DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment jbug and Dys

DIOPT Version :9

Sequence 1:NP_001261140.1 Gene:jbug / 43997 FlyBaseID:FBgn0028371 Length:2990 Species:Drosophila melanogaster
Sequence 2:NP_001036722.1 Gene:Dys / 42327 FlyBaseID:FBgn0260003 Length:3598 Species:Drosophila melanogaster


Alignment Length:2715 Identity:493/2715 - (18%)
Similarity:850/2715 - (31%) Gaps:880/2715 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 IQANTFRNWVNEHLRETG-MQVHDWATDFCDGTCLCALVENLQTRPLKPSWNRRPANQHHYLENA 123
            ||..||..|:|.||.:|. ..|.|...|..||..|.||:..|....|||...|.   :.|::.|.
  Fly    13 IQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNLKPEKGRM---RVHHINNL 74

  Fly   124 TTALKSIEADHIKLVNIGNVDIVNGNIKLILGLIWSLIVRYQ-----IGRSKFPPRKLMLAWL-Q 182
            ...:..|:...:|||||.:.|||.||.||.|||||.:.:.:.     ...|.....|.:|||. |
  Fly    75 NKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKSHSSNGVEKSLLAWARQ 139

  Fly   183 AALP-DCRITNLTTDWNSGVNLAALLDYCQPGLFPHWRSLD-----PSQSVRNCTQAMDLAQREF 241
            ...| ..::.:.::.|:.|.....:||       .|...|:     ...:::....|.|||.|.|
  Fly   140 YTEPHGLQLNDFSSSWSDGRAFLMILD-------AHVEELNLQAALQQHALKRLHLAFDLAHRHF 197

  Fly   242 GVPKVLEPEYLASPWLDELSGMTYLSYFMKPGGPGYNATMRWVNTQVKDPVKNFTTDWNDGRVMC 306
            .:.|:|:.|.:.:...|..|...|:...       |:| |..:.|:.::..::...|.:.|||.|
  Fly   198 KIEKLLDAEDVHTHKPDNKSIQMYVMCL-------YHA-MESMRTRQQEQEQDEGQDQDPGRVPC 254

  Fly   307 EIIKGL----------------GGSAPAPEKLSTDPFHYENNIRKAVDAGARLGVQPILTAKDMA 355
            ..|..|                ..||.:.|:.|:......:             ::|:.||   .
  Fly   255 TSITDLDEVPLDNDQTSLGLYTSDSAGSMEQRSSGELKTHS-------------MRPLSTA---T 303

  Fly   356 NPEVEHLGIMAYAAHLQWVPPRPPLSDLVSVYLESTSGRVGEPTHFRIDVMSRDISLSSVRCHVV 420
            |..||   |..|.:.|:.|         :::.||..            .::|:::          
  Fly   304 NASVE---ISGYQSALEAV---------LTLLLEDE------------QLLSQNL---------- 334

  Fly   421 PPSGQPGQPVRLNAHGEGVFVPERYGMHEIVVE--------IGEDSLGG--------HFFRALPR 469
             |..|..|..:|..|....|:.:.....|.|.|        |.|....|        :..|....
  Fly   335 -PDPQDFQTAKLQFHENESFMLKLTEHQEYVGEALEEGSNLINESQKAGAGLSQEDQNEVRQQMV 398

  Fly   470 LLQVAPPGMAPCALGSLVEVLVNAT--GAPKTEDI--LVTAVSPTGISHNCPL-KKIDEGHSAIF 529
            ||......:...||....::|:...  ...|.|.:  .:|:|... |||...: ..::|....:.
  Fly   399 LLNERWETLRLRALDVQAKILMRLAEFQKQKLEQLRQFLTSVEDR-ISHMSDIGPTLEEAEKQLL 462

  Fly   530 KPDEAGIWEIAITYQGRHIQG-GPFTCAVFDASGVSVHGLDGAM--------------PLRAHTF 579
               ||...:..::.|...:.. ......|.|.|| :.:.|:..:              .||....
  Fly   463 ---EAQKLKADLSEQQELVDSLSSMVVIVNDTSG-NFNDLEDRLSALGERWSHVVKWSDLRKEKL 523

