DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment jbug and kst

DIOPT Version :10

Sequence 1:NP_001261140.1 Gene:jbug / 43997 FlyBaseID:FBgn0028371 Length:2990 Species:Drosophila melanogaster
Sequence 2:NP_001097492.2 Gene:kst / 38418 FlyBaseID:FBgn0004167 Length:4337 Species:Drosophila melanogaster


Alignment Length:1656 Identity:316/1656 - (19%)
Similarity:545/1656 - (32%) Gaps:542/1656 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 VEIQANTFRNWVNEHLRETGMQVHDWATDFCDGTCLCALVENLQTRPL-KPSWNRRPANQHHYLE 121
            :.||..||..|:|..|.:..|:|.|..||..||..|..|:|.:.:..| ||:..|.   :.|.:|
  Fly    74 LHIQKKTFTKWMNSFLIKAKMEVEDLFTDLADGIKLLKLLEIISSEKLGKPNSGRM---RVHKIE 135

  Fly   122 NATTALKSIEADHIKLVNIGNVDIVNGNIKLILGLIWSLIVRYQI------------GRSKFPPR 174
            |...:|..:.. .::|.:||..|||:||.:|||||||::|:|:||            ...|...:
  Fly   136 NVNKSLAFLHT-KVRLESIGAEDIVDGNPRLILGLIWTIILRFQIQEIEIDVDEENESSEKRSAK 199

  Fly   175 KLMLAWLQA---ALPDCRITNLTTDWNSGVNLAALLDYCQPGLFPHWRSLDPSQS-VRNCTQAMD 235
            ..:|.|.|.   ..|...||:.|..|.||:...||:...:|.||.:...::...| :.|...|.|
  Fly   200 DALLLWCQRKTHGYPGVNITDFTNSWRSGLGFNALIHSHRPDLFEYSTIVNSKNSNLDNLNHAFD 264

  Fly   236 LAQREFGVPKVLEPEYLASPWLDELSGMTYLSYFMKPGGPGYNATMRWVNTQ------------- 287
            .|..|.|:|.:|:.|.:.|...||.|.:||::.:       |:...|..|.|             
  Fly   265 TAANELGIPSLLDAEDIDSARPDEKSILTYVASY-------YHTFARMKNEQKSGKRIANIVGQL 322

  Fly   288 -----VKDPVKNFTTD---W-------NDGRVMCEIIKGLGGSAPAPEKLST--DPFHYE----- 330
                 .|...:..||:   |       .:.|.:...::|:.....|.::..|  .|..|:     
  Fly   323 MDADRKKMQYEGLTTNLLSWIRQKTLELEQRDLPNSLEGIQRELLAFKEYRTIEKPPKYKERSEI 387

  Fly   331 -------NNIRKAVDAGARLGVQPILTAKD--MANPEVEHLGIMAYAAHLQWVPPRPPL------ 380
                   |.:.||::       ||....:|  :.|...:...|:.||.|.:.|..|..|      
  Fly   388 EALYFTINTLLKALN-------QPPYNPQDGQLVNDIEKAWQILEYAEHHREVALRDELLRQEKL 445

  Fly   381 ----------SDLVSVYLESTSGRVGEPTHFR-ID-------VMSRDISLSSVRCHVVPPSGQPG 427
                      |.|...||:.....:.:|.:.| :|       .:|.||.....|.:.:....:  
  Fly   446 EQLNYKFEKKSVLREGYLKEMIQVLSDPRYLRQVDATLKKHEAISADILARVERFNDLTAMAE-- 508

  Fly   428 QPVRLNAHGEGVFVPERYGMHE--------IVVEIGEDS-LGGHFFRALPRLL------------ 471
            :..|.|.||:     ||....|        .::|:.|:. |.......|..||            
  Fly   509 ELDRENYHGK-----ERVRRREQEVMAKWRQLLELLENQRLNLSQMSNLMNLLREIASTTEAVRE 568

  Fly   472 ---QVAPPGMAPCALG--------SLVEVLVNATG--------------APKTEDILVTAVSPTG 511
               |.|...:.|..||        ||.|:.||..|              :.:.:|..:.|..   
  Fly   569 LQQQFASEDVGPHLLGVEELLQAHSLQELQVNTYGETLKRFNRQALPYKSSEHKDAALLAQR--- 630

  Fly   512 ISHNCPLKKIDEGHSAIFKPDEAGIWEIAITYQGRHIQGGPFTCAVFD-------------ASGV 563
                  |..::|.:|.:.:...|....:.......|....      :|             .:|:
  Fly   631 ------LADLEEAYSELLRRSAARRARLEEARNFHHFMED------YDNEESWLVDKQRICKTGI 683

