Sequence 1: | NP_001261140.1 | Gene: | jbug / 43997 | FlyBaseID: | FBgn0028371 | Length: | 2990 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_001449.3 | Gene: | FLNC / 2318 | HGNCID: | 3756 | Length: | 2725 | Species: | Homo sapiens |
Alignment Length: | 3263 | Identity: | 722/3263 - (22%) |
---|---|---|---|
Similarity: | 1118/3263 - (34%) | Gaps: | 950/3263 - (29%) |
- Green bases have known domain annotations that are detailed below.
Fly 57 WVEIQANTFRNWVNEHLRETGMQVHDWATDFCDGTCLCALVENLQTRPLKPSWNRRPANQHHYLE 121
Fly 122 NATTALKSIEADHIKLVNIGNVDIVNGNIKLILGLIWSLIVRYQIG-----------RSKFPPRK 175
Fly 176 LMLAWLQAALPDCRITNLTTDWNSGVNLAALLDYCQPGLFPHWRSLDPSQSVRNCTQAMDLAQRE 240
Fly 241 FGVPKVLEPEYLASPWLDELSGMTYLSYF----MKPGGPGYNATMRWVNTQVKDPVKNFTTDWND 301
Fly 302 GRVMCEIIKGLGGSAPAPEKLSTDPFHYENNIRKAVDAGARLGVQPILTAKDMANPEVEHLGIMA 366
Fly 367 YAAHLQWVPPRPPLSDLVSVYLESTSGRVGEPTHFRIDVMSRDISLSSVRCHVVPPSGQPGQPVR 431
Fly 432 LNAHGEGV---------------FVPERYGMHEIVVEIGEDSLGGHFFRALPRLLQVAPPGMA-- 479
Fly 480 ----PCALGSLVEVLVNATGAPK----------TEDILVTAVSPTGISHNCPLKKIDEGHSAI-- 528
Fly 529 -FKPDEAGIWEIAITYQGRHIQGGPFTCAVFDASG-----VSVHGLD--GAMPLRAHTFEVDARG 585
Fly 586 VGVSGELHVDIVHDKHS-LVCSVEKIVENKYRVTFMPRQNGKYRVYIYFNGYDVKGSPFIMRVGT 649
Fly 650 KGRSGKTRS-SPLHDSKHRSESPSMHFVSTTNTRHNDYRNSSLSRHNTAERTNSYS---PQYSPK 710
Fly 711 LDTTDYHSSSS--RYYKRE----------SEENHATPP------PAPPPASGSPTVKYLNSADLY 757
Fly 758 TETLNGRRDSKTSNSSSTKNDYYYDKENELYSQRRAVTKPKLTPPREERELTSTTNTSSSSSFQQ 822
Fly 823 RHQQLATSTLTRSLSPIPSPTLNTRSSEVHTHSPLTIKTSNQYESSTRNITSSPRHASVSP---- 883
Fly 884 --VQRYSPNSAYITTATHRMGSPLTSPVSKNGYESSR----TVEKSSTYKSTSNYVTDSNIRASP 942
Fly 943 SLYGTAERLRRTGSPEPRIDHSSNVRVSSMKPASARRDSWDVINKTKHMLSHNSLESLANMTEKQ 1007
Fly 1008 LNTELQYNRPDLDHETHRNTQYNKFALHKQQQQQSDYRRDSPDDGERYKPSAITVKSHSNNTYTD 1072
Fly 1073 K-----SGGYTKTVKESSEHVVTESNGHGPSPGYGYSSLSRFRPIDG-NATGARAIRVQDIPNGS 1131
Fly 1132 IGRPVEFEIDGSRAGSGNLEILVNG---GRVTSSVRSLGGQ--RFIASFTPHEHGTHTVQITFNG 1191
Fly 1192 ETVPGSPWHAEI--------MSSPGL---TALGESTRLVPANTPAVFEILPPPGQSLSKGECVAT 1245
Fly 1246 VLTPSKSKLNARVTHEAANGAARIEFVPTEVGTHVIDASINGTKIAGGPLIAK-----------V 1299
Fly 1300 YDSSLIQVTEVNGGVVGQACQFRVDASAAGEGQLEISINEG--EVPNHVQVVGGGRCLVSFTPEQ 1362
Fly 1363 AKSHLIDIKFNGETVRGCPF---VCAVADTSRVLLNLSNLELIPVNRPSSFHITVSGGGAAELAV 1424
Fly 1425 SVRGPQG-ELPVRVTGDIHAGFTAEFTPTTVGGHSINVEYNGFAVQGTP---FLAKSYDASKVVV 1485
Fly 1486 ---GSVSRGTMGRPV--QFTVDAGD-AGEGNLEIT---ISAKGQNIPTQVHPQGSARFSVSFVPT 1541
Fly 1542 ESCEHTINVSFNKMPVPGCPITVSISGGVAGPQVSLGGP----GPVHQTNSFVINHNGGRLEDIE 1602
Fly 1603 VNVEGPAGQSVPAQVHQSADGVFKAEFVPRVVGEHRVNVTVNGLPTAGSPYAAKVYD-VSAIKVK 1666
Fly 1667 NVSSGTVGKAV------TFLVETSQAGPGNLEVTV---NGGRVPTSAQAQGQHTYAISFTPREAE 1722
Fly 1723 SHTVELRFNSQDVPGSPFTCRV-----AAAARIQSPE-TMDKVSVGRLFEFVVES----DTKPTV 1777
