DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment jbug and fln-1

DIOPT Version :10

Sequence 1:NP_001261140.1 Gene:jbug / 43997 FlyBaseID:FBgn0028371 Length:2990 Species:Drosophila melanogaster
Sequence 2:NP_001294364.1 Gene:fln-1 / 176855 WormBaseID:WBGene00022048 Length:2259 Species:Caenorhabditis elegans


Alignment Length:3077 Identity:609/3077 - (19%)
Similarity:989/3077 - (32%) Gaps:1118/3077 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 IRGNEDLWVEIQANTFRNWVNEHLRETGMQVHDWATDFCDGTCLCALVENLQTRPLKPSWNRRPA 114
            ||.::..|..||.|||..||..||::.|..:....|||.||..|.||.:.|..:.: ..:|::.|
 Worm    17 IRHDDAEWKIIQQNTFTRWVKNHLQKAGETIESLETDFSDGLKLIALAQVLSHKNV-GKFNKKVA 80

  Fly   115 NQHHYLENATTALKSIE-ADHIKLVNIGNVDIVNGNIKLILGLIWSLIVRYQIG----------- 167
            .:...|||.:.||...: .::||::||.:..||:.|.||||||:|:||:.|.|.           
 Worm    81 FRSQKLENVSLALNFFQNEENIKIINIDSTHIVDHNKKLILGLVWTLILHYSISMGWIQEKREDG 145

  Fly   168 -RSKFPPRKLMLAWLQAALP--DCRITNLTTDWNSGVNLAALLDYCQPGLFPHWRSLDPSQSVRN 229
             ..:..|::.:|.|::..||  ...|:|.|:|||.||.|.||::...||....|.:..|:.::.|
 Worm   146 DNKEETPKQKLLNWIRNRLPVSGMPISNFTSDWNDGVALGALVNSMAPGALEDWENWSPNDALEN 210

  Fly   230 CTQAMDLAQREFGVPKVLEPEYLASPWLDELSGMTYLSYF-------MKPGGPGYNATMRWVN-- 285
            ..:||..||....|..::.|..:..|.:||:|.|||||.|       ||   |...||:..::  
 Worm   211 TEKAMKSAQDLLKVAPLIAPAEMIHPEIDEMSVMTYLSQFPATKPIIMK---PKVQATISNLDKI 272

  Fly   286 TQVKDPVKNFTTDWNDGRVMCEIIKGLGGSAPAPEKLSTDPFHYENNIRKAVDAGARLGVQPILT 350
            .||.|| :.|..                       |||.|                  |.:|.::
 Worm   273 LQVNDP-REFDL-----------------------KLSRD------------------GFKPKVS 295

  Fly   351 AKDMANPEVEHLGIMAYAAHLQWVPPRPPLSDLVSVY-LESTSGRVGEPTHFRIDVMSRDISL-- 412
            .:|....:: ||.:             ..:.|..:.| ::.|..::|   ...:||.:.|:..  
 Worm   296 IRDEDGQDI-HLSL-------------KKVEDKENAYKVKFTPTKIG---FIHVDVAANDVHTFE 343

  Fly   413 ------SSVRCHVVPPSGQPGQPVRLNAHGEGVFVPERYGMHEIVVEIGEDSLGGHFFRALPRLL 471
                  :||.|.|||.:       ||..:.:             ..::|:|              
 Worm   344 TQTIPEASVICQVVPIA-------RLLDYNK-------------TAKVGDD-------------- 374

  Fly   472 QVAPPGMAPCALGSLVEVLVNATGAPKTEDILVTAVSPTGISHNCPLKKIDEGHSAIFKPDEAGI 536
                          :...:|:|...|    :....|.|||..|...:                  
 Worm   375 --------------VKFAVVDAIEGP----VEAIVVDPTGKEHRMVI------------------ 403

  Fly   537 WEIAITYQGRHIQGGPFTCAVFDASGVSVHGLDGAMPLRAHTFEVDARGVGVSGELH-VDIVHDK 600
                                           |||..| ..|:||.....:|    || |::.|.|
 Worm   404 -------------------------------LDGTSP-GEHSFEYKIPCIG----LHSVNVFHKK 432

  Fly   601 HSLVCSVEKIVENKYRVTFMPRQNGKYRVYIYFNGYDVKGSPFIMRVGTKGRSGKTRSSPLHDSK 665
            ..|.                                   ||||.:|       ||.:        
 Worm   433 LPLT-----------------------------------GSPFPLR-------GKPK-------- 447

