DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jbug and GEX2

DIOPT Version :9

Sequence 1:	NP_001261140.1	Gene:	jbug / 43997	FlyBaseID:	FBgn0028371	Length:	2990	Species:	Drosophila melanogaster
Sequence 2:	NP_001330856.1	Gene:	GEX2 / 834974	AraportID:	AT5G49150	Length:	1087	Species:	Arabidopsis thaliana

Alignment Length:	1316	Identity:	240/1316 - (18%)
Similarity:	383/1316 - (29%)	Gaps:	535/1316 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly  1064 SHSNNTYTDKSGGYTKTVKESSEHVVTESNGHGPSPGYGYSSLSRFRPIDGNAT-GARAIRVQDI 1127
            |.||:....|||    .:.|.|..|:...:.|                  |||: |.||.:....
plant    38 SWSNDKNKFKSG----EISEISIKVLGNFDNH------------------GNASLGQRAFKPTVT 80

  Fly  1128 PNGSIGRPVEFEIDGSRAGSGNLEILVNGGRVTSSVRSLGG--QRFIASFTPHEHGTHTVQITFN 1190
            .||.:|                     |...::.....||.  ..:...|||...|...:.|...
plant    81 VNGKLG---------------------NSTYISGVSLDLGEDISNWKIYFTPIMVGIFNIVIDEE 124

  Fly  1191 GETVPGSPWHAE-----------IMSSPGLTALGESTRLVPANTPAVFEILPP---------PGQ 1235
            ...|..|..|.|           ::|..||..:.|      |...|...|||.         .|:
plant   125 NFKVLDSSLHFEVEAGLMYPSVSVVSWMGLANVFE------AGMNASILILPKDAFGNNISFSGK 183

  Fly  1236 SLSKGECVATVLTPSKS---KLNARVTHEAANGAARIEFVPTEVGTHVIDASINGTKIAGGPLIA 1297
            .:...|...::::.:.|   .||:.......:|...|:||....|..::........:.||||..
plant   184 KMEFQEFSLSLISENGSFAGVLNSTHIRWIVSGYISIDFVLVTSGKFLLLVEKESQTLNGGPLPL 248

  Fly  1298 KVYDSSL-------IQVTEVN------------------GGVVGQACQFRVDASAAGEGQLEISI 1337
            :|....|       |..:|::                  |.:|....:|..|......| |.|.:
plant   249 EVNSGPLDVSNCVSIWKSELSTWQIFSKMEILLHQKDRFGNIVSGFYEFDADVVEVETG-LSIPV 312

  Fly  1338 NEGEVPNHVQVVGGGRCLVSFTPEQAKSHLI---DIKFNGETVRGCPFVCAV----ADTSRVLLN 1395
            .:.:    .:.|..|..|:|||..:..:.|:   |:|.| :::...|:|..|    .|.||.::|
plant   313 ADFQ----FEYVEPGIQLMSFTLSEPGNFLLTLSDMKHN-KSISSMPYVYTVYIGYCDGSRSIVN 372

  Fly  1396 LSNLELIPVNRPSSFHITVSGGGAAELAVSVRGPQGELPVRVTGDIHAGFTAEFTPTTVGGHSIN 1460
            .|.:.                                                   .::.|.|:
plant   373 GSGIN---------------------------------------------------ASIAGESL- 385

  Fly  1461 VEYNGFAVQGTPFLAKSYDASKVVVGSVSRGTMGRPVQFTVDAGDAGEGNLEITISAKGQNIPTQ 1525
                ||:|    :|..:|                                        |...|.|
plant   386 ----GFSV----YLKDAY----------------------------------------GYPSPVQ 402

  Fly  1526 VHPQGSARFSVSFVPTESCEHTINVSFNKMPVPGCPITVSISGGVAGPQVSLGGPGPVHQTNSFV 1590
            |.     |..|..|                    ..|..||......|:.:|.|.|..||..:.:
plant   403 VD-----RLQVRIV--------------------LEIDSSIILPTIQPREALNGTGSSHQAATPL 442

  Fly  1591 INHNGGRLEDIEVNVEGPAGQSVPAQVHQSADGVFKAEFVPRVVGEHRV-----NVTVNGLPTAG 1650
            ...:|||           |..::..|.     .:|...:.|:..|.:|:     |:.:||    |
plant   443 YEKHGGR-----------ASGNLVTQA-----SIFDVTYTPKRTGIYRIFISSGNIVLNG----G 487

  Fly  1651 SPYAAKVYDVSAIKVKNVSSGTVGKAVTFLVETSQAGPGNLEVTVNGGRVPTSAQAQGQHTYAIS 1715
            .|:           :|.|.:|.|..|.             ..||...|:|
plant   488 QPF-----------IKEVYAGEVNVAA-------------CSVTQFNGKV--------------- 513

  Fly  1716 FTPREAESHTVELRFNS--QDVPGSPFTCRVAAAARIQSPETMDKVSVGRLFEFVVESDTKPTVE 1778
              |:|.::..|.|..:.  ..||..|        :|::...|....|....:|||..:|
plant   514 --PKEIKNEIVVLLLDGFYNPVPSQP--------SRLKFEITSANTSSFTTWEFVDNND------ 562

  Fly  1779 VLGPARRSVPVKIDALGSSTLGYNVKFEPMEVGDHSVEVRLPGGGHVEGSPFLLKAYS------- 1836
                            |:    |...:..||||.:.:.:.. ...|::..||.:..||
plant   563 ----------------GT----YTGSYLAMEVGTYRMCISF-DNKHIQPCPFDVNVYSNGYFPRA 606