Fly 1778 EVLGPARRSVPVKIDALGSSTLGYNVKFEPMEVGDHSVEVRLPGGGHVEGSPFLLKAY---SAEK 1839
Fly 1840 VIVTDIRAG-----------VVNKSVSFGINASQAGAGNLEIIVAV-NGKNVPNFVQSEGNARFK 1892
Fly 1893 VNFKPTEAATHSLSVRFNGHPVPGSPFSCHIAAAAASP--------------------------- 1930
Fly 1931 -------------------SMGLPRAMAMGECLKQAAVKMDNTFELEGFDGVEPQIFVTSPSGDN 1976
Fly 1977 EHCQLSQHDGGSYSASFRPTTVGRHLISVTANDQHINGSPFSCNVFDVSRVSISGLEQQYGP--- 2038
Fly 2039 -ANLGVPVTFSVDAAGAGEGTLELVVSTDSSTVKAEVVAC---ARGLYDVTFVPQSTEPHYVNIT 2099
Fly 2100 FNEVAVDGSPFRV----DIQQHTQHIQIGSLAAIDFPADDQIVEIFSPDQKSVPYSINRQTAEFR 2160
Fly 2161 THMTGNYTLRFIDRETRQHIGSRTLCVFDPTLVKITEVSEAFCHRPASIGVSLNEAGQGDLSALV 2225
Fly 2226 RCGATEVPHTIRGPSKTGVYEIVYQPTRVAPHKISILFNEVPISLKPLEINVLPASAG--KEISV 2288
Fly 2289 SGLGLYQSRVGKTTSFAIDTVKRPAREFDVVVSGPGGQALPVRCYQTKNGHLQAEFTINKPGQCV 2353
Fly 2354 IEVLHQSKPLPGSPFTCESFDSSKVSTQGVTKE------------------PLALHSPNSF---- 2396
Fly 2397 -------------------TVRTD----------------------------------------- 2401
Fly 2402 ----------NAGTAELEAFAISPSNQSIPVLISEQSDGVYNVEFVPSQPGNYKLTLMYGGETIP 2456
Fly 2457 SSPLNFTAS--SSGVRNDARAAGHGLEVCHRNKEASFVVYCPIAPNVQIERLDEYGERIEPKIKA 2519
Fly 2520 LGNNEWRISYTILSVGKYEIRASCPNRGSLPGSPWHISCVESNKVTPVGGWGTLVDHDGRLILPA 2584
Fly 2585 RIIFDVENAGPGKLVCSIDGIEIPVDKLVDGKMCLNITGENLAAGEHDLDLTWSGLTITQCPRSA 2649
Fly 2650 FVTGQQAADKVQLMG-RGLAAAQAGEAAHFTIDAS-NAPAGRPEVILTSQ-DNTSLPVSLAQPRP 2711
Fly 2712 SENIWLASYTPLKSTTGTLNLSVKWNGRLVKGCPLTVAVGSSM---DASKVIVSGEGLRHGIVGK 2773
Fly 2774 DIKSWIDTRRAGPGELTAHCAGVRKVAY-CELYDHGD-ATFTLNIKPQESGRHILTIKYGG-QNV 2835
Fly 2836 PGSPFALKVAG-------------------------------------APDASKVRVYGPGIEHG 2863
Fly 2864 VLATFQSRFICDTRGAGAGQLTVRVRGPKGAFRVEMQRESQKDRTILCKYDPTEPGDYRVEVKWA 2928
Fly 2929 GEFVPGSPFPVMI 2941 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
jbug | NP_001261140.1 | CH | 60..165 | CDD:237981 | 48/104 (46%) |
CH | 172..269 | CDD:278723 | 44/96 (46%) | ||
CH | 281..371 | CDD:278723 | 7/89 (8%) | ||
IG_FLMN | 468..560 | CDD:214720 | 26/110 (24%) | ||
Filamin | 468..554 | CDD:279024 | 24/104 (23%) | ||
Filamin | 557..644 | CDD:279024 | 27/94 (29%) | ||
IG_FLMN | 560..648 | CDD:214720 | 27/95 (28%) | ||
Filamin | 1116..1200 | CDD:279024 | 20/88 (23%) | ||
IG_FLMN | 1119..1198 | CDD:214720 | 16/83 (19%) | ||
Filamin | 1210..1294 | CDD:279024 | 16/83 (19%) | ||
Filamin | 1299..1383 | CDD:279024 | 28/88 (32%) | ||
IG_FLMN | 1310..1389 | CDD:214720 | 27/83 (33%) | ||
Filamin | 1386..1473 | CDD:279024 | 22/90 (24%) | ||
IG_FLMN | 1399..1480 | CDD:214720 | 18/84 (21%) | ||
Filamin | 1477..1563 | CDD:279024 | 26/94 (28%) | ||
IG_FLMN | 1480..1569 | CDD:214720 | 26/97 (27%) | ||
Filamin | 1570..1653 | CDD:279024 | 23/86 (27%) | ||
IG_FLMN | 1575..1659 | CDD:214720 | 25/87 (29%) | ||
Filamin | 1657..1741 | CDD:279024 | 32/93 (34%) | ||
IG_FLMN | 1661..1747 | CDD:214720 | 32/99 (32%) | ||
