DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trbl and mark3b

DIOPT Version :9

Sequence 1:	NP_524672.1	Gene:	trbl / 43999	FlyBaseID:	FBgn0028978	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	XP_009293196.1	Gene:	mark3b / 767634	ZFINID:	ZDB-GENE-060929-80	Length:	834	Species:	Danio rerio

Alignment Length:	423	Identity:	110/423 - (26%)
Similarity:	172/423 - (40%)	Gaps:	81/423 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 QRYLISAQPSHIS--------------------AAVAAKTP--ASYRHLVDLTASNLRCV----D 144
            :|:.|:...||..                    |:.|.:.|  .:||.|..:...|...|    .
Zfish    31 KRHRITIHTSHTDGRNEVASRPGRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARH 95

  Fly   145 IFTGEQFLCRIVNEPLHKVQRAYFQLQQHDEELRRSTIYGHPLIRPVHDIIPLTKDRTYILIAPV 209
            |.||.:...:|::    |.|.....||:...|:|...|..||.|..:.::|  ..|:|..|:...
Zfish    96 ILTGREVAIKIID----KTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVI--ETDKTLYLVMEY 154

  Fly   210 PQERDSTGGVTGVYENLHTYIRHAKRLCETEARAIFHQICQTVQVCHRNGIILRDLKLKRFYFID 274
                 ::||  .|::.|   :.|. |:.|.||||.|.||...||.||:..|:.||||.:......
Zfish   155 -----ASGG--EVFDYL---VAHG-RMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDA 208

  Fly   275 EARTKLQYESLEGSMILDGEDDTLSDKIGCPLYTAPELLCPQQTYKGKPADMWSLGVILYTMLVG 339
            :...|:..........:..:.||.   .|.|.|.||||. ..:.|.|...|:|||||||||::.|
Zfish   209 DMNIKIADFGFSNEFTIGNKLDTF---CGSPPYAAPELF-QGKKYDGPEVDVWSLGVILYTLVSG 269

  Fly   340 QYPFYEKANCNLITVIRHGNVQIPLTLSKSVRWLLLSLLRKDYTERMTASHIFLTPWL------R 398
            ..||..:....|...:..|..:||..:|.....||...|..:..:|.|...|....|:      .
Zfish   270 SLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPVKRGTLEQIMKDRWINAGCEEE 334

  Fly   399 EQRPFHMYLPVDVEVAEDWSDAEEDEGTAADAM-------DDDEEGLCPLGDKHEYEDIGVEPLD 456
            |.:||       ||...|.||.:.     .|.|       ::..|.|    .:.:|::|....|.
Zfish   335 ELKPF-------VEPELDISDQKR-----IDIMVGMGYSREEIHESL----TRMKYDEITATYLL 383

  Fly   457 YTRSTLQM----AQNANGLS-TEPEPDTDVDMG 484
            ..|.:.::    :.:::.|| .:..|:::.:.|
Zfish   384 LGRKSTELEVSDSSSSSNLSLAKARPNSEHNNG 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trbl	NP_524672.1	PKc_like	131..397	CDD:328722	80/269 (30%)
mark3b	XP_009293196.1	STKc_MARK	75..327	CDD:270974	82/272 (30%)
		S_TKc	76..327	CDD:214567	82/271 (30%)
		UBA_MARK3_4	345..387	CDD:270590	10/50 (20%)
		MARK1-3_C	735..832	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910