  Fly   580 E--------VDARG-----------VGVSG------ELHVDIVHDKHSLVCSVEKIVENKYRV-- 617
            :        :|||.           ..|.|      ||:          .|:.:.:...:|.:  
  Fly   524 QQYKCISRWLDAREQDLKLMESRDVTDVGGITQRINELN----------YCAKDLLELQRYLIDL 578

  Fly   618 ------TFMPRQNGKYRVYIYFNGYDVKGSPF-------IMRVGTKG-RSGKTRSSPLHDSKHRS 668
                  |.....:...||.|....|:.:....       .:|:.||| ..|:.|:| ..||:...
  Fly   579 RQMVAATLQDGDDKGERVLIQLESYEDRLDALKQIVEVQTVRIETKGFNFGRDRAS-YDDSRVVR 642

  Fly   669 ESPSMHFVSTTNTRHNDYRNSSLSRHNTAERTNSYSPQYSPKLDTTDYHSSSSRYYKRESEENHA 733
            ....:.:........:|.:... ..|:.|.:..        ||...|..::.         |||.
  Fly   643 PEGWVDYQMIIRFGEDDSQEDD-DEHDLASKKR--------KLRNADNFNAL---------ENHI 689

  Fly   734 TPPPAPPPASGSPTVKYLNSADLYTETLNGRRDSKTSNSSSTKNDYYYDKENELYSQRRAVTKPK 798
                       .....|:...:...:.|         ...|.:......||.:..:.||..|.|:
  Fly   690 -----------MEHFGYVQEVEQKLQQL---------QRQSLRQQCELLKELQAENSRRCGTLPE 734

  Fly   799 LTPPREERELTSTTNT-----SSSSSFQQRHQQLATSTLTRSLSPIPSPTLNTRSSEVHT----- 853
            |....|..||...:..     :.....:||:..|             |..|:::.||.||     
  Fly   735 LKKLYEVCELEDPSRNLLLEETHIKQLEQRYANL-------------SQKLSSQQSESHTLLAKE 786

  Fly   854 --HSPLT------IKTSNQYESSTRNITSSPRHASVSPVQRYSPNSAYITTAT------------ 898
              ::.||      ..:.:.|:....:.:.:.....:|.::..:...:...|||            
  Fly   787 KYYNSLTGFKLVLADSRDWYKQHAGSASGNELEQRLSHMESLASEISEAKTATEELDDNLIEWKQ 851

  Fly   899 ---------HRMGSPLTSPVSKNGYES-SRTVEKSSTYKSTSNYVTDSNIRASPSLYGTAERLRR 953
                     |.|...|.:.:.:.|.|| ||.:::...:.:.   |::..:|.| :|....|:   
  Fly   852 DFGLFYDSWHDMKQALQALIQQRGGESLSRQLKQIQDFVTK---VSNQKVRVS-NLEVMQEQ--- 909

  Fly   954 TGSPEPRIDHSSNVRVSSMKPASARRDSWDVINKTKHMLSHNSLESLANMTEKQLNTELQYNRPD 1018
                    .|..|..:..|:   :.|.::|  |..||::. ..|::..|...:|||..:......
  Fly   910 --------QHFLNQLLDEME---SLRLTYD--NIPKHLIG-EELQTAWNRLPEQLNERVIKQTTA 960

  Fly  1019 LDHETHRNTQYNKFALHKQQQQQSDYRRDSPD-----DGERYKPSAITVKSHSN----------- 1067
            :::..|...:||  |:....:..:|.:.:..|     |..:.:...|:.::.|.           
  Fly   961 IENLNHFAAEYN--AIIAMLRSAADSKLNGSDGASSQDLRKLEIDVISARNFSEILIKEAEPAQK 1023

  Fly  1068 ----------NTYTDKSGGYTKTVKES----SEHV-------------VT--ESNGHGPSPGYGY 1103
                      ||..|:.....:..||.    ..|:             :|  |||    :|..|.
  Fly  1024 ESLQSQIRALNTLYDQVEQVHREKKEQQTVLQSHIDLIQLRLKETDQWLTDLESN----TPKSGI 1084

