Protein Alignment jbug and cher

DIOPT Version :10

• Sequence 1: NP_001261140.1
• Gene: jbug / 43997
• FlyBaseID: FBgn0028371
• Length: 2990
• Species: Drosophila melanogaster
• Sequence 2: XP_061502782.1
• Gene: cher / 1274482
• VectorBaseID: AGAMI1_012082
• Length: 2523
• Species: Anopheles gambiae
• Alignment Length: 3197
• Identity: 687/3197 - (21%)
• Similarity: 1078/3197 - (33%)
• Gaps: 1032/3197 - (32%)

  Fly    57 WVEIQANTFRNWVNEHLRETGMQVHDWATDFCDGTCLCALVENLQTRPLKPSWNRRPANQHHYLE 121
            |..||.|||..|.||||:.....:.:..:|..||..|.||:|.|..:.:. ..|:||..:...||
Mosquito    47 WKRIQQNTFTRWANEHLKIINQTIANLESDLSDGLRLIALIEVLSQKRMS-KHNKRPTFRSQKLE 110

  Fly   122 NATTALKSIEADHIKLVNIGNVDIVNGNIKLILGLIWSLIVRYQI----------------GRSK 170
            |.:.|||.:|.:.||:|||.:.|||:..:|||:||||:||:.|.|                |...
Mosquito   111 NVSVALKFLEVEGIKIVNIDSSDIVDCKLKLIMGLIWTLILHYSISLPMWEGDENGDNLANGNGA 175

  Fly   171 FPPRKLMLAWLQAALPDCRITNLTTDWNSGVNLAALLDYCQPGLFPHWRSLDPSQSVRNCTQAMD 235
            .|.::|| .|:...:||..|.|.|:||.:|..:.||:|...|||.|.|...||..:|:|..:||.
Mosquito   176 SPKQRLM-NWIHRLVPDLPINNFTSDWTNGKAVGALVDAVAPGLCPDWPMWDPKDAVQNAAEAMG 239

  Fly   236 LAQREFGVPKVLEPEYLASPWLDELSGMTYLSYF----MKPGGPGYNATMRWVNTQVKDPVKNFT 296
            ||.....|.:::.||.:.:|.:||.|.|||||.:    :|||.|
Mosquito   240 LADDWLNVRQLIRPEEMVNPNIDEQSMMTYLSQYPNAKLKPGAP--------------------- 283

  Fly   297 TDWNDGRVMCEIIKGLGGSAPAPEKLSTDPFHYENNIRKAVDAGARLGVQPILTAKDMANPEVEH 361
                                                                      ..|...|
Mosquito   284 ----------------------------------------------------------LRPRTNH 290

  Fly   362 LGIMAYAAHLQWVPPRPPLSDLVSVY---LESTSGRVGEPTHFRIDVMSRDISLSSVRCHVVPPS 423
            ..:         .|||      |..|   :|.|...||.|.:|.::..|.......|..|  .|:
Mosquito   291 SSV---------PPPR------VRAYGPGIEPTGPTVGAPANFTVETFSAGKGNVDVAVH--NPN 338

  Fly   424 GQPGQPVRLNAHGEGVFVPERYGMHEIVVEIGEDSLGGHFFRALPRLLQVAPPGMAPCALGSLVE 488
            |.|.:                                                  ..|...:...
Mosquito   339 GNPEK--------------------------------------------------VDCRFNNDKN 353

  Fly   489 VLVNATGAPKTEDILVTAVSPTGISHNCPLKKIDEGHSAIFKPDEAGIWEIAITYQGRHIQGGPF 553
            :..:.:..||.|                                  |..::.:.:.||.|...|:
Mosquito   354 LTYSVSYIPKLE----------------------------------GPHKVYVKFNGRDIPKSPY 384

  Fly   554 TCAV----FDASGVSVHG----LDGAMPLRAHTFEVDAR--GVGVSGELHVDIVHDKHSLVCSVE 608
            ...|    .|||.|:..|    .||.:..:...|::..:  |.|....:.:|..:.|.|:...:.
Mosquito   385 EVQVESQAGDASKVTATGPGLLPDGVVVGKQTYFDITTKDAGKGTPEVIILDPANHKTSVAAKLR 449

  Fly   609 KIVENKYRVTFMPRQNGKYRVYIYFNGYDVKGSPFIMRVGTKGRSGKTRSSPLHDSKHRSESPSM 673
            ::..:::|..:..:|.|.:.|.::|.|..::|||:.:||.......|.|:|      .|...|
Mosquito   450 QVGTDQWRCEYTAKQVGLHSVNVFFCGQQIRGSPYGVRVAPVCDPRKVRAS------GRGLQP-- 506

