLLNYSHELPRMQ--AEQRRKAIQERREAKARRQAAAAENGDDAA 499
            |.|||.|||||:|||||:.:|||.|..::|:||  |:..||.::..:           |:||:..
  Rat   447 DMERLKDVQSMDELKDVYNHFLLYYGRDIPKMQNAAKASRKKLKRIK-----------EDGDEEG 500

  Fly   500 EAIVVPEPEDDDDPELIDYQLKQASNSSPYAVFRKAGICGFAKHFGLTPEQYAENLRDNYQRNEI 564
            |.      |:.:|.|....:|||||....|.:.:.||:.|.||.|||||||:.|||||:|||:|.
  Rat   501 EG------EEAEDEEQRGPELKQASRRDMYTICQSAGLDGLAKKFGLTPEQFGENLRDSYQRHET 559

  Fly   565 TQESIGPTELAKQYLSPRFMTTDEVIHAAKYVVARQLAQEPLLRKTMREVYFDRARINIRPTKNG 629
            .|....|.||||.|:..:|.|.:.|:..|:|:||.|:|:|||:|:.:|:.:.:||::||.|||.|
  Rat   560 EQFPAEPLELAKDYVCSQFPTPEAVLEGARYMVALQIAREPLVRQVLRQTFQERAKLNITPTKKG 624

  Fly   630 MVLIDENSPVYSMKYVAKKPVSDLFGDQFIKLMMAEEEKLLEITFLEEFEGNACANGTPGD--YV 692
            ...:||....||.||:..|||.:|..|||:|:.:||:|.||.|....:.:|   ..|...|  |.
  Rat   625 RKDVDEAHYAYSFKYLKNKPVKELRDDQFLKIGLAEDEGLLTIDISIDMKG---VEGYGNDQTYF 686

  Fly   693 EESKALYQLDQFAKHVQEWNKLRAECVQLALQKWVIPDLIKELRSTLHEEAQQFVLRSCTGKLYK 757
            ||.|..|..|:|:..|||||:.|...::.|||:::...:.|||::.|..||::.|:::|:.|||.
  Rat   687 EEIKQFYYRDEFSHQVQEWNRQRTMAIERALQQFLYVQMAKELKNKLLAEARESVVKACSRKLYN 751

  Fly   758 WLKVAPYKP--QLPPDFGYEEWSTLRGIRVLGLAYDP--DHSVAAFCAVTTVEGDISDYLRLPNI 818
            ||:||||:|  |:..|..:.:.:..:||||||:|:..  ||.|  |||:...||:::|:||||:.
  Rat   752 WLRVAPYRPDQQVEEDDDFMDENQGKGIRVLGIAFSSARDHPV--FCALVNGEGEVTDFLRLPHF 814

  Fly   819 LKRKNSYNLEEKAQKLADLRKLSDFIKMKKPHIVVIGAESRDAQNIQADIKEILHELETSEQFPP 883
            .||:.::..||:.:|..|:..|..|:..||||:|.:..|:||||.:..|:|.|:|||:..:|...
  Rat   815 TKRRTAWREEEREKKAQDIETLKKFLVNKKPHVVTVAGENRDAQMLIEDVKRIVHELDQGQQLSS 879

  Fly   884 IEVEIIDNELAKIYANSKKGESDFKEYPPLLKQAASLARKMQDPLVEYSQLCDADDEILCLRYHP 948
            |.||::|||||.:|.||||.|::|::|||:|:||.||||::||||:|::|:|.:|::||||::||
  Rat   880 IGVELVDNELAILYMNSKKSEAEFRDYPPVLRQAVSLARRIQDPLIEFAQVCSSDEDILCLKFHP 944

  Fly   949 LQERVPREQLLEQLSLQFINRTSEVGLDINLMVQNSRTINLLQYICGLGPRKGQALLKLLKQSNQ 1013
            |||.|.:|:||..|..:||||.:|||:|:|..:.:..:..|:||:||||||||..|||:|||:|.
  Rat   945 LQEHVVKEELLNALYCEFINRVNEVGVDVNRAIAHPYSQALIQYVCGLGPRKGTHLLKILKQNNT 1009