Filamin | 1756..1830 | CDD:279024 | 16/77 (21%) | ||
Filamin | 1834..1919 | CDD:279024 | 20/99 (20%) | ||
IG_FLMN | 1837..1926 | CDD:214720 | 22/100 (22%) | ||
IG_FLMN | 1936..2023 | CDD:214720 | 18/86 (21%) | ||
Filamin | 1941..2017 | CDD:279024 | 15/75 (20%) | ||
Filamin | 2021..2111 | CDD:279024 | 27/96 (28%) | ||
IG_FLMN | 2025..2114 | CDD:214720 | 27/99 (27%) | ||
Filamin | 2187..2268 | CDD:279024 | 5/80 (6%) | ||
Filamin | 2279..2369 | CDD:279024 | 21/91 (23%) | ||
IG_FLMN | 2285..2375 | CDD:214720 | 21/89 (24%) | ||
Filamin | 2372..2459 | CDD:279024 | 28/178 (16%) | ||
IG_FLMN | 2376..2465 | CDD:214720 | 32/180 (18%) | ||
IG_FLMN | 2474..2561 | CDD:214720 | 20/86 (23%) | ||
Filamin | 2474..2555 | CDD:279024 | 20/80 (25%) | ||
IG_FLMN | 2657..2751 | CDD:214720 | 24/96 (25%) | ||
Filamin | 2657..2745 | CDD:279024 | 23/90 (26%) | ||
Filamin | 2755..2840 | CDD:279024 | 29/87 (33%) | ||
IG_FLMN | 2756..2847 | CDD:214720 | 33/130 (25%) | ||
Filamin | 2847..2937 | CDD:279024 | 32/89 (36%) | ||
IG_FLMN | 2850..2944 | CDD:214720 | 34/92 (37%) | ||
FLNC | NP_001449.3 | actin-binding domain | 1..268 | 101/241 (42%) | |
Actin-binding | 1..259 | 97/224 (43%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..28 | ||||
CH | 37..141 | CDD:237981 | 48/103 (47%) | ||
CH | 165..257 | CDD:214479 | 43/91 (47%) | ||
Filamin 1 | 270..368 | 23/201 (11%) | |||
Filamin | 274..365 | CDD:279024 | 23/194 (12%) | ||
IG_FLMN | 275..371 | CDD:214720 | 25/202 (12%) | ||
Filamin 2 | 370..468 | 22/97 (23%) | |||
Filamin | 373..464 | CDD:279024 | 18/90 (20%) | ||
IG_FLMN | 375..471 | CDD:214720 | 21/95 (22%) | ||
Filamin 3 | 469..565 | 27/96 (28%) | |||
Filamin | 471..562 | CDD:279024 | 26/91 (29%) | ||
IG_FLMN | 474..567 | CDD:214720 | 27/93 (29%) | ||
Filamin 4 | 566..658 | 18/108 (17%) | |||
Filamin | 569..655 | CDD:279024 | 18/102 (18%) | ||
IG_FLMN | 572..661 | CDD:214720 | 18/105 (17%) | ||
Filamin 5 | 662..758 | 22/141 (16%) | |||
Filamin | 665..755 | CDD:279024 | 19/121 (16%) | ||
IG_FLMN | 667..761 | CDD:214720 | 20/125 (16%) | ||
Filamin 6 | 759..861 | 25/229 (11%) | |||
Filamin | 762..858 | CDD:279024 | 25/223 (11%) | ||
IG_FLMN | 764..864 | CDD:214720 | 25/227 (11%) | ||
Filamin 7 | 862..960 | 25/110 (23%) | |||
Filamin | 866..957 | CDD:279024 | 24/103 (23%) | ||
IG_FLMN | 867..963 | CDD:214720 | 24/108 (22%) | ||
Filamin 8 | 961..1056 | 19/105 (18%) | |||
Filamin | 963..1052 | CDD:279024 | 18/99 (18%) | ||
IG_FLMN | 967..1060 | CDD:214720 | 19/103 (18%) | ||
Filamin 9 | 1057..1149 | 28/98 (29%) | |||
Filamin | 1059..1146 | CDD:279024 | 27/93 (29%) | ||
IG_FLMN | 1062..1151 | CDD:214720 | 28/95 (29%) | ||
Filamin 10 | 1150..1244 | 22/93 (24%) | |||
Filamin | 1152..1239 | CDD:279024 | 21/86 (24%) | ||
