Protein Alignment trbl and nipi-3

DIOPT Version :10

• Sequence 1: NP_524672.1
• Gene: trbl / 43999
• FlyBaseID: FBgn0028978
• Length: 484
• Species: Drosophila melanogaster
• Sequence 2: NP_510573.3
• Gene: nipi-3 / 181650
• WormBaseID: WBGene00010700
• Length: 655
• Species: Caenorhabditis elegans
• Alignment Length: 510
• Identity: 123/510 - (24%)
• Similarity: 192/510 - (37%)
• Gaps: 112/510 - (21%)

  Fly    42 SSSGMSSSQEDTVLGLFTPK--KEFPNAKMLQTIREKLMTPGGACDLLALGIAAEPTDQQ-PVKL 103
            ||.|.:.:.|...||...|.  |.. |...:|..|.. |.|  |.||...|  ..|.:|: |..|
 Worm    97 SSIGPAKTLELRPLGRLPPHIIKAL-NDHYVQLTRGS-MVP--AADLYNNG--DHPAEQRIPTML 155

  Fly   104 IQQRYL----------ISAQPSHISAAVAAKTPASYRHLVDLTASNLRCVDIF------------ 146
            .:..||          .|.|.|..|::.....|.|.:|||     |...:.||
 Worm   156 NENEYLRLIQELEEEEKSKQFSATSSSAPHVNPYSAQHLV-----NGEIIGIFVIYGTGLVTRAV 215

  Fly   147 ---TGEQFLCRIVNE-PLHKVQRAYFQLQ-------QHDEELRRSTIYGHPLIRPVHDIIPLTKD 200
               |.|.|...::.| ...||.....:||       ...:|:|.|.:    .|....:||. :.|
 Worm   216 CSQTREMFTAHVLPEWKASKVIDVIRRLQIPTDISSMTADEIRLSEL----CISKRMEIIK-SND 275

  Fly   201 RTYILIAPVPQERDSTGGVTGVYENLHTY-IRHAKRLCETEARAIFHQICQTVQVCHRNGIILRD 264
            | |||:.|...            ..:|:| ......:.|.:..:|:.::.:.|:.||...:||::
 Worm   276 R-YILMNPCES------------ATIHSYATERLDEITENDVMSIYQKVVEIVRFCHSRKVILQN 327

  Fly   265 LKLKRFYFIDEARTK-------LQYESLEGSMILDGEDDTLSDKIGCPLYTAPELLCPQ-QTYKG 321
            .|.:.||...:|..|       ||..|.|.    |..:...:.:..|..:.|||:|..: :|:..
 Worm   328 FKPRSFYLKKDAHNKWVVRPCFLQDMSCEE----DQSEAQFTRRSVCVPFMAPEMLTAESRTHHS 388

  Fly   322 KPADMWSLGVILYTMLVGQYPFYEKANCNLITVIRHGNVQIPLT-LSKSVRWLLLSLLRK----- 380
            ...::|.|||:||.:|.|:|||:|.:...|...|:....:.|.. :|...|.::..||:|
 Worm   389 YSTELWGLGVLLYILLTGKYPFHENSMPLLFRTIKFKQHRWPFNFISSKSRNIVNMLLKKAPATR 453

  Fly   381 ------------DYTERMTASHIFL--TPWLREQRPFHMY--------LPVDV-EVAEDWSDAEE 422
                        |:.|....|:|.|  ...:.:...|.||        ||.:| .:.|:......
 Worm   454 MNLEDLWNQVNGDFPEIRCRSNIILKKQDMIVKMDLFEMYYNTYKDRLLPKNVLPMYEEMKACRN 518

  Fly   423 DEGTAADAMDDDEEGLCPLGDKHEYEDIGVEPLDYTRSTLQM-AQNANGLSTEPE 476
            |.....:....|...:    .:.....|..:|.:|....:|: .|..|.|..|.|
 Worm   519 DSTILTEMAKRDFRSI----QEQMKRRIETKPTEYQTLVMQVRLQQINQLFFEKE 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trbl	NP_524672.1	Protein Kinases, catalytic domain	131..397	CDD:473864	76/317 (24%)
nipi-3	NP_510573.3	Protein Kinases, catalytic domain	208..459	CDD:473864	65/272 (24%)