DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jbug and Gas2l2

DIOPT Version :9

Sequence 1:	NP_001261140.1	Gene:	jbug / 43997	FlyBaseID:	FBgn0028371	Length:	2990	Species:	Drosophila melanogaster
Sequence 2:	NP_001013781.1	Gene:	Gas2l2 / 237891	MGIID:	3652048	Length:	860	Species:	Mus musculus

Alignment Length:	1247	Identity:	231/1247 - (18%)
Similarity:	364/1247 - (29%)	Gaps:	500/1247 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 PGLFPHWRSLDPSQSVRNCTQAM--DLAQREFGVPKVLEPEYLASPWLDELSGMTYLSYFMKPGG 274
            ||  |..||:.|.:|.....:||  |||:                 ||.:|.|:..
Mouse    14 PG--PPVRSIRPFKSSEQYLEAMKEDLAE-----------------WLRDLYGLDI--------- 50

  Fly   275 PGYNATMRWVNTQVKDPVKNFTTDWNDGRVMCEIIK-----GLGGSAPAPEKLSTDP-------- 326
                            ...||......|.|:|....     .|...|.|||:....|
Mouse    51 ----------------DADNFLRVLETGLVLCRHANTVTEAALAFLAEAPERAQKIPMPQAGVFC 99

  Fly   327 --------FHYENNIRKAVD-AGARLGVQPILTAKDMANPEVEHLGIMAYAAHLQWVPPRPPLSD 382
                    |...:||...:. ....:|:|.:|..      |.|.|.:            |..:..
Mouse   100 NGAAQPGTFQARDNISNFIQWCRKEMGIQEVLMF------ETEDLVL------------RKNVKS 146

  Fly   383 LVSVYLESTSGR------VGEP--THFRIDV---MSRDISLSSVRCHVVPPSGQPGQPVRLNAHG 436
            :|...||  .||      |..|  .|...::   :.||::|         ||..|..|:
Mouse   147 VVLCLLE--LGRRAWRFGVAAPALVHLEEEIDEELRRDLAL---------PSPDPPPPI------ 194

  Fly   437 EGVFVPERYGMHEIVVEIGEDSLGGHFFRALPRLLQVAPPGMAPCALGSLVEVLVNATGAPKTED 501
                                                  ||...||...:|              |
Mouse   195 --------------------------------------PPARRPCHFHNL--------------D 207

  Fly   502 ILVTAVSPTGISH-NCPLK----KIDEGHSAIFKPDEAGIWEIAITYQGRHIQGGPFTCAVFDAS 561
            .:|.::    :|| .||::    ||.||...:...:......|..::....:.||      :|..
Mouse   208 QMVQSL----VSHCTCPVQFSMVKISEGKYRVGDSNTLIFIRILRSHVMVRVGGG------WDTL 262

  Fly   562 GVSVHGLDGAMPLRAHTFEVDARGVGVSGELHVDIVHDKHSLVCSVEKIVENKYRVTFMPRQNGK 626
            |   |.||...|.|.                 ..:.|...|.:......|:::.:|...|.|
Mouse   263 G---HYLDKHDPCRC-----------------TSLSHKPGSFLKPPGPPVQHEVKVQDGPSQ--- 304

  Fly   627 YRVYIYFNGYDVKGSPFIMRVGTKGRSGKTRSSPL----------HDSKHRSESPSMHFVST--- 678
                         ..|.:    |..||    .|||          ...|.|..:||...:.:
Mouse   305 -------------PQPTM----TISRS----QSPLPPVDWKTYTSSSRKLRPPTPSSPGLRSEPP 348

  Fly   679 --TNTRHNDYRNSSLSRHNTAERTNSYSPQYSPKLDTTDYHSSSSRYYKRESEENHATPPPAPPP 741
              ..|...|....|..:...::|.:|..||:|......|..|:.|.  ||      |...|..||
Mouse   349 VRARTLREDPLPRSQEKPTPSQRMSSPGPQFSSTCRGPDLQSTLSG--KR------ANRCPGEPP 405

  Fly   742 ASGSPTVKYLNSADLYTETLNGRRDSKTSNSSSTKNDYYYDKENELYSQRRAVTKPKLTPPREER 806
            ...:||        |:.....|.|.:.|                      :|.|..:|..|
Mouse   406 RGRTPT--------LWVHKEAGSRGTHT----------------------KAPTPQRLQIP---- 436

  Fly   807 ELTSTTNTSSSSSFQQRHQQLATSTLTRSLSPIPSPTLNTRSSEVHTHSPLTIKTSNQYESSTRN 871
            |.||...::...|...|...||:..:...|....||.|:         .|:|:.:|    |..:.
Mouse   437 EATSKRTSARGPSPPPRSSSLASPHMIWVLHQGASPQLS---------EPMTVHSS----SPGKG 488

  Fly   872 ITSSPRHASVSPVQRYSPNSAYITTATHRMGSPLTSPVSKNGYESSRTVEKSSTYKSTSNYVTDS 936
            :|..|  ..:||.:..:|..:.:.|.    |...|.    .|..|||.:| .:..:||..:   .
Mouse   489 LTKIP--IRLSPARPPTPGRSSLGTE----GEYSTG----RGSISSRALE-GNLDRSTHGH---H 539

