Protein Alignment jbug and flna

DIOPT Version :10

• Sequence 1: NP_001261140.1
• Gene: jbug / 43997
• FlyBaseID: FBgn0028371
• Length: 2990
• Species: Drosophila melanogaster
• Sequence 2: NP_001361642.1
• Gene: flna / 779840
• XenbaseID: XB-GENE-6044838
• Length: 2644
• Species: Xenopus tropicalis
• Alignment Length: 3165
• Identity: 715/3165 - (22%)
• Similarity: 1128/3165 - (35%)
• Gaps: 840/3165 - (26%)

  Fly    57 WVEIQANTFRNWVNEHLRETGMQVHDWATDFCDGTCLCALVENLQTRPLKPSWNRRPANQHHYLE 121
            |.:||.|||..|.||||:....::.:...|..||..|.||:|.|..:.:...:|:||..:...||
 Frog    39 WKKIQQNTFTRWCNEHLKCVNKRIANLQVDLGDGLRLIALLEVLSQKKMYRKYNQRPTFRQMQLE 103

  Fly   122 NATTALKSIEADHIKLVNIGNVDIVNGNIKLILGLIWSLIVRYQIG-----------RSKFPPRK 175
            |.:.||:.::.::||||:|.:..||:||:||||||||:||:.|.|.           ..|..|::
 Frog   104 NVSVALEFLDRENIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTPKQ 168

  Fly   176 LMLAWLQAALPDCRITNLTTDWNSGVNLAALLDYCQPGLFPHWRSLDPSQSVRNCTQAMDLAQRE 240
            .:|.|:|..||...:||.:.||.||..|.||:|.|.|||.|.|.|.|.::.|.|..:||..|...
 Frog   169 RLLGWIQNKLPHLPVTNFSRDWQSGRALGALVDSCAPGLCPDWDSWDATKPVDNAREAMQQADDW 233

  Fly   241 FGVPKVLEPEYLASPWLDELSGMTYLSYF----MKPGGPGYNATMRWVNTQVKDPVKNFTTDWND 301
            .|:|:|:.||.:..|.:||.|.|||||.|    :|||
 Frog   234 LGIPQVITPEEIVDPNVDEHSVMTYLSQFPKAKLKPG---------------------------- 270

  Fly   302 GRVMCEIIKGLGGSAPAPEKLSTDPFHYENNIRKAVDAGARLGVQPILTAKDMANPEVEHLGIMA 366
                          ||...||         |.:||...|.  |::|
 Frog   271 --------------APLRPKL---------NPKKARAYGP--GIEP------------------- 291

  Fly   367 YAAHLQWVPPRPPLSDLVSVYLESTSGRVGEPTHFRIDVMSRDISLSSVRCHVVPPSGQPGQPVR 431
                                    |...|.:...|.::.:|  ..:..|..:|..|:|. .:..:
 Frog   292 ------------------------TGNMVKKRAEFTVETIS--AGMGEVLVYVEDPAGH-REEAK 329

  Fly   432 LNAHGEG------VFVPERYGMHEIVV------------EIGEDSLGGHFFRALPRLLQVAPPGM 478
            :.|:.:.      .::|:..|:|::.|            |:..|...|...:     :....||:
 Frog   330 VTANNDKNRTFSVYYIPKVTGLHKVTVLFAGQHIAKSPFEVNVDKSHGDASK-----VTAQGPGL 389

  Fly   479 APCALGSLV------EVLVNATGAPKTEDILVTAVSPTGISHNCPLKKIDEGHS---AIFKPDEA 534
            .|.  |::.      |:.....|..:.|   ||.|.|.|......::..|:|.|   ..:||...
 Frog   390 EPS--GNIANKTTYFEIFTAGAGVGEIE---VTIVDPNGKKDTADVQLEDKGSSTYRCTYKPTME 449

  Fly   535 GIWEIAITYQGRHIQGGPFTCAVFDASGVSV-----HGLD--GAMPLRAHTFEVDARGVGVSGEL 592
            |::.|.||:.|..|...|:|..:..|...:.     .||.  |........|:|..:|.| ||||
 Frog   450 GVYTIYITFAGVQIPKSPYTVTIGQACNPAACRAVGRGLQPKGVRVKETADFKVYTKGAG-SGEL 513