  Fly   674 HFVSTTNTRHNDYRNSSLSRHNTAERTNSYSPQYSPKLDTTDYHSSSSRYYKRESEENHATPPPA 738
                 ...|.||                          |...:     |.:...:.|
Mosquito   507 -----VGVRVND--------------------------DDVTF-----RIFTEGAGE-------- 527

  Fly   739 PPPASGSPTVKYLNSADLYTETLNGRRDSKTSNSSSTKNDYYYDKENELYSQRRAVTKPKLTPPR 803
                 |.|.||......                                           :.|..
Mosquito   528 -----GIPEVKIFGPGG-------------------------------------------VVPEH 544

  Fly   804 EERELTSTTNTSSSSSFQQRHQQLATSTLTRSLSPIPSPTLNTRSSEVHTHSPLTIKTSNQYESS 868
            ..|:|.:||..:.....::...::                             |.:..|.:...|
Mosquito   545 SIRKLDATTYEAQYIPLKEGRYKI-----------------------------LVLYGSQEIPKS 580

  Fly   869 TRNITSSP-RHASVSPVQRYSPNSAYITTATHRMGSPLTSPVSKNGYESSRTVEKSSTYKSTSNY 932
            ...:|..| :|.|   :..|.|.     ..:..:|.|....|..||
Mosquito   581 PFEVTVGPQKHTS---IVAYGPG-----LKSGMVGQPACFVVETNG------------------- 618

  Fly   933 VTDSNIRASPSLYGTAERLRRTGSPEPRIDHSSNVRVSSMKPASARRDSWDVINKTKHMLSHNSL 997
                                .||          |:..|...|:.|
Mosquito   619 --------------------ETG----------NLGFSIAGPSQA-------------------- 633

  Fly   998 ESLANMTEKQLNTELQYNRPDLDHETHRNTQYNKFALHKQQQQQSDYRRDSPDDGE---RYKPSA 1059
                                  :.|.|.|                       .||.   :|.|:|
Mosquito   634 ----------------------EIECHDN-----------------------GDGSALVKYHPTA 653

  Fly  1060 ITVKSHSNNTYTDKSGGYTKTVKESSEHVVTESNGHGPSPGYG--YSSLSRFRPIDGNATGARAI 1122
                          .|.|       :.|::.::.....||...  ......|.|.....:|....
Mosquito   654 --------------PGEY-------AVHILCDNEDIPKSPHIAQVLPKADDFHPELVKVSGPGVE 697

  Fly  1123 RVQDIPNGS--IGRPVEFEIDGSRAGSGNLEILVNGGRVTSS------VRSLGGQRFIASFTPHE 1179
            :     ||.  :|:|.||.:|.:||||..||:.:|.  |.|:      .::..|.:.|....|..
Mosquito   698 K-----NGGVIVGKPTEFTVDATRAGSAPLEVKIND--VFSNTIAHKIAQTESGMKKITYTAPSA 755

  Fly  1180 HGTHTVQITFNGETVPGSPWHAEIMS--------------SPGLTALGESTRLVPANTPAVFEI- 1229
            ... ||::.:.|..||.||:...:.:              .||          |..|....|.:
Mosquito   756 EPV-TVEVNYGGVAVPHSPFRVNVSTPLDASKVQFFGPWLEPG----------VKPNAATHFNVD 809

  Fly  1230 LPPPGQSLSKGECVATVLTPSKSKLNARVTHEAANGAARIEFVPTEVGTHVIDASINGTKIAGGP 1294
            ....|..|.:   |..|...||.|:..|:.....|..| :|.:|...||:..:....|.|:...|
Mosquito   810 ARAAGNGLLE---VNLVHEESKQKVPVRIIDNNDNTYA-VEVIPPLPGTYSTNLLYGGLKVPMSP 870

  Fly  1295 --LIAKVYDSSLIQVTEVN-GGVVGQACQFRVDASAAGEGQLEISINE---GEVPNHVQVVGGGR 1353
              .:|...|.|.|:|..:. ...:....||||..:..|:..|.::|..   ..|..||.....|
Mosquito   871 KVTVAPPVDVSKIKVDGLEPTAPLNSLQQFRVITNGIGKADLAVTITSPSGNRVKAHVIPTAEG- 934

