DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spt6 and ZK973.1

DIOPT Version :9

Sequence 1:	NP_001284936.1	Gene:	Spt6 / 44000	FlyBaseID:	FBgn0028982	Length:	1831	Species:	Drosophila melanogaster
Sequence 2:	NP_491362.1	Gene:	ZK973.1 / 172040	WormBaseID:	WBGene00022830	Length:	745	Species:	Caenorhabditis elegans

Alignment Length:	664	Identity:	136/664 - (20%)
Similarity:	256/664 - (38%)	Gaps:	156/664 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   452 DVHMYFLLNYSHELPRMQAEQRRKAIQERREAK--------ARRQAAAAENGDDAAEAIVVPEP- 507
            |||.|           :..|:.|||::...:||        |.....|...|  |.|.|:|.|.
Worm    55 DVHGY-----------LAPEKIRKAMEAYVDAKNLNNKVSSAISTVTAKVAG--AQEKIIVTERF 106

  Fly   508 ---EDDDDPELIDYQLKQASNSSPYAVFRKAGICGFAKHFGLTPEQYAENLRDNYQRNEITQESI 569
               |:.|  |:.|.       |..|:...:......|:..||.|.  |:::.|.   |.:..:|:
Worm   107 KRCEEFD--EVTDI-------SKEYSTGTRKTKANIARALGLEPP--AQSILDG---NFVDFKSL 157

  Fly   570 GPTELAKQYLSPRFMTTDEVIHAAKYVVARQLAQEPLLRKTMR--EVYFDRARINIRPTKNGMVL 632
                     ||....|..:|....|..:|..:.::..:||...  ::.....|::.:.::..
Worm   158 ---------LSNGLKTVKDVEEHLKICLADLINRDEEVRKVSANIDILKKECRVSAKLSREA--- 210

  Fly   633 IDENSPVYSMKYVAKKPVSDLFGDQFIKLMMAEEEKLLEITFLEEFEGNACANGTPGDYVEESKA 697
             ::|......:.:.:| ..:..|:::    .||:        :.:...:|...|     .:|...
Worm   211 -EKNRKDLEKRGIIEK-YKNFIGEKW----NAED--------IRDHTVSALNKG-----FDEGII 256

  Fly   698 LYQLD-QF--AKHVQEWNK---------LRAECVQLALQKWVIPDLIKELRSTLHEEA--QQFVL 748
            .:::: :|  ||::..:::         ...|.:..:::.:.||.:.:::.:.|.::|  :..||
Worm   257 TWKIECEFNDAKYIHPFSRKSVYFGMKNFYQEALAYSIKNYFIPRIERKMANHLKDKAKDRSIVL 321

  Fly   749 RSCTGKLYKWLKVAPYKPQLPPDFG--YEEWSTLRGIR-VLGLAYDPDHS--VAAFCAVTTVEGD 808
                                   ||  .::..:..||| ...:|.||..|  ..||...|....|
Worm   322 -----------------------FGENVDQLLSQEGIRDKFVIALDPGRSKIKTAFLKPTGEVVD 363

  Fly   809 ISDYLRLPNILKRKNSYNLEEKAQKLADLRKLSDFIKMKKPHIVVIGAESRDAQNIQADIKEILH 873
            :|.:          :.|........:..|:|.|.  :.::..||.......:..|.|..:.::::
Worm   364 MSSF----------SIYGTRFDGGGVDLLKKWSQ--QTERKDIVFAIGNGTNTYNTQIAVSDMIN 416

  Fly   874 ELETSEQFP-PIEVE--IIDNELAKIYANSKKGESDFKEYPPLLK-QAASLARKMQDPLVEYSQL 934
                |..|| .|.|.  |:....|..|:.:.....:|.|...:.: .|.|:.|::.||:.||.::
Worm   417 ----SNVFPKEINVSYCIVPEHGASKYSCTPSAIEEFGENAEITEISAVSIGRRLIDPMSEYVKI 477

  Fly   935 CDADDEILCLRYHPLQERVPREQLLEQLSLQFINRTSEVGLDINLMVQNSRTINLLQYICGLGPR 999
                 |...|.....|..|..::|.|.|.....:|.|..|:|:     |:.:.||||.|.||..:
Worm   478 -----EPQHLGKGQYQLSVDPKKLNESLLNVVRDRVSFNGVDL-----NTASKNLLQRINGLNEK 532

  Fly  1000 KGQALLKLLKQSNQRLENRTQLVTVCHLGPRVFINCSGFIKI---DTSSLG--------DSTEAY 1053
            ..:.::: .::.|.|..:|.:|..|..:|...|..|:||:.:   |.:..|        .||...
Worm   533 TAKEIVQ-YREQNGRFRSRAELKEVKGIGALTFQQCAGFLTVSRPDDAEDGPPKKKFKKSSTSKE 596

  Fly  1054 VEVLDGSRVHPETY 1067
            ....|.:.|||:.|
Worm   597 WNPFDETIVHPDDY 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spt6	NP_001284936.1	HTH_44	308..411	CDD:291314
		RuvC_resolvase	781..935	CDD:304378	37/160 (23%)
		HHH_5	939..1042	CDD:304555	29/105 (28%)
		DLD	1057..1159	CDD:291540	5/11 (45%)
		S1	1220..1281	CDD:278972
		SH2_2	1309..1523	CDD:291307
		SH2_Nterm_SPT6_like	1336..1420	CDD:198174
		SH2_Cterm_SPT6_like	1429..1524	CDD:198182
ZK973.1	NP_491362.1	Tex	27..742	CDD:225094	136/664 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2183
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D56990at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820