DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jbug and beta-Spec

DIOPT Version :9

Sequence 1:	NP_001261140.1	Gene:	jbug / 43997	FlyBaseID:	FBgn0028371	Length:	2990	Species:	Drosophila melanogaster
Sequence 2:	NP_001259660.1	Gene:	beta-Spec / 32746	FlyBaseID:	FBgn0250788	Length:	2308	Species:	Drosophila melanogaster

Alignment Length:	265	Identity:	81/265 - (30%)
Similarity:	123/265 - (46%)	Gaps:	32/265 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 IQANTFRNWVNEHLRETGMQVHDWATDFCDGTCLCALVENLQTRPL-KPSWNRRPANQHHYLENA 123
            :|..||..|||.||.....::.|...|..||..|..|:|.|....| ||:..:.   :.|.|||.
  Fly    51 VQKKTFTKWVNSHLCRVNCRIADLYVDMRDGKHLIKLLEVLSGERLPKPTKGKM---RIHCLENV 112

  Fly   124 TTALKSIEADHIKLVNIGNVDIVNGNIKLILGLIWSLIVRYQI---------GRSKFPPRKLMLA 179
            ..||:.:....:.|.|||:.|||:||..|.|||||::|:|:||         .:.....:..:|.
  Fly   113 DKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQDITIEEVDNKETKSAKDALLL 177

  Fly   180 WLQ---AALPDCRITNLTTDWNSGVNLAALLDYCQPGLFPHWRSLDPSQSVRNCTQAMDLAQREF 241
            |.|   |...:..:.|.||.|..|:...|::...:|.|. .:..|..:.::.|...|.|:|:.:.
  Fly   178 WCQMKTAGYHNVNVRNFTTSWRDGLAFNAIIHKHRPDLV-QFEKLSKTNAIHNLNNAFDVAEDKL 241

  Fly   242 GVPKVLEPEYLASPWLDELSGMTYL----SYFMK------PG---GPGYNATMRWVNTQVKDPVK 293
            |:.|:|:.|.:.....||.|.:||:    .||.|      .|   |......|.  |.::....:
  Fly   242 GLAKLLDAEDVFVEHPDEKSIITYVVTYYHYFSKLKQETVQGKRIGKVVGIAME--NDKMVHDYE 304

  Fly   294 NFTTD 298
            |||:|
  Fly   305 NFTSD 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jbug	NP_001261140.1	CH	60..165	CDD:237981	42/105 (40%)
		CH	172..269	CDD:278723	26/103 (25%)
		CH	281..371	CDD:278723	6/18 (33%)
		IG_FLMN	468..560	CDD:214720
		Filamin	468..554	CDD:279024
		Filamin	557..644	CDD:279024
		IG_FLMN	560..648	CDD:214720
		Filamin	1116..1200	CDD:279024
		IG_FLMN	1119..1198	CDD:214720
		Filamin	1210..1294	CDD:279024
		Filamin	1299..1383	CDD:279024
		IG_FLMN	1310..1389	CDD:214720
		Filamin	1386..1473	CDD:279024
		IG_FLMN	1399..1480	CDD:214720
		Filamin	1477..1563	CDD:279024
		IG_FLMN	1480..1569	CDD:214720
		Filamin	1570..1653	CDD:279024
		IG_FLMN	1575..1659	CDD:214720
		Filamin	1657..1741	CDD:279024
		IG_FLMN	1661..1747	CDD:214720
		Filamin	1756..1830	CDD:279024
		Filamin	1834..1919	CDD:279024
		IG_FLMN	1837..1926	CDD:214720
		IG_FLMN	1936..2023	CDD:214720
		Filamin	1941..2017	CDD:279024
		Filamin	2021..2111	CDD:279024
		IG_FLMN	2025..2114	CDD:214720
		Filamin	2187..2268	CDD:279024
		Filamin	2279..2369	CDD:279024
		IG_FLMN	2285..2375	CDD:214720
		Filamin	2372..2459	CDD:279024
		IG_FLMN	2376..2465	CDD:214720
		IG_FLMN	2474..2561	CDD:214720
		Filamin	2474..2555	CDD:279024
		IG_FLMN	2657..2751	CDD:214720
		Filamin	2657..2745	CDD:279024
		Filamin	2755..2840	CDD:279024
		IG_FLMN	2756..2847	CDD:214720
		Filamin	2847..2937	CDD:279024
		IG_FLMN	2850..2944	CDD:214720
beta-Spec	NP_001259660.1	CH	51..149	CDD:278723	40/100 (40%)
		CH	170..269	CDD:278723	26/99 (26%)
		Spectrin	298..408	CDD:278843	4/12 (33%)
		SPEC	422..521	CDD:197544
		SPEC	525..740	CDD:238103
		SPEC	639..846	CDD:238103
		SPEC	848..1058	CDD:238103
		SPEC	955..1169	CDD:238103
		SPEC	1170..1380	CDD:238103
		SPEC	1386..1484	CDD:197544
		SPEC	1488..1699	CDD:238103
		SPEC	1594..1806	CDD:238103
		SPEC	1807..2015	CDD:238103
		Spectrin	2018..>2078	CDD:278843
		PH	2167..2275	CDD:278594
		PH_beta_spectrin	2167..2274	CDD:269975
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439906
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840