  Fly   593 HVDIVHDKHSLVCSVEKIVENK------YRVTFMPRQNGKYRVYIYFNGYDVKGSPFIMRVGTKG 651
            .|.:...|     ..|:.|:.|      |...:.|...|.|.|.|.:.|.::..|||.::|||:
 Frog   514 KVVVKGPK-----GTEERVKQKDLGDGVYAFEYYPATPGNYIVTITWGGQNIPRSPFEVKVGTE- 572

  Fly   652 RSGKTRSSPLHDSKHRSESPSMHFVSTTNTRHNDYRNSSLSRHNTAERTNSYSPQYSPKLDTTDY 716
             .|:.|.        |:..|.:.  .....:..|:...::                ...:.|..:
 Frog   573 -CGQQRV--------RAWGPGLE--GGVVGKSADFVVEAI----------------GDDVGTLGF 610

  Fly   717 HSSSSRYYKRESEENHATPPPAPPPASGSPTVKY--LNSADLYTETLNGRRDSKTS----NSSST 775
            ........|.|.::.          ..||..|:|  |...:.....|....|.|.|    :....
 Frog   611 SVEGPSQAKIECDDK----------GDGSCDVRYWPLEPGEYAVHVLCNNEDIKLSPFMADIKPA 665

  Fly   776 KNDYYYDKENE----LYSQRRAVTKPKLTPPREERELTSTTNTSSSSSFQQRHQQLATSTLTRSL 836
            ..|:|.:|...    |.....|:.||                              |..|:...|
 Frog   666 PKDFYPEKVKAYGPGLEKTGLAINKP------------------------------AEFTVDAKL 700

  Fly   837 SPIPSPTLNTRSSEVHTHSPLTIKTSNQYESSTRNITSSPRHASVSPVQRYS---------PNSA 892
            .......::.:.||   .:|:.:.|.:     ..|.|.|..:....|::..:         |||.
 Frog   701 GGKAPLKVSVQDSE---GTPVDVTTKD-----NGNGTYSCSYLPKKPLKHTAVVSWGGVNIPNSP 757

  Fly   893 Y---ITTATHRMGSPLTSP-VSKNGYESSRTVEKSSTYKSTSNYVTDSNIRASPSLYGTAERLRR 953
            :   |...:|.....:..| |:|.|.::......:..............|:.:|.:.|.||
 Frog   758 FRMTIGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPAE---- 818

  Fly   954 TGSPEPRIDHSSNVRVSSMKPASARRDSWDVINKTKHMLSHNSLESLANMTEKQLNTELQYNRPD 1018
                                                                           .|
 Frog   819 ---------------------------------------------------------------AD 820

  Fly  1019 LDHETHRNTQYNKFALHKQQQQQSDYRRDSPDDGERYKPSAITVKSHSNNTYTDK-----SGGYT 1078
            :|.:..||                                       .|:|:|.|     :|.||
 Frog   821 IDFDIIRN---------------------------------------DNDTFTVKYTPPGAGSYT 846

  Fly  1079 KTV--------------KESSEHVVTESNGHGPSPGYGYSSLSRFRPIDGNATGARAIRVQDIPN 1129
            ..|              |....|..::....||..               |.:|.
 Frog   847 IMVLFADQATPMSPFRIKVDPSHDASKVKAEGPGL---------------NRSGV---------- 886

  Fly  1130 GSIGRPVEFEIDGSRAGSGNLEILVNGGRVTSSVRSLG-----GQRFIASFTPHEHGTHTVQITF 1189
             .||:|..|.::...||..||::...|.....:|:...     ...:...:||.:.|...|.:|:
 Frog   887 -EIGKPTHFTVNTKAAGKANLDVQFTGPAKGEAVKDFDVIDNHDNTYTVKYTPVQQGNMGVNVTY 950

  Fly  1190 NGETVPGSPWHAEI-----MSSPGLTALGESTRLVPANTPAVFEILPPPGQSLSKGECVATVLTP 1249
            .|:.:|.||:...|     :|...::.||:... |..:.....:.....||    |:....:..|
 Frog   951 GGDHIPKSPFTVGIAPTLDLSKIKVSGLGDKVE-VGKDQEFTVKSRGAGGQ----GKVACKITGP 1010