  Fly  1354 CLVSFTPEQAKSHLIDIKFNGETVRGCPF--VCAVADTSRVLLNLSNLELIP--VNRPSSFHITV 1414
            .||:|||.|...:|:.:.|.|..:...||  .|.|...|| .:..|...|:.  :|||:.|.|..
Mosquito   935 FLVNFTPTQLGEYLLSVSFGGTPITPQPFRLQCLVGSDSR-KVQASGPGLVRGIINRPAEFMIDT 998

  Fly  1415 SGGGAAELAVSVRGP-QGELPVRVTGDIHAGFTAEFTPTTVGGHSINVEYNGFAVQGTPF---LA 1475
            .|.|...|.|:|.|| :..:..|..||  ......:.||.:|.::||:.:|...:.|:|:   :.
Mosquito   999 RGAGQGGLGVTVEGPCEAAINCRDNGD--GTCNVAYLPTEIGDYTINITFNDDHIAGSPYQAIIV 1061

  Fly  1476 KSYDASKVVV---GSVSRG-TMGRPVQFTVD----AGDAGEGNLEITI-SAKGQNIPTQVHPQGS 1531
            ...:.:|:.|   |....| .|..|..|.||    ..|.....|...| ..:|..||:::.|..|
Mosquito  1062 PEPNLNKIRVSGMGIQPHGVVMNAPTDFLVDMSKVGNDVDRSKLSCNIFDPRGNEIPSKLVPSDS 1126

  Fly  1532 AR--FSVSFVPTESCEHTINVSFNKMPVPGCPITVSISGGVAGPQVSLGGPG----PVHQTNSFV 1590
            |.  |.:.:.|.|:..|||::.::.:||||.|..|::..|....:....|||    ...:..:|.
Mosquito  1127 ADDVFRIMYTPFEAGRHTIDLLYDNVPVPGSPFVVNVKSGCDPSRCRAYGPGLESAMTDKMATFT 1191

  Fly  1591 INHNGGRLEDIEVNVEGPAGQSVPAQVHQSADGVFKAEFVPRVVGEHRVNVTVNGLPTAGSPYAA 1655
            :...|.....:.:.:|||:...:...  .:.||....|::|...||:.|.:........|||:..
Mosquito  1192 VETRGAGAGGLSLAIEGPSEAKMSCT--DNRDGSCDVEYMPTEPGEYDVTIRYADKHIPGSPFRV 1254

  Fly  1656 KVYDVS---AIKV--KNVSSGTV--GKAVTFLVETSQAGPGNLEVTVN---GGRVPTSAQAQGQH 1710
            .|.:.:   .:||  ..:..|.|  |....|.::.|.||||.:.|.::   |..:.|..|.:|..
Mosquito  1255 VVNESTRPEKVKVYGPGIEHGQVYDGLPAQFFIDCSGAGPGKIAVKLSSSEGKPIATQVQDKGDG 1319

  Fly  1711 TYAISFT-PREAESHTVELRFNSQDVPGSPFTCRVAAAA-------------------------R 1749
            .|.:::. |:|....|..:.|..|||..|||...||.|.                         :
Mosquito  1320 VYGVTYVPPKEGSVITANVCFADQDVSCSPFVMTVAPAPNDVPVKVYGDATTKKALPASLPAKFQ 1384

  Fly  1750 IQSPETMDKVSVGRLFEFVVESDTKPTVEVLGPARRSVPVKIDALGSSTLGYNVKFEPMEVGDHS 1814
            |.:|:|..|..:              .|.:.||..:.:..|::.....|  |.|.|.|.|.|.::
Mosquito  1385 IDAPKTKAKEDI--------------NVSIKGPDGKPLVPKMEQEADGT--YGVSFVPDECGPYN 1433

  Fly  1815 VEVRLPGGGHVEGSPFLLKAY---SAEKVIVTDIRAGVVN----KSVSFGINASQAGAGNLEIIV 1872
            |.::. ||..|.||||||:|.   .|:|..:  ::|..||    |...|.::|.:||.|
Mosquito  1434 VSIKC-GGKDVLGSPFLLQAIPTGEADKCKM--VQAVPVNQEYGKKNHFAVDAREAGTG------ 1489

  Fly  1873 AVNGKNVPNFVQS-------EGNARFKVNFKPTEAATHSLSVRFNGHPVPGSPFSC--------- 1921
            ||..|.|.:...|       |.:..|.:.:...:...:.|.::|.|..:|...|:.
Mosquito  1490 AVTCKIVSHSEASDVDIDIIEKDGFFDIFYVLKDPGDYDLDIKFGGQNIPNGTFTIKAVDNVEEE 1554