  Fly   666 HRSESPSMHFVSTTNTRHNDYRNSSLSRHNTAERTNSY-------SPQYSPKLDTTDYHSSSSRY 723
                                               ||:       :|:...|.|....|..|   
 Worm   448 -----------------------------------NSFKVWGRGIAPEGIRKNDVVGVHVES--- 474

  Fly   724 YKRESEENHATPPPAPPPASGSPTVKYLNSADLYTETLNGRRDSKTSNSSSTKNDYYYDKENELY 788
              .:.|||.|                   :|::..|.|      |.|:.|               
 Worm   475 --LDPEENIA-------------------NANISLEVL------KPSDGS--------------- 497

  Fly   789 SQRRAVTKPKLTPPREERELTSTTNTSSSSSFQQRHQQLATSTLTRSLSPIPSPTLNTRSSEVHT 853
                                                                             
 Worm   498 ----------------------------------------------------------------- 497

  Fly   854 HSPLTIKTSNQYESSTRNITSSPRHASVSPVQRYSPNSAYITTATHRMGSPLTSPVSKNGYESSR 918
            |.|:::..::  ||.:.:...||:.|                                       
 Worm   498 HLPVSVGYND--ESQSMDFEYSPKQA--------------------------------------- 521

  Fly   919 TVEKSSTYKSTSNYVTDSNIRASPSLYGTAERLRRTGSPEPRIDHSSNVRVSSMKPASARRDSWD 983
                                                                             
 Worm   522 ----------------------------------------------------------------- 521

  Fly   984 VINKTKHMLSHNSLESLANMTEKQLNTELQYNRPDLDHETHRNTQYNKFALHKQQQQQSDYRRDS 1048
                                                                             
 Worm   522 ----------------------------------------------------------------- 521

  Fly  1049 PDDGE-RYKPSAITVKSHSNNTYTDKSGGYTKTVKESSEHVVTESNGHGPSPGYGYSSLSRFRPI 1112
            |||.| ..|.:...::||                   ..||..||:             |:.|  
 Worm   522 PDDLEVLVKVAGEVIESH-------------------KIHVAPESS-------------SKIR-- 552

  Fly  1113 DGNATGARAIRVQDIPNGSIGRPVEFEIDGSRAGSGNLEILVNGGRVTSSVRSLGGQR-----FI 1172
               |.||      .:..|.:..|..|::: ....|.:|...|.|    .|...:|.|.     .|
 Worm   553 ---AFGA------GLEGGIVNEPCVFDVE-MNGESKDLSFAVEG----PSKAEIGCQERPDGSAI 603

  Fly  1173 ASFTPHEHGTHTVQITFNGETVPGSPWHAEIM--------SSPGLTALGES-------------- 1215
            .|:||...|.:.|.:..:|:.:..||:...:.        |:..:|.:.||              
 Worm   604 LSYTPTVAGVYKVGVLADGKHIQDSPFVLRVTEPIEGLKPSATRVTGIDESKVYNVGEKIPFRVD 668

  Fly  1216 TRLVPANTPAVFEILPPPGQSLSKGECVATVLTPSKSKLNARVTHEAANGAARIEFVPTEVGTHV 1280
            |||...:.....|||.|....:|.|   |..:||               |......:|.....|.
 Worm   669 TRLCGVDLVPKVEILDPELNPISYG---AREITP---------------GLFEYTLIPDAPIKHK 715

  Fly  1281 IDASINGTKIAGGPLIAKV---YDSSLIQV--TEVNGGVVG-QACQFRVDASAAGEGQLEISINE 1339
            ||.|:.|..:.|.|...||   .|:|.:::  ..|:|.|.. :..:|.:||:.||.|.:|:::.:
 Worm   716 IDVSVAGVSVPGAPFSVKVKEPTDASKLKIFGPGVDGPVYSKEPTRFTIDATQAGPGAVEVALRD 780

  Fly  1340 GEVPN-HVQVVGG--GRCLVSFTPEQAKSHLIDIKFNGETVRGCPFVCAV---ADTS-------- 1390
            .:..| .:.|:..  |...|.:|.::..::.:::.|.||.:  .|....|   .|.|        
 Worm   781 DQGENVDLDVLDNQDGSFTVKYTAQRPGAYQLNVVFAGEEI--SPIEINVKPNVDVSGIRVEGLE 843

  Fly  1391 ----------RVLLNLSNLELIPVNRPSSFHITVSGGGAAELAVSVRGPQGELPVRVTGDIHAGF 1445
                      |..:|:..||      |.|        ...:|...|.|.:..:|:::..|   |.
 Worm   844 NENLLIGSHLRPTINIGKLE------PKS--------KGLQLIDEVNGKRYNVPMKINPD---GT 891