  Fly  1250 SKSKLNARVTHEAANGAARIEFVPTEVGTHVIDASINGTKIAGGPLIAKVYDSSLIQVTE----- 1309
            |...:..:|....:...:.::|:|.|.|.:.:|.:.:|..|.|.|...:...|:.....:
 Frog  1011 SNKSVPCKVEPGLSPDNSTVKFIPREEGPYEVDVTYDGVPIPGSPFPVEAVPSTNPSKVKAFGPG 1075

  Fly  1310 VNGGVVGQACQFRVDASAAGEGQLEISINEGEVPNHVQVV--GGGRCLVSFTPEQAKSHLIDIKF 1372
            :.||.||.:..|.:|...||:|.|.::: ||.....::.:  |.|.|.||:.|.:...:.|:|.|
 Frog  1076 LKGGSVGSSAPFTIDTKGAGQGGLGLTV-EGPCEAKIECLDNGDGTCSVSYLPTERGDYNINILF 1139

  Fly  1373 NGETVRGCPFVCAVA---DTSRVLLNLSNLELIPVNRPSSFHITVSGGGAAELAVSV---RGPQG 1431
            ....:.|.||...|.   |.|:|..:...||...|.....|::..|..|:|||.:.:   .|.|.
 Frog  1140 ADTHIPGSPFKAKVEPCFDPSKVTCSGPGLEHAQVGEAGKFNVDCSNAGSAELTIEIISDNGMQA 1204

  Fly  1432 ELPVRVTGDIHAGFTAEFTPTTVGGHSINVEYNGFAVQGTPF---LAKSYDASKVVVGSVSRGTM 1493
            |:.::..||  ..:|..:.|...|.::|.::|.|..|...|.   :..:.|.|.|.|  ...|..
 Frog  1205 EVHIQDNGD--GTYTITYIPLYPGVYTITIKYGGQMVPNFPSKLQVKPAIDTSGVKV--YGPGVE 1265

  Fly  1494 GRPV------QFTVDA---GDAGEGNLEITISAKGQNIPTQ-VHPQGSARFSVSFVPTESCEHTI 1548
            |:.|      .|.|||   ..:|..:|:..:|....|.... |...|...:.|.:.|.|...|::
 Frog  1266 GKGVFREATTDFNVDARALTKSGGPHLKTVVSNPSGNFTEAFVQDNGDGTYKVEYTPYEEGIHSV 1330

  Fly  1549 NVSFNKMPVPGCPITVSISGGVAGPQVSLGGPGPV----HQTNSFVINHNGGRLEDIEVNVEGPA 1609
            :|.::..|.|..|..|.::.|....:|.:.|||.|    :|.|.|.:...|.....:.:.||||:
 Frog  1331 DVIYDGSPAPKSPFVVPVTEGCDPSRVRVHGPGIVSGTTNQPNKFTVETRGAGTGGLGLAVEGPS 1395

  Fly  1610 GQSVPAQVHQSADGVFKAEFVPRVVGEHRVNVTVNGLPTAGSPYAAKVYD-VSAIKVK----NVS 1669
            ...:...  .:.||....|:||...|.:.:|||..|....|||:...|.| |.:.|||    .:|
 Frog  1396 EAKMSCT--DNKDGSCSVEYVPYEPGTYNLNVTYGGHQVPGSPFKVPVSDVVDSSKVKCTGPGLS 1458

  Fly  1670 SGTVGKAV--TFLVETSQAGPGNLEVTVNGGR---VPTSAQAQGQHTYAISFTPREAESHTVELR 1729
            .|.|...|  :|.|:||:||...|:|.|.|.:   .|......|.....:::.|.....:.:.:.
 Frog  1459 PGLVRANVPQSFSVDTSKAGVAPLQVKVQGPKGIVEPVEIVDNGNGVQTVNYVPTREGPYNISVL 1523