  Fly  1837 -AEKVIVTDIRAGVVNKSVSF---------GINASQAG------------------------AGN 1867
             .:.|.|.:      ::|:||         |.|||..|                        :||
plant   607 YDDPVNVWE------DESISFNPLENDYFAGDNASMLGFSQPGHGSLLRDGNLLRYTPMKNFSGN 665

  Fly  1868 ---LEIIVAVNGKNV------------PNFVQSEGNARFKVNFKPTEAATHSLSVRFNGHPVPGS 1917
               |..|..:||...            |.||...|.         .:|....:|.|:.|
plant   666 DSFLYTIADINGNLAAATVYIFVLTAPPQFVSFSGG---------LQATEDLISPRYGG------ 715

  Fly  1918 PFSCHIAAAAASPSMGLPRAMAMGECLKQAAVKMDNTFELEGFDGVEPQIFVTSPSGDNEHCQLS 1982
             ||            ||  .::..:.|:..:|.:.   .|.|...:.|.:.
plant   716 -FS------------GL--EISYSDLLENISVMVQ---ALSGSVILSPMLM-------------- 748

  Fly  1983 QHDGGSYSASFRPTTVGRHLISVTANDQHINGSPFSCNVFDVSRVSISGLEQQYGPANLGVPVTF 2047
                     .|||...|:..:|....|:               ||.|  ||.|.|..|   |...
plant   749 ---------QFRPPGSGKLSVSNGGEDR---------------RVLI--LEGQVGVIN---PALQ 784

  Fly  2048 SVDAAG----AGEGTLELVVSTDSSTVKAEVVACARGLYDVTFVPQSTEPHYVNITFNEVAVDGS 2108
            |:...|    ||..:|.|  ||.:.          .|:..:. ||...||           |:..
plant   785 SIQYLGNENFAGVDSLRL--STKNK----------NGINHLD-VPVFVEP-----------VNDP 825

  Fly  2109 PFRVDIQQHTQHIQIGSLAAIDFPADDQI-VEIFSPDQKSVPYSINRQTAEFRTHMTGNYTLRFI 2172
            || :::.|:......||.:.|..|..|:. ..:..||..:.|...:.....|...:|..:.|..:
plant   826 PF-INVPQYIMLESNGSESLIFHPERDKFNFSVGDPDLVNFPGGESHFLVTFSLEVTDGFLLTNL 889

  Fly  2173 DRE-----------------------TRQHIGSRTLCV-FDPTLVKITEVSEAFCHRPASIG--V 2211
            ..|                       ..:|:..:...: |..|:.:..::.:...||....|  :
plant   890 PSELINSTELKFKNLFQWQPIQTYAAISKHVNVKASGIRFRGTIRQCNDLMQQLLHRGGENGAVL 954

  Fly  2212 SLNEAGQGDLSALVRC 2227
            :|..:..|:....:.|
plant   955 TLKLSDMGNYGCFLDC 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jbug	NP_001261140.1	CH	60..165	CDD:237981
		CH	172..269	CDD:278723
		CH	281..371	CDD:278723
		IG_FLMN	468..560	CDD:214720
		Filamin	468..554	CDD:279024
		Filamin	557..644	CDD:279024
		IG_FLMN	560..648	CDD:214720
		Filamin	1116..1200	CDD:279024	17/86 (20%)
		IG_FLMN	1119..1198	CDD:214720	14/80 (18%)
		Filamin	1210..1294	CDD:279024	17/95 (18%)
		Filamin	1299..1383	CDD:279024	22/111 (20%)
		IG_FLMN	1310..1389	CDD:214720	20/103 (19%)
		Filamin	1386..1473	CDD:279024	11/90 (12%)
		IG_FLMN	1399..1480	CDD:214720	7/80 (9%)
		Filamin	1477..1563	CDD:279024	8/85 (9%)
		IG_FLMN	1480..1569	CDD:214720	10/88 (11%)
		Filamin	1570..1653	CDD:279024	19/87 (22%)
		IG_FLMN	1575..1659	CDD:214720	19/88 (22%)
		Filamin	1657..1741	CDD:279024	16/85 (19%)
		IG_FLMN	1661..1747	CDD:214720	16/87 (18%)
		Filamin	1756..1830	CDD:279024	12/73 (16%)
		Filamin	1834..1919	CDD:279024	26/140 (19%)
		IG_FLMN	1837..1926	CDD:214720	26/136 (19%)
		IG_FLMN	1936..2023	CDD:214720	11/86 (13%)
		Filamin	1941..2017	CDD:279024	11/75 (15%)
		Filamin	2021..2111	CDD:279024	24/93 (26%)
		IG_FLMN	2025..2114	CDD:214720	25/92 (27%)
		Filamin	2187..2268	CDD:279024	8/44 (18%)
		Filamin	2279..2369	CDD:279024
		IG_FLMN	2285..2375	CDD:214720
		Filamin	2372..2459	CDD:279024
		IG_FLMN	2376..2465	CDD:214720
		IG_FLMN	2474..2561	CDD:214720
		Filamin	2474..2555	CDD:279024
		IG_FLMN	2657..2751	CDD:214720
		Filamin	2657..2745	CDD:279024
		Filamin	2755..2840	CDD:279024
		IG_FLMN	2756..2847	CDD:214720
		Filamin	2847..2937	CDD:279024
		IG_FLMN	2850..2944	CDD:214720
GEX2	NP_001330856.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR38537
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100