  Fly  1104 SSLSRFRPIDGNATGARAIRVQDIPNGSIGRPVEFEIDGSRAGSGNLEILVNGGRVTSSVRSLGG 1168
            |.:     ::.|.......|.|.:.........:|.....|.|    |:|:....:....|.   
  Fly  1085 SDI-----VNSNELFQSKSRFQTLKETCERETTQFRDLNERGG----ELLLQMDELQDQDRE--- 1137

  Fly  1169 QRFIASFTPHEHGTHTVQIT-FNGETVPGSPWHAEIMSSPGLTALGESTRLVPANTPAVFEILPP 1232
                     ..:|:...|.| .|..      |             .|.|.||.|.|..:..|   
  Fly  1138 ---------SRYGSLAKQFTRINAR------W-------------TEVTELVYAKTALLEHI--- 1171

  Fly  1233 PGQSLSKGECVATVL--TPSKSKLNARVTHEAANGAARIEFVP--------------------TE 1275
               |...||....::  |....||..::.:...|.|...|.:.                    .|
  Fly  1172 ---STQLGEFKKFMVSETGYLDKLENKIRNTPENAADAEEIMEELDDLENVLRSHSEEWLDKIQE 1233

  Fly  1276 VGTHVIDASINGTKIAGGPLIAKVYDSSLIQVTEVNGGVVGQACQFRVDASAAGEGQLEISINEG 1340
            :|..:||.......      |.:..|.::.:.|::.     |..:.|.:.       ||..::|.
  Fly  1234 IGNELIDNEFMADS------IRRDIDETVQRWTQLQ-----QQAKKRTEL-------LEQKVSEA 1280

  Fly  1341 EVPNHVQVVGGGRCLVSF-----------------------TPEQAK----------------SH 1366
            |...        :|:|.|                       .||:.:                |.
  Fly  1281 EQSE--------KCIVQFEKWLTRVDDILSDHLDNDVTIVDQPEEFQRLAHEFVANEKNFKEISE 1337

  Fly  1367 LID------------------------IKFNGETVRGCPFVCAVADTSRVLLNLSNLELIPVNRP 1407
            |||                        .|:....:..|   .|:..:....||.:..:|..|.| 
  Fly  1338 LIDEHTRNGKVGAANRLQEQLNLMEVRFKYCQAKLSKC---TAIQHSYESRLNRAYTDLRNVER- 1398

  Fly  1408 SSFHITVSGGGAAELAVSVRGPQGELPV-RVTGDIHAGFTAEFTPTTVGGHSI-NVEYNGFAVQG 1470
            |:..:.|:..|...:....   |..|.: |...:|    .:|...|...|..: ...|.....| 
  Fly  1399 STEVVDVASAGPNTVQTQY---QKCLQIYRTLSEI----KSEIESTIKTGRRVCEDRYTKSPKQ- 1455

  Fly  1471 TPFLAKSYDASKVVVGSVSRG------------TMGRPVQFTVDAGDAGEGNLEITISAKGQNIP 1523
               |::..||.|.:..::...            |:.|.::...|:.|    ||     .:....|
  Fly  1456 ---LSQRIDALKHLYNTLGENVTQSKATLERLLTLARQLEECFDSAD----NL-----IRRFESP 1508

  Fly  1524 TQVHPQGSARFSVSFVPTESCEHTINVSFNKMPVPGCPITVSISGGVAGPQVSLGGPGPVHQ-TN 1587
            .:||.:.|.......| ...||...| .:||.....|.:...        |...|.....|: |:
  Fly  1509 QEVHDRNSILLEFEDV-LRRCEDHYN-EYNKSCDQSCMVETR--------QRIDGLKATYHKLTS 1563

  Fly  1588 SFVINHNGGRLEDIEV---NVEGPAGQSVPAQVHQSADGVFKAEFVPRVVGEHRVNVTVNGLPTA 1649
            :.:|.    ||.:::.   |::..:.:::.|..|...:                :||..|     
  Fly  1564 ADIIK----RLTEMKTTLQNLDNISLETLRAMEHDLKE----------------INVPSN----- 1603

  Fly  1650 GSPYAAKVYDVSAIKVKNVSSGTVGKAVTFLVETSQAGPGN--LEVTV-------------NGGR 1699
              |...|:.......|.:|......:|.| |...:.:.|.|  .|:.|             ..|.
  Fly  1604 --PEIEKLQQQVIAIVVDVLKTRFNEATT-LAARNTSSPDNDDTEIVVVSDTVRQRRARTPQSGE 1665

