Protein Alignment Spt6 and Srbd1

DIOPT Version :10

• Sequence 1: NP_651962.2
• Gene: Spt6 / 44000
• FlyBaseID: FBgn0028982
• Length: 1831
• Species: Drosophila melanogaster
• Sequence 2: XP_006239770.1
• Gene: Srbd1 / 301665
• RGDID: 1562788
• Length: 983
• Species: Rattus norvegicus
• Alignment Length: 1327
• Identity: 248/1327 - (18%)
• Similarity: 438/1327 - (33%)
• Gaps: 456/1327 - (34%)

  Fly    47 LREELKDLIDDNPIEEDDGSGYDSDGVGSGKKRKKHEDDDLDDRLEDDDYDLIEENL--GVKVER 109
            ||:..| :..:|....|:.|.:.....||       |:|:.:|.:.:....::....  ..|..:
  Rat     7 LRKRTK-IQTENAEPRDECSSFSELSSGS-------EEDNKEDSIWEPQKKVLRNRRRPASKGSK 63

  Fly   110 RKRFKRLRR----IHDNESD---GEEQHVDEGLVREQIAEQLFDENDESIGHRSERSHREADDYD 167
            ||:..|:::    :||...|   .||.:....:|...:.|:            :::.|
  Rat    64 RKQGPRVKKSAQQVHDISKDVAVKEELNSPVAIVNANLEEE------------NQKLH------- 109

  Fly   168 DVDTESDADDFIVDDNGRPIAEKKKKRRPIFTDASLQEGQDIFGVDFDYDDFSKYE--EDDYEDD 230
                         ..|....|.||:|.........|:       ||.:.:..|.:|  |.:.|..
  Rat   110 -------------TTNTLKTAAKKQKNAGHGAKKRLK-------VDEETNQASPFEGGESNVEAP 154

  Fly   231 SEGDEYDEDLGVGDDTRVKKKKALKKKVVKKTIFD--IYEPSELKRGHFTDMDNEIRKTDIPERM 293
            |..::.|                    :.||...|  .:|.|.|||         |:....|:..
  Rat   155 STSEDRD--------------------MCKKESEDSFTFEQSPLKR---------IKTESCPQGR 190

  Fly   294 QLREVPVTPVPEGSD-ELDLEAEWIYKYAFCKHTVSEQEKPESREKMRKPPTTVNKIKQTLEFIR 357
            ..|      ||..|| :.::|..|.......:.|..|            |....|.|:     :.
  Rat   191 PAR------VPGASDIKEEVEMNWDIVQVLSERTNIE------------PWICANIIR-----LF 232

  Fly   358 NQQLEVPFIAFYRKEYVKPELNIDDLWKVYYYDGIWCQLNERKRKLKVLFEKMRQFQLDTLCADT 422
            |....:|||..||||.:..
  Rat   233 NDDNTIPFIVRYRKELINN---------------------------------------------- 251

  Fly   423 DQPVPDDVRLILDSDFERLADV-QSMEELKDVHMYFLLNYSHELPRMQAEQRRKAIQE-RREAKA 485
                       ||:||  |.:| |:::||:||                |::....||: ::|.|.
  Rat   252 -----------LDADF--LREVRQTLDELRDV----------------AKKVHSRIQKIKKEGKM 287

  Fly   486 RR---QAAAAENGDDAAEAIVVPEPEDDDDPELIDYQLKQASNSSPYAVFRKAGICGFAKHFGLT 547
            ..   ||.......:..|.:                       |:||.:..|......||..||
  Rat   288 SECLLQALLNCKTFEELEHV-----------------------SAPYKMGSKGTKAQRAKQLGL- 328

  Fly   548 PEQYAENLRDNYQRNEITQESIGPTEL-AKQYLSPRFMTTDE---VIHAAKYVVARQLAQEPLLR 608
             |..|..|.:|            |.:| ...|:.|......|   :....::::|..:|::....
  Rat   329 -EGAAWTLLEN------------PGQLNLPSYIRPDVKGLSELKDIETGVQHILADMIAKDKDTL 380

  Fly   609 KTMREVYFDRARINIRPTKNGMVLIDENSPVYSMKYVAKKPVS-------------DLFGDQFIK 660
            ..:|::           .|:..:.|..:....|.|.|.:|.|.             ::...|.:.
  Rat   381 DFIRDL-----------CKHRYICIQSSLAKVSSKKVNEKEVDKFQLYQNFSCNIRNIHHHQILA 434