  Fly  1446 TAEFTP-TTVGGHSINVEYNGFAV-QGTPFLAKSYDASKVVV--GSVSRGTMGRPVQFTVDAGDA 1506
            .:..|| ..||.|.:.:.::...| :....:.|..|.:|...  ..:.:..:|....|.:|...|
 Worm   892 YSTDTPLMEVGEHKLQLLFDEIPVKEAVVEVIKGTDVNKCKAYGPGLEQAVVGEKAVFELDLDGA 956

  Fly  1507 GEG--NLEITISAKGQNIPTQVHPQGSARFSVSFVPTESCEHTINVSF----NKMPVPGCPITVS 1565
            |||  ::|:...||.:   :::..:|:.:.||.:|.....::.:.:.|    .|..|.|.|....
 Worm   957 GEGALSMEMRGPAKAE---SRIQDRGNGKCSVEYVAKAPGDYEMAIKFGKDEQKEHVKGSPFKAV 1018

  Fly  1566 ISGGVAGPQVSLGG-PGPVHQTN---SFVINHNGGRLEDIEVNVEGPAGQSVPAQVHQSADGVFK 1626
            :.......|:::.| ..|.::.|   :|||:.:  :.:|:      |...:||:...|....|.:
 Worm  1019 VDYKKDPSQITISGLDQPNYRLNQPINFVIDTS--KTKDL------PVKATVPSDFAQLQPVVSR 1075

  Fly  1627 AEFVPRVVGEHRVNVTVNGLPTAGSPYAAKVYDVSAI--KVKNVSSGTVGKAVTFLVETSQAGPG 1689
            :...||   .|.|....:|.|....|... :||...|  |:..|......:.:..|.:..:....
 Worm  1076 SPSNPR---HHNVRFVPSGKPNVSIPIEI-IYDGLKIDEKLVKVLPEVEPQLIKILHDKKKDSLT 1136

  Fly  1690 NLEVTVNG---GRVPTSAQAQG------------------QHT--------YAISFTPREAESHT 1725
            ...:|.|.   |.||...:..|                  .|.        |.:||....|..:.
 Worm  1137 TTPITTNASHEGHVPFDVRDCGNVKKIESRVFGPDGKERLNHVRSTEQNGIYDVSFPTDMAGEYC 1201

  Fly  1726 VELRFNSQDVPGSPFTCRVAAAARIQSPETMDKVSVGRLFEFVVE--------SDTKPTV----- 1777
            |....|.|:|           |||:  |...:|  :||..:.:.|        ::..|||     
 Worm  1202 VVFYINGQEV-----------AARV--PVMAEK--IGRKEDVIKEEIVFHPEIAEHSPTVLTYNH 1251

  Fly  1778 ------EVLGPARRSVPVKIDALGSSTLGYNVKFEPMEVGDHSVEVRLPGGGHVEGSPFLLKAYS 1836
                  :...||.:.:..|.||         |:.|.::        .|...||          ..
 Worm  1252 PIDAKKKKAHPAIQVLAAKPDA---------VRLEHIQ--------ELVDNGH----------RV 1289

  Fly  1837 AEKVIVTDIRAGVVNKSVSFG------INASQAGAGNLEIIVAVNGKNVPNFVQSEGNA-RFKVN 1894
            |::::.|..:.|.....|.:|      :.....|....|.|.|...|.|   |:.|.:. :::..
 Worm  1290 ADRIVFTATKLGTNTLDVFYGGEHVDHVEYEAIGKLEYERIQAERAKVV---VEKEDDVDKYEKQ 1351

  Fly  1895 FK--PTEAATHSLSVRFNGHPVPGSPFSCHIAAAAASPSMGLPRAMAMGECLKQAAVKMDNTFEL 1957
            :|  |:.|.........||.    .|     ..|..|...|..:.:|....::...::...||:.
 Worm  1352 YKDEPSSAPADPRVAPTNGK----EP-----TTAQESKKNGNQQKLAPSAEIEHKPLEKYFTFQF 1407

  Fly  1958 EGFD-GVEP---QIFVTSPSGDNEHCQLSQHDGGSYSASFRPTTVGRHLISVTANDQHINGSPFS 2018
            ...| |.:|   :..|..|:...|..::..:..|:....:.|...|.|.:|:..|...:.|:|..
 Worm  1408 NVRDLGYQPKDLEAIVMPPTQKKEVAEIIDNLDGTILVKYTPKVHGSHELSILQNGAQLQGTPIK 1472

