DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jbug and GAS2L2

DIOPT Version :9

Sequence 1:	NP_001261140.1	Gene:	jbug / 43997	FlyBaseID:	FBgn0028371	Length:	2990	Species:	Drosophila melanogaster
Sequence 2:	NP_644814.1	Gene:	GAS2L2 / 246176	HGNCID:	24846	Length:	880	Species:	Homo sapiens

Alignment Length:	746	Identity:	151/746 - (20%)
Similarity:	232/746 - (31%)	Gaps:	285/746 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   606 SVEKIVENKYRVTFMPRQNGKYRVYIYFNGYDVKGSPFIMRVG----TKGRSGKTRSSPLHDSKH 666
            |:.|:.|.||||       |.....|:..   :..:..::|||    |.|
Human   224 SMVKVSEGKYRV-------GDSNTLIFIR---ILRNHVMVRVGGGWDTLG--------------- 263

  Fly   667 RSESPSMHFVSTTNTRHNDYRNSSLSRHNTAERTNSYSPQYSPKLDTTDYHSSSSRYYKRESEEN 731
                   |::.    :|:..|.:|||                        |...| :.|
Human   264 -------HYLD----KHDPCRCTSLS------------------------HKPGS-FLK------ 286

  Fly   732 HATPPPAPP----------PASGSPTVKYLNSADLYTETLNGRRDSKTSNSSSTKNDYYYDKENE 786
                |||||          |:...||:....|     ::.....|.||..||.
Human   287 ----PPAPPVQHEVRVQDGPSQTQPTMTISRS-----QSPPPPVDWKTYTSSD------------ 330

  Fly   787 LYSQRRAVTKPKLTPPREERELTSTTNTSSSSSFQQRHQQLATSTLTRSLSPIPS---PTLNTRS 848
                 |.:..|..:.||..||..:.|..|...:...|.|:       |||  |||   ||..
Human   331 -----RRLRPPTPSSPRPRRERGAGTGASREMAPFLRCQE-------RSL--IPSWRQPTAG--- 378

  Fly   849 SEVHTHSPLTIKTSNQYESSTRNITSSPRHASVSPVQRYSPN-------SAYITTATHRMGSPLT 906
                 .||.:.::|:..:......|||.:..     :||.|.       ::::...|...|:...
Human   379 -----DSPPSPQSSSTQKGRDPQCTSSGKRE-----ERYPPELPRGRIPTSWVHEETDSWGTDAG 433

  Fly   907 SPVSKNGYESSRTVEKSSTYKSTSNYVTDSNIRASPSLYGTAERLRRTGSPEPRIDHSSNVRVSS 971
            :|          |.::....::|:..::.......|..:|.||.|   |...|..|.:.......
Human   434 NP----------TPQRLRAIEATTKGISARGPSPLPRSFGPAECL---GLRLPLRDEAKGAFFQF 485

  Fly   972 MKPASARRDSWDVINKTKHML------SHNSLESLANMTEKQLNTELQYN-------RPDLDHET 1023
            .:|.|.|..: .|...||..:      ......|....|.....|||..:       ..||...|
Human   486 REPESVRSPT-PVQGLTKIPIRLPPARPPTPGRSFPGATSGSPRTELGRDPIPLRAVTVDLAGST 549

  Fly  1024 HRNTQYNKFALHKQQQQQSDYR-----RDSPDDGERYKPSAITVKSHSNNTYTDKSGGYTKTVKE 1083
            |.:.....    :|:.||.|.:     |:|.|.|                 ..::.|.||..
Human   550 HGDCSVEV----RQEDQQLDIQVMAEARESWDLG-----------------LQEQEGRYTPL--- 590

  Fly  1084 SSEHVVTESNGHGPSPGYGYSSLSRFRPIDGNATGARAIRVQDIPNGSIGRPVEFEIDGSRAGSG 1148
                                       |:.||...|            |...:|.||      .|
Human   591 ---------------------------PLGGNKEQA------------IYCSLEEEI------LG 610

  Fly  1149 NLEILVNGGRVTSSVRSLGGQRFIASFTPHEHGTHTVQITFNGETV---------PGSPWHAEI- 1203
            |:::|        .|||...|           ||.:..|..:|..:         ||.|:...|
Human   611 NMKLL--------EVRSACPQ-----------GTRSGVIPRSGVYIPRLAGQWPEPGGPYDKAIQ 656

  Fly  1204 ---MSSPGLTALG-ESTRLVPANTPAVFEILPPPGQSLSKGECVATVLTP-SKSKLNARVTHEAA 1263
               ..||.|..:. |:.:..|..:|.. .:.|.|| || ||:..|....| :|:.|:|:.||
Human   657 ELAQGSPSLLKVDLEAWKAAPTGSPKP-AVTPGPG-SL-KGKLGARQSGPRTKASLSAKGTH--- 715

  Fly  1264 NGAARIEFVPTEVGTHVIDASINGTKIAGGP 1294
                 :..||.:.|.....::::.:..|..|
Human   716 -----MRKVPPQGGQDCSASTVSASPEAPTP 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jbug	NP_001261140.1	CH	60..165	CDD:237981
		CH	172..269	CDD:278723
		CH	281..371	CDD:278723
		IG_FLMN	468..560	CDD:214720
		Filamin	468..554	CDD:279024
		Filamin	557..644	CDD:279024	9/37 (24%)
		IG_FLMN	560..648	CDD:214720	10/41 (24%)
		Filamin	1116..1200	CDD:279024	19/92 (21%)
		IG_FLMN	1119..1198	CDD:214720	18/87 (21%)
		Filamin	1210..1294	CDD:279024	21/85 (25%)
		Filamin	1299..1383	CDD:279024
		IG_FLMN	1310..1389	CDD:214720
		Filamin	1386..1473	CDD:279024
		IG_FLMN	1399..1480	CDD:214720
		Filamin	1477..1563	CDD:279024
		IG_FLMN	1480..1569	CDD:214720
		Filamin	1570..1653	CDD:279024
		IG_FLMN	1575..1659	CDD:214720
		Filamin	1657..1741	CDD:279024
		IG_FLMN	1661..1747	CDD:214720
		Filamin	1756..1830	CDD:279024
		Filamin	1834..1919	CDD:279024
		IG_FLMN	1837..1926	CDD:214720
		IG_FLMN	1936..2023	CDD:214720
		Filamin	1941..2017	CDD:279024
		Filamin	2021..2111	CDD:279024
		IG_FLMN	2025..2114	CDD:214720
		Filamin	2187..2268	CDD:279024
		Filamin	2279..2369	CDD:279024
		IG_FLMN	2285..2375	CDD:214720
		Filamin	2372..2459	CDD:279024
		IG_FLMN	2376..2465	CDD:214720
		IG_FLMN	2474..2561	CDD:214720
		Filamin	2474..2555	CDD:279024
		IG_FLMN	2657..2751	CDD:214720
		Filamin	2657..2745	CDD:279024
		Filamin	2755..2840	CDD:279024
		IG_FLMN	2756..2847	CDD:214720
		Filamin	2847..2937	CDD:279024
		IG_FLMN	2850..2944	CDD:214720
GAS2L2	NP_644814.1	CH	34..159	CDD:237981
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	180..200
		GAS2	207..274	CDD:280367	16/85 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	283..360		24/109 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..437		14/87 (16%)
		Interaction with ADORA2A. /evidence=ECO:0000250\|UniProtKB:Q5SSG4	438..880		83/407 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	489..533		10/44 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..880		21/77 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140854
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930