  Fly   661 LMMAEEEKLLEITFLEEFEGNACANGTPGDYVE---ESKALYQLDQFAKHVQEWNKLRAECVQLA 722
            :...|..|:|.:..       ..::|...::..   :::  ::...||:  .|..|:....:..:
  Rat   435 INRGENLKILTVKV-------NISDGVKNEFCRWCIQNR--WRPRGFAR--PELMKILHNSLDDS 488

  Fly   723 LQKWVIPDLIKELRSTLHEEAQQFVLRSCTGKLYKWLKVAPYKPQLPPDFGYEEWSTLRGIRVLG 787
            .::.::|.|.:|||:.|..:|::..:......|.:.|..:|...:           ||.|:
  Rat   489 FKRLIVPLLCRELRAKLTSDAEKQSVMMFGQNLRQLLLTSPVPGR-----------TLMGV---- 538

  Fly   788 LAYDPDHSVAAFCAVTTVEGDI--SDYLRLPNILKRKNSYNLEEKAQKLADLRKLSDFIKMKKPH 850
               ||.:......|:.:....|  :|.:.|             ...|...:..|:...:.....:
  Rat   539 ---DPGYKHGCKLAIISPTSQILHTDVVYL-------------HCGQGFREAEKIKRLLLNFNCN 587

  Fly   851 IVVI--GAESRDAQNIQADIKEILHELETSEQFPPIEVE--IIDNELAKIYANSKKGESDFKEYP 911
            .|||  |...|:.:...||       |.....|.|::|.  |:....|.||:.|.:...:.....
  Rat   588 TVVIGNGTACRETEAYFAD-------LIMKNYFAPLDVVYCIVSEAGASIYSVSPEANKEMPGLD 645

  Fly   912 PLLKQAASLARKMQDPLVEYSQLCDADDEILCLRYHP-------LQERVPREQLLEQLSLQFINR 969
            |.|:.|.|:||::||||.|            .:::.|       .|..|.:..|...|.......
  Rat   646 PNLRSAVSIARRVQDPLAE------------LVKFDPKHIGVGMYQHDVSQTLLKATLDSVVEEC 698

  Fly   970 TSEVGLDINLMVQNSRTINLLQYICGLGPRKGQALLKLLKQSNQRLENRTQLVTVCHLGPRVFIN 1034
            .|.||:|||:..:     .||::|.||...:.:.::: .::.|....||.||..|..|||:.|..
  Rat   699 VSFVGVDINICSE-----VLLRHIAGLNANRAKNIIE-WREKNGPFINREQLKKVKGLGPKSFQQ 757

  Fly  1035 CSGFIKID------------TSSLGDSTEAYV-------------------EVLDGSRVHPETYE 1068
            |:||::::            |.|.|.|.||.:                   ..||.:.:|||:|:
  Rat   758 CAGFVRVNQDYIRTFCSGQHTDSSGQSQEAAMVTKEKPGKKKNKADVALTPNPLDETCIHPESYD 822

  Fly  1069 WARKMA--IDAMEYD------DEETNPAGALEEILESPERLKDLDLDAFAVELERQGFGSKSITL 1125
            .|.:..  |....|:      .::.|.:...|.|.::.|||:   ..|..:::...|.....  .
  Rat   823 IAVRFLSFIGGTLYEIGKPEMQQKINSSLGKEGIEKTAERLQ---TTAHTLQVIIDGLSQPK--T 882

  Fly  1126 YDIRNELSCLYKDYRTPYTKPSAEELFDMLTKETPDSFYVGKCVTAMVTGFTYRRPQGDQLDSAN 1190
            :|||.       |:..|..|.|...|.|:         .||..:|..|...|.
  Rat   883 FDIRT-------DFDKPDFKRSIVCLADL---------QVGTILTGKVENATL------------ 919

  Fly  1191 PVRLDSNESWQCPFCHKDDFPELSEVWNHFDANACPGQPSGVRVRLENGLPGFIHIKNLSDRQVR 1255
                                                   .||.|.:..|..|.|.|:.:::.::.
  Rat   920 ---------------------------------------FGVFVDIGVGKAGLIPIRFITEAKLS 945

  Fly  1256 NPEER----VRVSQMIHVRIIKIDIDR 1278
            ..::|    :...:.:.|:::.:||.|
  Rat   946 KTKKRRSLGLGPGEKVEVKVLSVDIPR 972

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spt6	NP_651962.2	HTH_44	308..410	CDD:464230	16/102 (16%)
		Tex	565..1278	CDD:441786	149/788 (19%)
		RuvC-like	781..935	CDD:473878	36/159 (23%)
		HHH_5	939..1042	CDD:473956	29/109 (27%)
		SH2_2	1312..1522	CDD:464227
Srbd1	XP_006239770.1	Tex	206..977	CDD:441786	195/1046 (19%)