  Fly  1014 RLENRTQLVTVCHLGPRVFINCSGFIKIDTSSLGDSTEAYVEVLDGSRVHPETYEWARKMAIDAM 1078
            |||:||||||:||:||:||:||:||:||||:||||||::|:||||||||||||||||||||:||:
  Rat  1010 RLESRTQLVTMCHMGPKVFMNCAGFLKIDTASLGDSTDSYIEVLDGSRVHPETYEWARKMAVDAL 1074

  Fly  1079 EYDD--EETNPAGALEEILESPERLKDLDLDAFAVELERQGFGSKSITLYDIRNELSCLYKDYRT 1141
            |||:  |:.|||||||||||:|||||||||||||.||||||:|.|.|||||||.||||.|||.||
  Rat  1075 EYDESAEDANPAGALEEILENPERLKDLDLDAFAEELERQGYGDKHITLYDIRAELSCRYKDLRT 1139

  Fly  1142 PYTKPSAEELFDMLTKETPDSFYVGKCVTAMVTGFTYRRPQGDQLDSANPVRLDSNESWQCPFCH 1206
            .|..|:.||:|:|||||||::||:||.:...|||..:|||||:..|.|  :|.|....||||||.
  Rat  1140 AYRSPNTEEIFNMLTKETPETFYIGKLIICNVTGIAHRRPQGESYDQA--IRNDETGLWQCPFCQ 1202

  Fly  1207 KDDFPELSEVWNHFDANACPGQPSGVRVRLENGLPGFIHIKNLSDRQVRNPEERVRVSQMIHVRI 1271
            :|:||||||||||||:.:||||..||:.||:||:.|||..|.|||:.|:.|||||:|...:|.||
  Rat  1203 QDNFPELSEVWNHFDSGSCPGQAIGVKTRLDNGVTGFIPTKFLSDKVVKRPEERVKVGMTVHCRI 1267

  Fly  1272 IKIDIDRFSVECSSRTADLKDVNNEWRPRRDNYYDYVTEEQDNRKVSDAKARALKRKIYARRVIA 1336
            :||||::||.:.:.||:||.|.||||:..:|.|||:..|..|:::..|.| |..:|..|.:||||
  Rat  1268 MKIDIEKFSADLTCRTSDLMDRNNEWKLPKDTYYDFDAEAADHKQEEDMK-RKQQRTTYIKRVIA 1331

  Fly  1337 HPSFFNKSYAEVVAMLAEADQGEVALRPSSKSKDHLTATWKVADDIFQHIDVREEGKENDFSLGR 1401
            ||||.|.::.:...|:...|||:|.:|||||.::|||.||||:|.|:||:|||||||||.||||.
  Rat  1332 HPSFHNINFKQAEKMMETMDQGDVIIRPSSKGENHLTVTWKVSDGIYQHVDVREEGKENAFSLGA 1396

  Fly  1402 SLWIGTEEFEDLDEIIARHIMPMALAARELIQYKYYKPNMVTGDENERDVMEKLLREEKANDPKK 1466
            :|||.:|||||||||:||::.|||..||:|:.:|||: :...||   |..:|:||.:.|...|..
  Rat  1397 TLWINSEEFEDLDEIVARYVQPMASFARDLLNHKYYQ-DCSGGD---RKKLEELLIKTKKEKPTF 1457

  Fly  1467 IHYFFTASRAMPGKFLLSYLPKTKVRHEYVTVMPEGYRFRGQIFDTVNSLLRWFKEHWLDPT--A 1529
            |.||..|.:.:||||||.|.|:.|.|.|||||.|||:|:|||||.|||.|.||||:|:.||.  .
  Rat  1458 IPYFICACKELPGKFLLGYQPRGKPRIEYVTVTPEGFRYRGQIFPTVNGLFRWFKDHYQDPVPGI 1522