  Fly  2019 CNVFDVSRVSISGLEQQYGP----ANLGVPVTFSVDAAGAGEGTLELVVSTD---SSTVKAEVVA 2076
               |.|.... .|....|||    |.:|.|.||:|.|.|:  ...||.||.:   .|.:|  :..
 Worm  1473 ---FYVDAYG-DGWATVYGPGLQNAVVGEPATFTVCAKGS--QAKELSVSIEGPAKSQIK--IHD 1529

  Fly  2077 CARGLYDVTFVPQSTEPHYVNITFNEVAVDGSPFRVDIQ---QHTQHIQIGSLAAIDFPADDQIV 2138
            ...|.....:||.....:.|::.....||..|||||.:.   |...|:.:||.:.:..|...|.:
 Worm  1530 NKDGTCSAAWVPPVPGEYKVHVKLGGKAVKDSPFRVLVMGEGQKRSHLSVGSTSEVALPITQQEL 1594

  Fly  2139 EIFSPDQKSVPYSINRQTAEFRTHMTGNYTLRFIDRETRQHI----GSRTLCVFDPTLVKI--TE 2197
            :..|...|| |..| .:....|....|...:.|..||..:|:    ....|....|..:|:  |:
 Worm  1595 KGISASIKS-PGGI-EEPCFVRLLDGGRLGVSFTPREAGEHLITVKRDGKLVPKAPFKIKVDKTQ 1657

  Fly  2198 VSEAFCHRPASIG-------------VSLNEAGQGDLSALVRCGATEVPHTIRGPS--------- 2240
            |.:|.....:..|             |..::||.|.||.           :::|||         
 Worm  1658 VGDASKVEVSGSGKAKGITLQANELLVDTSKAGYGGLSV-----------SVQGPSKAELTCKEV 1711

  Fly  2241 KTGVYEIVYQPTRVAPHKISILFNEVPISLKPLEINVLPASAGKEISVSGLGLYQSRV---GKTT 2302
            |:|:.:::|.||....:.|:|.|.:..:...||.:.....|||:.|......:.|..:   .:.:
 Worm  1712 KSGLIKVLYTPTEPGVYAIAIKFADHHVKDSPLTVQCTGKSAGRVIQTIQKDVEQHGICLPDQES 1776

  Fly  2303 SFAIDTVKRPAREFDVVVSGPGGQALPVRCYQTKNGHLQAEFTINKPGQCVIEVLHQSKPLPGSP 2367
            ...:..:.....:....:..|.|....:........:.|.:||....|...:.|:::...:.|||
 Worm  1777 HLFLKLLNTSPMDITARLMDPKGHTDDIEMRDLGQQYYQLKFTPKMEGIHTLSVMYKDAHVNGSP 1841

  Fly  2368 --FTCESFDSS-----KVSTQGVTKEPLALHSPNSFTVRTDNAGTAELEAFAISPSNQSIPVLIS 2425
              ||..||...     :.:.|||.:......  |:|.:....||...:......||..::.  ..
 Worm  1842 FQFTVGSFSEGGAHKVRAAGQGVVRGETGTF--NAFNIYHREAGVGAVAVTIEGPSKATLE--FK 1902

  Fly  2426 EQSDGVYNVEFVPSQPGNYKLTLMYGGETIPSSPLNFTASSSGVRNDARAAGHGLEVCHRNKEAS 2490
            :.:||..:|::..:.||.|.:.:.:..:.||.||                               
 Worm  1903 DHNDGNCHVDYKVATPGEYVVAVKFNDQHIPDSP------------------------------- 1936

  Fly  2491 FVVYCPIAPNV----QIERLDEYGERIEPKIKALGNNEWRISYTILSVGKYEIRASCPNRGSLPG 2551
            |.||  |||..    ::|....:|:.| |..||       .::|:|:     .||    :|.|  
 Worm  1937 FKVY--IAPATGEVRKLELAQFHGQGI-PAGKA-------FTFTVLT-----HRA----KGHL-- 1980

  Fly  2552 SPWHISCVESNKVTPVGGWGTLVDHDGRLILPARIIFDVENAGPGKLVCSIDGIEI-PVDKLVDG 2615
                    |:..|||..                                .:|.|:| |::     
 Worm  1981 --------EAKVVTPNN--------------------------------EVDTIDIVPIE----- 2000

  Fly  2616 KMCLNITGENLA-------AGEHDLDLTWSGLTITQCPRSAFVTGQQAAD--KVQLMGRGLAAAQ 2671
                  .||:.|       .|.|.:.:|..|..:.:.|....|.|:...|  .:...|.||....
 Worm  2001 ------DGESYAMRFVPKETGNHFIHVTLDGAPMRESPFRLRVGGKDLCDPTAISASGDGLVKGT 2059