  Fly   564 SVHGLDGAMPL----RAHTFEVDAR-----GVGVSGELHVDIVHDKHSLVCS-----------VE 608
            :...|...:.|    :|...|:.:|     .:..:|:..:...|.:.|.:.|           :|
  Fly   684 TAKDLRAVLSLQQKHKALEDEIKSRKPKSGQMSTAGKRLIGEQHPRSSEIQSRIDSLAEHWQALE 748

  Fly   609 KIVENKYRVTFMPRQNGKYRVYIYFNGYDVKGSPFIMRVGTKGRSGKTRSSPLHDSKHRSESPSM 673
            .:||.:.|     :.......|.::.                             ..:.:||...
  Fly   749 ALVELRRR-----QLEDAAEAYQFYT-----------------------------DANEAESWLN 779

  Fly   674 HFVSTTNTRHNDYRNSS------LSRHNTAE-RTNSYSPQYSPKLDTTDYHSSSSRYYKRE--SE 729
            ..::..|:|  ||.|..      |.||...: ..|:||.      |..:.:..:.:..|..  :.
  Fly   780 EKIALVNSR--DYGNDEPSAQALLQRHRDLQGELNAYSG------DILNLNQQADKLIKAGICTL 836

  Fly   730 ENHATPPPAPPPASGSPTVKYLNSA---------DLYTETLNGRRDSKTSN-------------- 771
            |..|..|..|....    .:::|..         |.:.|.|..::.::|..              
  Fly   837 ELSAAEPELPEVEQ----EEWVNETRLVPKEVWEDEWVEKLEHKKVTETKMLPHVKSLFPFEGQG 897

  Fly   772 -----------SSSTKNDYY-YDKEN--ELYSQRRAVTKPKLTP-----PREERELTSTTNTSSS 817
                       .|.|.:|:: ..|:|  |.:.....|.:.:..|     |:.|:           
  Fly   898 MKMDKGEVMLLKSKTNDDWWCVRKDNGVEGFVPANYVREVEPRPVACIVPKAEK----------- 951

  Fly   818 SSFQQRHQQLATSTLTRSLSPI---------PSPTLNTRSSEVHTHSPLTIKTSNQYESSTRNIT 873
               .:..|::..:.|.|.:.|:         |.|.:..|:|....:     :.::..|...:.|.
  Fly   952 ---VKSLQKVKKTILVRQVVPVKRIKPVSVAPKPLVQRRTSTQSIN-----ENADSVEKRQQRIN 1008

  Fly   874 SSPRHASVSPVQRYSPNSAYITTATHRMGSPLTSPVSKNGYESSRTVEKSSTYKSTSN------- 931
            .:.........:|:    |.:..:.|..|........:...:....:.||...:...|       
  Fly  1009 QTYDELQEMAQKRH----ALLEDSIHLFGFYRECDDFEKWMKEKERMIKSDEGEGVDNAKRKFEK 1069

  Fly   932 YVTDSNIRAS--PSLYGTAERLRRTGSPE---------------PRIDHSSNVRVSSMKPASARR 979
            ::||.:..:.  ..:.|..:..||.|..:               .|::::...|..|::.||   
  Fly  1070 FITDLSAASKRVEEIDGAVDTFRRQGHSQLDKIIARQRQIHQIWQRLNNAKAQREKSLEGAS--- 1131

  Fly   980 DSWDVINKTKHMLSHNSLESLANMTEKQLNTELQYNRPDLDHETHRNTQYNKFALHKQQQQQSDY 1044
             |.::.|:|..       |:...|:||.|..:.....|||     |..|    ||  |::.|:..
  Fly  1132 -SVELFNRTCD-------EAKVWMSEKMLQLDTAVITPDL-----RTVQ----AL--QRRHQNLE 1177

  Fly  1045 RRDSPDDGERYKPSAITVKSHS-NNTYTDKSGGYTKTVKESSEHVVTESNGHGPSPGYGYSSLSR 1108
            |..:|.:.   |.:.:|...:| .|.|                                      
  Fly  1178 RELAPVED---KVNRVTYLGNSVKNAY-------------------------------------- 1201

  Fly  1109 FRPIDGNATGARAIRVQDI-----PNGS-IGRPVEFEIDGSRAGSGNLEILV------------- 1154
              |.:.:...||...|||:     ..|| :...:|.|: |.:..:.:.::|:             
  Fly  1202 --PAEKDNVNARQQEVQDMWQQVQQRGSDLRNRIESEV-GQQVFNNSAKVLLAWIDSVKDQLNAD 1263