  Fly  1530 TPASASASNLTPLHLMRPPPTISSSSQTSLGPQAPYSVTGSVTGGTPRSGISSAVGGGGSSAYSI 1594
            ||:|:|.:. ||..:...|..|:.:..|......|.::|                    |..:|.
  Rat  1523 TPSSSSRTR-TPASINATPANINLADLTRAVNALPQNMT--------------------SQMFSA 1566

  Fly  1595 TQSITGYGTSGSSAPGAGVSSSH-YGSS--STPSFGAINTPYTPSGQTPFMTPYTPHASQTPRYG 1656
            ..::||.|.:.::.|....||.: ||.|  .:.::....||    .|.|..||.     .||.|.
  Rat  1567 IAAVTGQGQNPNATPAQWASSQYGYGGSGGGSSAYHVFPTP----AQQPVATPL-----MTPSYS 1622

  Fly  1657 HNVPSPSSQSSSSQRHHYGSSSGTGSTPRYHDMGGGGGGGVGGGGGSNAYSMQP-----HHQQRA 1716
            :..|   ||..::.::|...:|   :||:                 |.....||     ..||:.
  Rat  1623 YTTP---SQPITTPQYHQLQAS---TTPQ-----------------STQAQPQPSSSSRQRQQQP 1664

  Fly  1717 KEN----LDWQLANDAWARRRPQQHQSHQSYHAQQQHHHSQQQPHMGMSMNMGITMSLGRGTGGG 1777
            |.|    :||....:.|.:.:..:.:
  Rat  1665 KSNSHAAIDWGKMAEQWLQEKEAERR--------------------------------------- 1690

  Fly  1778 GGGGYGSTPVNDYSTGGGHNRGMSSKASVRSTPRTNASP----HSMNL-GDATPLYDE 1830
                                     |...|.|||.:.||    ..|:: ||||||.||
  Rat  1691 -------------------------KQKQRLTPRPSPSPMIESTPMSIAGDATPLLDE 1723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spt6	NP_001284936.1	HTH_44	308..411	CDD:291314	58/109 (53%)
		RuvC_resolvase	781..935	CDD:304378	76/155 (49%)
		HHH_5	939..1042	CDD:304555	61/102 (60%)
		DLD	1057..1159	CDD:291540	81/103 (79%)
		S1	1220..1281	CDD:278972	34/60 (57%)
		SH2_2	1309..1523	CDD:291307	117/213 (55%)
		SH2_Nterm_SPT6_like	1336..1420	CDD:198174	53/83 (64%)
		SH2_Cterm_SPT6_like	1429..1524	CDD:198182	49/94 (52%)
Supt6h	NP_001178749.1	HTH_44	<348..422	CDD:291314	46/73 (63%)
		Tex	372..1353	CDD:225094	520/1005 (52%)
		Tex_N	<565..623	CDD:286460	26/57 (46%)
		YqgF	775..931	CDD:258777	76/157 (48%)
		HHH_7	935..1038	CDD:291309	61/102 (60%)
		DLD	1053..1157	CDD:291540	81/103 (79%)
		S1	<1227..1282	CDD:197648	29/54 (54%)
		SH2_2	1304..1514	CDD:291307	117/214 (55%)
		SH2_Nterm_SPT6_like	1331..1415	CDD:198174	53/83 (64%)
		SH2_Cterm_SPT6_like	1424..1515	CDD:198182	49/94 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351516
Domainoid	1	1.000	282	1.000	Domainoid score	I1582
eggNOG	1	0.900	-	-		E1_COG2183
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40661
Inparanoid	1	1.050	1572	1.000	Inparanoid score	I81
OMA	1	1.010	-	-		QHG55107
OrthoDB	1	1.010	-	-		D51869at33208
OrthoFinder	1	1.000	-	-		FOG0004092
OrthoInspector	1	1.000	-	-		oto97065
orthoMCL	1	0.900	-	-		OOG6_102925
Panther	1	1.100	-	-	LDO	PTHR10145
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2838
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770