  Fly  1700 VPTSAQAQGQH--TYAISFTP-----------------REAESHTV--ELRFNSQDVPGSP---- 1739
            .|:||......  |..:..:|                 |.|||.|:  ::..|.|.|..:|    
  Fly  1666 SPSSAHTSSSESPTKGVENSPGAVGDQVMPDLLPPQTFRLAESSTLFSQISLNPQKVTNTPPPKP 1730

  Fly  1740 -FTCRVAAAARIQSPETM------DKVSVGRLFEFVVESDTKPTVEVLGPARRSVPVKIDALGSS 1797
             .|.|.|.::..|..|..      ||:||..:.....:.:...||.:|......||..::.:...
  Fly  1731 AKTKRKAPSSPAQVVEIRVKNIQNDKMSVQNIDLEPQQGEIVDTVNILESVEPFVPEYVETVQIV 1795

  Fly  1798 TLGYNVKFEPMEVGDHSVEVRLPGGGHVEGSPFLLKAYSAEKVIVTDIRAGVVNKSVSFGINASQ 1862
            .|.        |..|.||.|...|       ..:.::.|...:..|.:      ..||   :..:
  Fly  1796 DLS--------EDSDSSVRVDSQG-------KEMRRSKSKHSLNETPL------PKVS---DNDE 1836

  Fly  1863 AGAGNLEIIVAVNGKNVPN-FVQSEGNARFKVNFKPTEAATHSLSVRFNGHPVPGSPFSCHIAAA 1926
            ..|...|.::..:.:|... |::.| ..|...:.|....|.....:|.:....|.:|        
  Fly  1837 DSAEQEEDLLRPSAENTSTPFLRVE-KRRISFDEKRKRVANERDILRDSEEEEPKTP-------- 1892

  Fly  1927 AASPSMGLPRAMAMGECLKQAAVKMDNTFELEGFDGVEPQIFVTSPSGDNEHCQLSQHDGGSYSA 1991
                  ..|||..:.:..:...::.:       .|.:||:    ||..|:.:             
  Fly  1893 ------DTPRAAQVSKPKRWRQLQPE-------MDALEPE----SPGRDSFY------------- 1927

  Fly  1992 SFRPTTVGRHLISVTANDQHINGSPFSCNVFDVSRVSISGLEQQYGPANLGVPVTFSVDAAGAGE 2056
                                   ||...:.||..                  |:.|| |......
  Fly  1928 -----------------------SPDKESGFDAE------------------PLVFS-DDEDIPR 1950

  Fly  2057 GTLELVVSTDSSTVKAEVVACARGLYDVTFVPQSTEPHYVNITFNEVAVDGSPFRVDIQQHTQHI 2121
            .:||:..:.||.:..:.::           .|.:..|              :||...:       
  Fly  1951 FSLEMTSTIDSDSDTSRIM-----------TPSTKNP--------------NPFLSKV------- 1983

  Fly  2122 QIGSLAAIDFPADDQIVEIFSPDQKSVPYSINRQTAEFRTHMTGNYTLRFIDRETRQHIGSRTLC 2186
                |.::..|.||..|.:.||..:..|.:::.:..||             |::.:|.|..    
  Fly  1984 ----LESLSSPVDDSNVTLKSPISEEQPQNLDDRVREF-------------DKQAKQMIYK---- 2027

  Fly  2187 VFDPTLVKITEVSEAFCHRP----------------ASIGVSL---NEAGQGDLSALV------- 2225
                  :|:|:.....||..                .|.|.||   ....||.:|.||       
  Fly  2028 ------LKLTKAKIEQCHESEAEDLRLLIAPDAATLISQGDSLVLETHGRQGSISRLVMRTQIIL 2086

  Fly  2226 RCGATEVPHTIRGPSKTG----------VYEIVYQPTRVAPHKISILFNEVPISLKPL------- 2273
            |....||.......|.:|          :.|:|.:..|    :|::|. |..:.||..       
  Fly  2087 REQFREVQQARSKTSGSGAPAPPLDSVNIEELVTKGLR----RINVLI-EKTVDLKSSTDLEKRM 2146