  Fly  2672 AGEAAHFTIDASNAPAGRPEVILTSQDNTSLPVSLAQPRPSENIWLASYTPLKSTTGTLNLSVKW 2736
            .|:...|.|:.:||.||    |||.|.:.....:| .....|..:...||||  ..|:...|||:
 Worm  2060 TGQKCEFVINTANAGAG----ILTVQMDGPSKATL-DAYELEKGYKVRYTPL--APGSYFASVKY 2117

  Fly  2737 NGRLVKGCPLTVAV-GSSM--------------------------------DASKVIVSGEGLRH 2768
            ||....|.|..:.| |..:                                ||:||...|.||..
 Worm  2118 NGIHAPGSPFKIPVEGKELGGNGYNETSHVKIDAVAKTSKGTVAVVPEYQGDAAKVTAKGAGLNK 2182

  Fly  2769 GIVGKDIKSWIDTRRAGPGELTAHCAGVRKVAYCELYDHGDATFTLNIKPQESGRHILT------ 2827
            ...|:.....|||..||...|..  ..|.....||         .:.::.|.||.::.:      
 Worm  2183 FFPGRPAAFQIDTGLAGTNLLMV--GVVTTKGPCE---------EVVVRHQGSGHYVCSYRIPDR 2236

  Fly  2828 ------IKYGGQNVPGSPFALK 2843
                  ||||.:.:||||||::
 Worm  2237 VKGFVFIKYGDKEIPGSPFAIE 2258

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
jbugNP_001261140.1 CH_jitterbug-like_rpt1 57..166 CDD:409076 44/109 (40%)
CH_jitterbug-like_rpt2 170..274 CDD:409078 39/112 (35%)
CH_jitterbug-like_rpt3 275..373 CDD:409034 17/99 (17%)
IG_FLMN 468..560 CDD:214720 8/91 (9%)
IG_FLMN 560..648 CDD:214720 19/88 (22%)
IG_FLMN 1119..1198 CDD:214720 18/83 (22%)
IG_FLMN 1220..1302 CDD:214720 20/84 (24%)
IG_FLMN 1310..1389 CDD:214720 20/85 (24%)
IG_FLMN 1399..1480 CDD:214720 17/82 (21%)
IG_FLMN 1480..1569 CDD:214720 20/96 (21%)
IG_FLMN 1575..1659 CDD:214720 19/87 (22%)
IG_FLMN 1661..1747 CDD:214720 19/116 (16%)
IG_FLMN 1757..1837 CDD:214720 17/98 (17%)
IG_FLMN 1837..1926 CDD:214720 19/97 (20%)
IG_FLMN 1936..2023 CDD:214720 17/90 (19%)
Filamin 2021..2111 CDD:395505 28/96 (29%)
IG_FLMN 2198..2280 CDD:214720 22/103 (21%)
IG_FLMN 2285..2375 CDD:214720 16/94 (17%)
IG_FLMN 2376..2465 CDD:214720 19/93 (20%)
Filamin 2474..2555 CDD:395505 18/84 (21%)
IG_FLMN 2657..2751 CDD:214720 30/96 (31%)
IG_FLMN 2756..2847 CDD:214720 29/100 (29%)
IG_FLMN 2850..2944 CDD:214720
fln-1NP_001294364.1 CH_dFLNA-like_rpt1 13..136 CDD:409160 47/119 (39%)
CH_FLN_rpt2 151..255 CDD:409079 37/103 (36%)
IG_FLMN 261..358 CDD:214720 27/155 (17%)
IG_FLMN 367..446 CDD:214720 30/219 (14%)
IG_FLMN 549..637 CDD:214720 24/103 (23%)
IG_FLMN 643..737 CDD:214720 27/111 (24%)
IG_FLMN 740..830 CDD:214720 21/91 (23%)
IG_FLMN 930..1020 CDD:214720 20/92 (22%)
IG_FLMN <1406..1476 CDD:214720 15/72 (21%)
IG_FLMN 1484..1567 CDD:214720 28/86 (33%)
Filamin 1561..1650 CDD:395505 24/90 (27%)
IG_FLMN 1661..1750 CDD:214720 21/99 (21%)
Filamin <1789..1842 CDD:395505 9/52 (17%)
IG_FLMN 1854..1944 CDD:214720 24/126 (19%)
IG_FLMN 1959..2039 CDD:214720 27/149 (18%)
IG_FLMN 2045..2133 CDD:214720 29/94 (31%)
IG_FLMN 2170..2258 CDD:214720 29/98 (30%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.