IG_FLMN | 1155..1247 | CDD:214720 | 20/91 (22%) | ||
Filamin 11 | 1245..1344 | 27/99 (27%) | |||
Filamin | 1247..1341 | CDD:279024 | 26/94 (28%) | ||
IG_FLMN | 1251..1347 | CDD:214720 | 26/96 (27%) | ||
Filamin 12 | 1345..1437 | 25/93 (27%) | |||
Filamin | 1348..1434 | CDD:279024 | 24/87 (28%) | ||
IG_FLMN | 1350..1439 | CDD:214720 | 25/90 (28%) | ||
Filamin 13 | 1438..1533 | 32/95 (34%) | |||
Filamin | 1440..1530 | CDD:279024 | 30/90 (33%) | ||
IG_FLMN | 1443..1536 | CDD:214720 | 31/93 (33%) | ||
Filamin 14 | 1534..1630 | 21/98 (21%) | |||
Filamin | 1538..1627 | CDD:279024 | 20/91 (22%) | ||
IG_FLMN | 1539..1633 | CDD:214720 | 22/96 (23%) | ||
Filamin | 1634..1731 | CDD:279024 | 21/98 (21%) | ||
Filamin 15 | 1635..1734 | 22/100 (22%) | |||
IG_FLMN | 1636..1732 | CDD:214720 | 21/97 (22%) | ||
Hinge I | 1734..1766 | 2/31 (6%) | |||
Hinge 1 | 1735..1758 | 1/22 (5%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1740..1765 | 0/24 (0%) | |||
Filamin 16 | 1759..1853 | 18/115 (16%) | |||
IG_FLMN | <1795..1855 | CDD:214720 | 16/81 (20%) | ||
Filamin | <1795..1849 | CDD:279024 | 14/75 (19%) | ||
Filamin 17 | 1854..1946 | 28/99 (28%) | |||
Filamin | 1856..1943 | CDD:279024 | 26/94 (28%) | ||
IG_FLMN | 1862..1948 | CDD:214720 | 27/93 (29%) | ||
Filamin 18 | 1947..2033 | 22/165 (13%) | |||
Filamin 19 | 2036..2128 | 22/99 (22%) | |||
Filamin | 2039..2125 | CDD:279024 | 20/87 (23%) | ||
IG_FLMN | 2041..2130 | CDD:214720 | 23/96 (24%) | ||
Intradomain insert, mediate targeting to Z lines | 2162..2243 | 3/80 (4%) | |||
Filamin | <2238..2302 | CDD:279024 | 18/63 (29%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 2240..2260 | 5/19 (26%) | |||
IG_FLMN | <2244..2308 | CDD:214720 | 21/63 (33%) | ||
Filamin 20, mediates interaction with XIRP1 | 2244..2306 | 20/61 (33%) | |||
Filamin 21 | 2309..2401 | 22/101 (22%) | |||
IG_FLMN | 2314..2402 | CDD:214720 | 22/97 (23%) | ||
Filamin | 2314..2398 | CDD:279024 | 20/93 (22%) | ||
Interaction with INPPL1. /evidence=ECO:0000269|PubMed:11739414 | 2403..2724 | 102/417 (24%) | |||
Filamin | 2407..2493 | CDD:279024 | 31/172 (18%) | ||
Filamin | 2502..2589 | CDD:279024 | 30/90 (33%) | ||
IG_FLMN | 2505..2595 | CDD:214720 | 32/93 (34%) | ||
Self-association site, tail. /evidence=ECO:0000250 | 2593..2725 | 36/134 (27%) | |||
Hinge II | 2593..2630 | 1/36 (3%) | |||
Hinge 2 | 2593..2629 | 1/35 (3%) | |||
Filamin | 2632..2721 | CDD:279024 | 33/90 (37%) | ||
IG_FLMN | 2635..2724 | CDD:214720 | 34/90 (38%) | ||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E2759_KOG0518 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 1 | 1.010 | - | - | D35998at2759 | |
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 1 | 0.900 | - | - | OOG6_100805 | |
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
4 | 3.720 |