  Fly  2274 --------EINVLPASAGKEISVSGL-GLYQSRVGKTTSFAI---DTVKRPAREFDVVVSGPGGQ 2326
                    ::.|:.::.||...:..: .|..:.:.||.:..|   |:::....|   :.:||   
  Fly  2147 EDINERHDDLQVIVSAIGKNAQMPKVTPLMMNEIEKTKNNLIAHADSIELSLTE---LRNGP--- 2205

  Fly  2327 ALPVRCYQTKNGHLQAEFTINKPGQCVIEVLHQSKPLPGSPFTCESFDSS 2376
                   :..||..:.:.:......|..|  :.::| .|:.....|||.|
  Fly  2206 -------RISNGKERPDASSAATMSCRSE--YNNEP-SGTGALAGSFDKS 2245

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
jbugNP_001261140.1 CH 60..165 CDD:237981 42/105 (40%)
CH 172..269 CDD:278723 24/103 (23%)
CH 281..371 CDD:278723 21/105 (20%)
IG_FLMN 468..560 CDD:214720 17/97 (18%)
Filamin 468..554 CDD:279024 16/91 (18%)
Filamin 557..644 CDD:279024 21/140 (15%)
IG_FLMN 560..648 CDD:214720 20/141 (14%)
Filamin 1116..1200 CDD:279024 12/84 (14%)
IG_FLMN 1119..1198 CDD:214720 12/79 (15%)
Filamin 1210..1294 CDD:279024 20/105 (19%)
Filamin 1299..1383 CDD:279024 19/146 (13%)
IG_FLMN 1310..1389 CDD:214720 18/141 (13%)
Filamin 1386..1473 CDD:279024 17/88 (19%)
IG_FLMN 1399..1480 CDD:214720 16/82 (20%)
Filamin 1477..1563 CDD:279024 20/97 (21%)
IG_FLMN 1480..1569 CDD:214720 19/100 (19%)
Filamin 1570..1653 CDD:279024 13/86 (15%)
IG_FLMN 1575..1659 CDD:214720 14/87 (16%)
Filamin 1657..1741 CDD:279024 24/124 (19%)
IG_FLMN 1661..1747 CDD:214720 27/126 (21%)
Filamin 1756..1830 CDD:279024 16/79 (20%)
Filamin 1834..1919 CDD:279024 14/85 (16%)
IG_FLMN 1837..1926 CDD:214720 14/89 (16%)
IG_FLMN 1936..2023 CDD:214720 10/86 (12%)
Filamin 1941..2017 CDD:279024 7/75 (9%)
Filamin 2021..2111 CDD:279024 13/89 (15%)
IG_FLMN 2025..2114 CDD:214720 12/88 (14%)
Filamin 2187..2268 CDD:279024 24/116 (21%)
Filamin 2279..2369 CDD:279024 16/93 (17%)
IG_FLMN 2285..2375 CDD:214720 16/93 (17%)
Filamin 2372..2459 CDD:279024 4/5 (80%)
IG_FLMN 2376..2465 CDD:214720 1/1 (100%)
IG_FLMN 2474..2561 CDD:214720
Filamin 2474..2555 CDD:279024
IG_FLMN 2657..2751 CDD:214720
Filamin 2657..2745 CDD:279024
Filamin 2755..2840 CDD:279024
IG_FLMN 2756..2847 CDD:214720
Filamin 2847..2937 CDD:279024
IG_FLMN 2850..2944 CDD:214720
DysNP_001036722.1 CH 13..111 CDD:278723 42/100 (42%)
CH 129..225 CDD:278723 24/102 (24%)
SPEC 312..525 CDD:238103 42/249 (17%)
SbcC <325..957 CDD:223496 125/742 (17%)
Smc <816..1591 CDD:224117 153/911 (17%)
SPEC 1174..1365 CDD:238103 30/216 (14%)
SPEC 1289..1485 CDD:295325 31/210 (15%)
SPEC 2369..2576 CDD:238103
SPEC 2477..2714 CDD:238103
WW 2852..2882 CDD:238122
EF-hand_2 2883..2997 CDD:286194
EF-hand_3 3001..3100 CDD:286195
ZZ_dystrophin 3110..3158 CDD:239074
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45439921
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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