  Fly  1730 FNSQDVPGSPFTCRV-----AAAARIQSPE-TMDKVSVGRLFEFVVESDTKP------TVEVLGP 1782
            :...::|.|||..||     |:..:...|. ....|......||.:  |.|.      .|::..|
 Frog  1524 YGDDEIPHSPFKVRVLPTHDASKVKASGPGLNTTGVPASLPVEFTI--DAKDAGEGLLAVQITDP 1586

  Fly  1783 ARRSVPVKIDALGSSTLGYNVKFEPMEVGDHSVEVRLPGGGHVEGSPFLLKAY---SAEKVIVT- 1843
            ..:  |.|.....:....|.|.:.|...|.:::.::. ||..:..||:.::|.   .|.|..||
 Frog  1587 EGK--PKKATIRDNQDGTYTVSYVPDMTGRYTILIKY-GGDEIPYSPYRIRALPTGDASKCTVTV 1648

  Fly  1844 -----DIRAGV-----VNKSVSFGINASQAGAGNLEIIVAV-NGKNVPNFVQSEGNARFKVNFKP 1897
                 .:.||:     :.:.....::|..||.|.:...|.. :|..|...|....:..|.:.:..
 Frog  1649 SIGGHGLGAGIGPTIQIGEETVITVDAKAAGKGKVTCTVCTPDGTEVDVDVVENEDGTFDIFYTA 1713

  Fly  1898 TEAATHSLSVRFNGHPVPGSPFSC----------------HIAAAAASPSMGLPRAM---AMGEC 1943
            .:...:.:.|||.|..:|.|||..                .:|...|.|.|..|.|.   .||.
 Frog  1714 PQPGKYVICVRFGGEHIPNSPFQVTALDGEQMMPQQMVQQQLAPPYAYPGMQQPWATDRPVMGV- 1777

  Fly  1944 LKQAAVKMDNTFELEG---FDGVEPQIF--------VTSPSGDNEHCQLSQHDGGSYSASFRPTT 1997
                     |..::.|   ||.|.|...        |..|||......::.:..|:.:..:.||.
 Frog  1778 ---------NGLDVAGLRPFDLVIPFTIKKGEITGEVRMPSGKVAKPDITDNKDGTVTVRYAPTE 1833

  Fly  1998 VGRHLISVTANDQHINGSPFSCNVFDVSRVSISGLEQQYGP----ANLGVPVTFSVDAAGAGEGT 2058
            .|.|.:.:..:..||.|||..   |.|..|: ||....|||    ..:..|..|:|:...||||.
 Frog  1834 AGLHEMDIKYDGMHIPGSPLQ---FYVDYVN-SGHVTAYGPGLIHGTVNKPAVFTVNTKDAGEGG 1894

  Fly  2059 LELVVSTDSSTVKAEVVACA---RGLYDVTFVPQSTEPHYVNITFNEVAVDGSPFRV----DIQQ 2116
            |.|.:...|   ||| ::|.   .|...|:::|.....:.:.:.:|...:.||||..    |...
 Frog  1895 LSLAIEGPS---KAE-ISCTDNQDGTCTVSYLPVLPGDYNILVKYNNKHIPGSPFVAKITGDDSM 1955

  Fly  2117 HTQHIQIGSLAAIDFPADDQIVE---------IFSPDQKSVPYSINRQTAEFRTHMTGNYTLRFI 2172
            ....:::||  |.|.|.:  |||         :.||..:..|..:.|.       ..|:..:.|:
 Frog  1956 RMSQLKVGS--AADIPLN--IVETDLSQLTATVTSPSGREEPCLLKRL-------RNGHVGISFV 2009

  Fly  2173 DRETRQHIGSRTLCVFDPTLVKITEVSEAFCHRPAS-IGVSLNEAGQGDLSALVRCGATEVPHTI 2236
            .:||.:||.|               :.:...|.|.| |.|.::::..||.|.::
 Frog  2010 PKETGEHIVS---------------IKKNGIHIPNSPITVMISQSEIGDASRVI----------- 2048

  Fly  2237 RGPSKTGVYEIVYQPTRVAPHKISILFNEVPISLKPLEINVLPASAGKEISVSGLGLYQSRVGKT 2301
                                                               |||.||.:.|..:.
 Frog  2049 ---------------------------------------------------VSGQGLTEGRTFEP 2062