  Fly   937 NIRASPSLYGTAERLRRTGSPEPRIDHSSNVRVSS--MKPASARRDSWD------VINKTKHMLS 993
            ::.||.                   ||.::::.:|  ..|.|.....|.      .:.:.:....
Mouse   540 SVEASG-------------------DHQTDIQTTSETEDPRSLGTQKWKERHTSLALGRRREQAL 585

  Fly   994 HNSL--ESLANMTEKQLNTELQYNRPDLDHETHRNTQYNKFALHKQQQQQSDYRRDSPDDGERYK 1056
            :::|  |.:|||  |.|.....|.                         |....:..|..|. |.
Mouse   586 YDNLKEEVVANM--KLLEVGTAYT-------------------------QGTRSQAIPRSGV-YV 622

  Fly  1057 PSAITVKSHSNNTYTDKSGGYTKTVKESSEHVVTESNGHGPSPGYGYSSLSRFRPIDGNATGARA 1121
            ||.       ...:.:..|.|.|.::|..:         ||.|         ...:|
Mouse   623 PSL-------GGRWPEPGGPYDKVIRELVQ---------GPPP---------LLKVD-------- 654

  Fly  1122 IRVQDIPNGSIGRPVEFEIDGSRAGSGNLEILVNGGRVTSSVRSLGGQRFIASFTPHEHGTHTVQ 1186
            ::...:.:..:.||:   :|   .||...::   |.|.|       |.|..||....:....||
Mouse   655 LKAWKVGSECLPRPI---VD---PGSPKEKL---GSRET-------GTRIKASLNAEDTTVRTV- 702

  Fly  1187 ITFNGETVPGSPWHAEIMSSPGLTA--------------------LGESTRLV--PANTPAVFEI 1229
                      ||...:..|:|.::|                    ||:..|.:  |...|:::::
Mouse   703 ----------SPARGQGCSTPPVSANLEAPTRSCSDPSSDKASVCLGKGKRTLRKPQKIPSIYKL 757

  Fly  1230 LPPPGQSLSKGECVATVLTPSKSKLNARVTHEAANGAARIEFVPTEVGTHVIDASINGTKIAGGP 1294
            ...|                   ::..|..|......:||. .|......|:..:..|:::....
Mouse   758 KLRP-------------------RIRPRRDHRPEKRPSRIP-KPLPYSCLVLARTAPGSRLLKAT 802

  Fly  1295 LIAKVYDSSLIQVTEVNGGVVGQACQFRVDASAAGEGQ---------LEISINEGEVPNHVQVVG 1350
            |                ||..|..||  |:.:...|.:         ||.||...|....:::
Mouse   803 L----------------GGKGGVPCQ--VNGTGKKEEEKKKGGSNISLESSIQPAESQEPLKL-- 847

  Fly  1351 GGRCLVSFTPEQ 1362
            ||..|   :||:
Mouse   848 GGTPL---SPEE 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jbug	NP_001261140.1	CH	60..165	CDD:237981
		CH	172..269	CDD:278723	16/58 (28%)
		CH	281..371	CDD:278723	20/111 (18%)
		IG_FLMN	468..560	CDD:214720	18/96 (19%)
		Filamin	468..554	CDD:279024	18/90 (20%)
		Filamin	557..644	CDD:279024	14/86 (16%)
		IG_FLMN	560..648	CDD:214720	13/87 (15%)
		Filamin	1116..1200	CDD:279024	16/83 (19%)
		IG_FLMN	1119..1198	CDD:214720	14/78 (18%)
		Filamin	1210..1294	CDD:279024	14/105 (13%)
		Filamin	1299..1383	CDD:279024	17/73 (23%)
		IG_FLMN	1310..1389	CDD:214720	17/62 (27%)
		Filamin	1386..1473	CDD:279024
		IG_FLMN	1399..1480	CDD:214720
		Filamin	1477..1563	CDD:279024
		IG_FLMN	1480..1569	CDD:214720
		Filamin	1570..1653	CDD:279024
		IG_FLMN	1575..1659	CDD:214720
		Filamin	1657..1741	CDD:279024
		IG_FLMN	1661..1747	CDD:214720
		Filamin	1756..1830	CDD:279024
		Filamin	1834..1919	CDD:279024
		IG_FLMN	1837..1926	CDD:214720
		IG_FLMN	1936..2023	CDD:214720
		Filamin	1941..2017	CDD:279024
		Filamin	2021..2111	CDD:279024
		IG_FLMN	2025..2114	CDD:214720
		Filamin	2187..2268	CDD:279024
		Filamin	2279..2369	CDD:279024
		IG_FLMN	2285..2375	CDD:214720
		Filamin	2372..2459	CDD:279024
		IG_FLMN	2376..2465	CDD:214720
		IG_FLMN	2474..2561	CDD:214720
		Filamin	2474..2555	CDD:279024
		IG_FLMN	2657..2751	CDD:214720
		Filamin	2657..2745	CDD:279024
		Filamin	2755..2840	CDD:279024
		IG_FLMN	2756..2847	CDD:214720
		Filamin	2847..2937	CDD:279024
		IG_FLMN	2850..2944	CDD:214720
Gas2l2	NP_001013781.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		5/9 (56%)
		CH	34..159	CDD:237981	34/186 (18%)
		GAS2	207..274	CDD:280367	19/79 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..459		49/243 (20%)
		Interaction with ADORA2A and GNAS. /evidence=ECO:0000269\|PubMed:23994616	431..860		112/607 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	473..574		28/146 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..743		9/56 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..781		5/42 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..860		18/79 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830817
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930