  Fly  1155 NGGRVTSSVRSLGGQRFIASFTPHEHGTHTVQITFNGETV-PGSPWHAEIMSSPGLTALGESTRL 1218
            ...|...:..:|..:..........|.|..|::...|:.: .|.|..||                
  Fly  1264 ESARDVETANNLLKKHNDLGDDIRAHDTEFVEVIQLGKQLSDGKPNMAE---------------- 1312

  Fly  1219 VPANTPAVFEILPPPGQSLSKG---------ECV-ATVLTPSKSKLNARV-THEA----ANGAAR 1268
                |.||.|.|.....::.:|         :|| ..:......|::|.. :|||    .|..|.
  Fly  1313 ----TVAVIERLKAEQDAIHRGWAEKQKWLLQCVDLQMFNREADKIDATTKSHEAFLEYNNLGAS 1373

  Fly  1269 IEFVPTEVGTHV--------IDASINGTKIAGGPLIAK-VYDSSLI-----QVTEVNGGVVGQAC 1319
            ::.|...:..|:        .|..:.|.......||:. .|||..|     ||......|..:|.
  Fly  1374 LDEVEAILKRHLDFEKSLMAQDKILKGFSDNADKLISNDHYDSKYIGDRRNQVLGKRKAVKDRAF 1438

  Fly  1320 Q-------------FRVDAS-----------AAGEG------------------QLEISINEGEV 1342
            :             |..:|.           .||:.                  :.|:..|||::
  Fly  1439 ERKRLLQASKDFHKFAAEADDLKVWLQDKTRIAGDENYRDLSNLPRKLQKHQAFERELRANEGQL 1503

  Fly  1343 PNHVQVVGGGRCLV---SFTPEQAKSHLIDI 1370
            .|   |...|:.||   :..|| .:|.:.|:
  Fly  1504 RN---VTKDGQALVQAGNRVPE-VESRVADL 1530

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
jbugNP_001261140.1 CH_jitterbug-like_rpt1 57..166 CDD:409076 42/108 (39%)
CH_jitterbug-like_rpt2 170..274 CDD:409078 32/107 (30%)
CH_jitterbug-like_rpt3 275..373 CDD:409034 25/141 (18%)
IG_FLMN 468..560 CDD:214720 21/141 (15%)
IG_FLMN 560..648 CDD:214720 15/107 (14%)
IG_FLMN 1119..1198 CDD:214720 18/98 (18%)
IG_FLMN 1220..1302 CDD:214720 22/105 (21%)
IG_FLMN 1310..1389 CDD:214720 19/106 (18%)
IG_FLMN 1399..1480 CDD:214720
IG_FLMN 1480..1569 CDD:214720
IG_FLMN 1575..1659 CDD:214720
IG_FLMN 1661..1747 CDD:214720
IG_FLMN 1757..1837 CDD:214720
IG_FLMN 1837..1926 CDD:214720
IG_FLMN 1936..2023 CDD:214720
Filamin 2021..2111 CDD:395505
IG_FLMN 2198..2280 CDD:214720
IG_FLMN 2285..2375 CDD:214720
IG_FLMN 2376..2465 CDD:214720
Filamin 2474..2555 CDD:395505
IG_FLMN 2657..2751 CDD:214720
IG_FLMN 2756..2847 CDD:214720
IG_FLMN 2850..2944 CDD:214720
kstNP_001097492.2 CH_beta_spectrin_rpt1 61..176 CDD:409042 41/105 (39%)
CH_beta_spectrin_rpt2 196..302 CDD:409043 32/112 (29%)
SPEC 450..640 CDD:238103 39/205 (19%)
SPEC 658..832 CDD:238103 32/221 (14%)
SH3 885..935 CDD:214620 6/49 (12%)
SPEC 1030..1236 CDD:238103 49/270 (18%)
SPEC 1134..1341 CDD:238103 51/288 (18%)
SPEC 1343..1551 CDD:238103 38/192 (20%)
SPEC 1449..1658 CDD:238103 17/86 (20%)
SPEC 1555..1764 CDD:238103
SPEC 1765..1975 CDD:238103
SPEC 1873..2080 CDD:238103
SPEC 1979..2185 CDD:238103
SPEC 2188..2402 CDD:238103
SPEC 2407..2618 CDD:238103
SPEC 2514..2725 CDD:238103
SPEC 2726..2934 CDD:238103
SPEC 2935..3145 CDD:238103
SPEC 3042..3251 CDD:238103
SPEC 3149..3357 CDD:238103
SPEC 3359..3567 CDD:238103
SPEC 3465..3680 CDD:238103
PH_beta_spectrin 3801..3904 CDD:269975
Blue background indicates that the domain is not in the aligned region.

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