  Fly  2302 TSFAIDTVKRPAREFDVVVSGPGGQALPVRCYQTKNGHLQAEFTINKPGQCVIEVLHQSKPLPGS 2366
            ..|.|||.:.......:.:.||  ..:.:.....::|..:..:...:||..:|.:....:.:|||
 Frog  2063 AEFIIDTREAGYGGLSLSIEGP--SKVDINTEDLEDGTCKVTYCPTEPGNYIINIKFADQHVPGS 2125

  Fly  2367 PFTCESFDSSKVSTQGVTKEPLA----------LHSPNSFTVRTDNAGTAELEAFAISPSNQSIP 2421
            ||      |.||:.:|..||.:.          :.|....:::.......::.|...|||.:...
 Frog  2126 PF------SVKVTGEGRMKESITRRRTAPSVANIGSQCDLSLKIPEISIHDMTAQVTSPSGKIHD 2184

  Fly  2422 VLISEQSDGVYNVEFVPSQPGNYKLTLMYGGETIPSSPLNFTAS--SSGVRNDARAAGHGLEVCH 2484
            ..|.|..:..|.:.||||:.|.:.:::.|.|:.:|.||..||..  ..|..:..||.|.|||...
 Frog  2185 AEIMESENNTYCIRFVPSEMGVHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAE 2249

  Fly  2485 RNKEASFVVYCPIAPNVQIERLDEYGERIEPKIKALGNNEWRISYTILSVGKYEIRASCPNRGSL 2549
            ....|.|.::...|....:....|...:.|...:...:....:||.:...|.||:.... |...:
 Frog  2250 VGTPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYIVQEPGDYEVSVKF-NDEHI 2313

  Fly  2550 PGSPWHISCVESNKVTPVGGWGTLVDHDGRLILPARIIFDVENAGPGKLVCSIDGIEIPVDKLVD 2614
            |.||:         |.|||.    ...|.|
 Frog  2314 PDSPF---------VVPVGS----TSDDAR----------------------------------- 2330

  Fly  2615 GKMCLNITGENLAAGEHDLDLTWSGLTITQCPRSAFVTGQQAADKVQLMGRGLAAAQAGEAAHFT 2679
                                    .||::....|.....|.|:..|.|.|           |...
 Frog  2331 ------------------------RLTVSSLQESGLKVNQPASFAVSLNG-----------AKGV 2360

  Fly  2680 IDAS-NAPAGR-PEVILTSQDNTSLPVSLAQPRPSENIWLASYTPLKSTTGTLNLSVKWNGRLVK 2742
            :||. ::|:|. .|..:|..|.....|...   |.||             |...:.||:||..:.
 Frog  2361 LDAKVHSPSGALEECCVTEIDEDKYAVRFI---PREN-------------GLYIVDVKFNGSHIP 2409

  Fly  2743 GCPLTVAV---GSSMDASKVIVSGEGLRHGIVGKDIKSWIDTRRAGPGELTAHCAGVRKVAY-CE 2803
            |.|..:.|   |.:.|...|...|.||..|..|...:..::|.:||||.||....|..||.. |:
 Frog  2410 GSPFKIRVGEPGQAGDPGMVSAYGPGLEGGTTGSAAEFIVNTTKAGPGALTVTIDGPSKVKMDCQ 2474

  Fly  2804 LYDHG-DATFTLNIKPQESGRHILTIKYGG-QNVPGSPFALKVAG-------------------- 2846
            ....| ..|:|    |...|.::::||||| .::.||||..||.|
 Frog  2475 ECAEGYKVTYT----PMAPGSYLISIKYGGPYHIVGSPFKAKVTGPRLVTSHSLHESSSVFVDSV 2535

  Fly  2847 ---------------APDASKVRVYGPGIEHGVLATFQSRFICDTRGAGAGQLTVRVRGPKGAFR 2896
                           |.|||||...|.|:....:.. ::.|..|...||...|.|.|.|||....
 Frog  2536 TKSEAFTQHAAAPRIASDASKVVAKGLGLNKAFVGQ-KNSFTVDCSKAGNNMLLVGVHGPKTPCE 2599

  Fly  2897 VEMQRESQKDRTILCKYDPTEPGDYRVEVKWAGEFVPGSPFPVMI 2941
             |:..:...:|.....|...:.|||.:.|||..|.:.|||:.|.:
 Frog  2600 -EIVVKHLGNRLYNVTYLLKDKGDYILVVKWGDEHILGSPYHVSV 2643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jbug	NP_001261140.1	CH_jitterbug-like_rpt1	57..166	CDD:409076	47/108 (44%)
		CH_jitterbug-like_rpt2	170..274	CDD:409078	47/107 (44%)
		CH_jitterbug-like_rpt3	275..373	CDD:409034	10/97 (10%)
		IG_FLMN	468..560	CDD:214720	25/100 (25%)
		IG_FLMN	560..648	CDD:214720	27/100 (27%)
		IG_FLMN	1119..1198	CDD:214720	17/83 (20%)
		IG_FLMN	1220..1302	CDD:214720	15/81 (19%)
		IG_FLMN	1310..1389	CDD:214720	25/83 (30%)
		IG_FLMN	1399..1480	CDD:214720	22/86 (26%)
		IG_FLMN	1480..1569	CDD:214720	25/98 (26%)
		IG_FLMN	1575..1659	CDD:214720	27/87 (31%)
		IG_FLMN	1661..1747	CDD:214720	27/99 (27%)
		IG_FLMN	1757..1837	CDD:214720	18/88 (20%)
		IG_FLMN	1837..1926	CDD:214720	24/116 (21%)
		IG_FLMN	1936..2023	CDD:214720	23/100 (23%)
		Filamin	2021..2111	CDD:395505	29/96 (30%)
		IG_FLMN	2198..2280	CDD:214720	8/82 (10%)
		IG_FLMN	2285..2375	CDD:214720	21/89 (24%)
		IG_FLMN	2376..2465	CDD:214720	25/98 (26%)
		Filamin	2474..2555	CDD:395505	20/80 (25%)
		IG_FLMN	2657..2751	CDD:214720	23/98 (23%)
		IG_FLMN	2756..2847	CDD:214720	34/128 (27%)
		IG_FLMN	2850..2944	CDD:214720	30/92 (33%)
flna	NP_001361642.1	CH_FLNA_rpt1	24..151	CDD:409157	48/111 (43%)
		CH_FLNA_rpt2	154..267	CDD:409161	45/112 (40%)
		IG_FLMN	279..373	CDD:214720	19/141 (13%)
		IG_FLMN	379..475	CDD:214720	25/105 (24%)
		IG_FLMN	478..570	CDD:214720	26/97 (27%)
		IG_FLMN	576..665	CDD:214720	16/124 (13%)
		IG_FLMN	671..765	CDD:214720	20/131 (15%)
		IG_FLMN	768..868	CDD:214720	22/205 (11%)
		IG_FLMN	871..967	CDD:214720	24/121 (20%)
		IG_FLMN	971..1063	CDD:214720	19/96 (20%)
		IG_FLMN	1066..1155	CDD:214720	25/89 (28%)
		IG_FLMN	1159..1251	CDD:214720	24/93 (26%)
		IG_FLMN	1255..1351	CDD:214720	25/97 (26%)
		IG_FLMN	1354..1443	CDD:214720	27/90 (30%)
		IG_FLMN	1448..1541	CDD:214720	26/92 (28%)
		IG_FLMN	1544..1638	CDD:214720	20/98 (20%)
		IG_FLMN	1664..1742	CDD:214720	17/77 (22%)
		IG_FLMN	<1794..1858	CDD:214720	15/66 (23%)
		IG_FLMN	1865..1951	CDD:214720	25/89 (28%)
		IG_FLMN	2044..2133	CDD:214720	25/158 (16%)
		IG_FLMN	2235..2323	CDD:214720	22/97 (23%)
		IG_FLMN	2329..2420	CDD:214720	29/176 (16%)
		IG_FLMN	2426..2516	CDD:214720	33/93 (35%)
		IG_FLMN	2554..2643	CDD:214720	30/90 (33%)