  Fly  1922 HIAAAAASPSMGLPRAMAMG--------------------ECLKQAA------------------ 1948
            .:..:|.|.|.....|::..                    :.::|.|
Mosquito  1555 QVTKSATSSSKTTSSAISENHSYQHQESYIEQVSSVSKSKQYIQQTASEEFLVRERLVNGKHDSV 1619

  Fly  1949 ---------------------------VKMDN-------------TFELEGFDGVEPQIFVTS-- 1971
                                       .:.||             .|:|:..:..:....||:
Mosquito  1620 STLNSVQQLSASTTTTSNSSATNGNGTTEHDNHLNGTTQSSSRFHVFKLDRLNTPQTGGTVTAEV 1684

  Fly  1972 --PSGDNEHCQLSQHDGGSYSASFRPTTVGRHLISVTANDQHINGSPFSCNVFDVSRVSISGLEQ 2034
              |||:.:...:..:..|:.|..:.|...|.|.::|..|.:|:.||||..:|..:|    ||...
Mosquito  1685 KMPSGEVDKPVIDDNHDGTVSIRYEPKEEGIHELAVKYNGEHVQGSPFKFHVDSIS----SGYVT 1745

  Fly  2035 QYGPANL----GVPVTFSVDAAGAGEGTLELVVSTDSSTVKAEVVACAR--GLYDVTFVPQSTEP 2093
            .|||..:    |.|..|.:...|||.|.|::.|...|   ||::.....  |...|:::|.:...
Mosquito  1746 AYGPGLVHGVTGEPAQFIISTKGAGAGGLQMAVEGPS---KADITYHDNKDGTVSVSYLPTAPGE 1807

  Fly  2094 HYVNITFNEVAVDGSPFRVDIQ---QHTQHIQIGSLAAIDFP---ADDQI----VEIFSPDQKSV 2148
            :.:::.|.:..:.|||:...|.   :....|.:||.:.:..|   :|:.:    ..|.:|.....
Mosquito  1808 YKISVRFGDKHIKGSPYFAKITGEGRKRNQISVGSCSEVTLPGVISDNDLRSLNASIQAPSGLEE 1872

  Fly  2149 PYSINRQTAEFRTHMTGNYTLRFIDRETRQHIGSRTLCVFDPTLVKITEVSEAFCHRPASIGVSL 2213
            |..:.|..       |||..:.|..||    ||..|:.|
Mosquito  1873 PCFLKRMP-------TGNIGISFTPRE----IGEHTVSV-------------------------- 1900

  Fly  2214 NEAGQGDLSALVRCGATEVPHTIRGPSKTGVYEIVYQPTRVAPHKISILFNEVPISLKPLEINVL 2278
                                                  .|:..|          |:..|.::||.
Mosquito  1901 --------------------------------------KRLGKH----------IANSPFKVNVC 1917

  Fly  2279 PASAG--KEISVSGLGLYQSRVGKTTSFAIDTVKRPAREFDVVVSGPGGQALPVRCYQTKNGHLQ 2341
            ....|  |::.|:|..|.:.:..:...|:|||.........:.:.||  ....::|....:|.|.
Mosquito  1918 EREVGDAKKVIVTGNALKEGKTHQDNVFSIDTRNAGYGGLSLSIEGP--SKAEIQCTDKDDGTLN 1980

  Fly  2342 AEFTINKPGQCVIEVLHQSKPLPGSPFTCESFDSSKVSTQGVTKE-----------PLA-LHSPN 2394
            ..:...:||..::.:......:.|||||.      |||.:|..::           |:. :.|..
Mosquito  1981 IAYKPTEPGYYIVNLKFADHHVTGSPFTV------KVSGEGTNRQREKIQRQREAVPITEVGSQC 2039

  Fly  2395 SFTVRTDNAGTAELEAFAISPSNQSIPVLISEQSDGVYNVEFVPSQPGNYKLTLMYGGETIPSSP 2459
            ..|.:.....:.:|.|...||...|....|.|..||:|.|.|:|.:.|.:.:::.|....||.||
Mosquito  2040 KLTFKMPGITSFDLSATVTSPGGVSEDAEIQEIEDGLYAVHFIPKELGVHTVSVKYKQIHIPGSP 2104

  Fly  2460 LNFTASSSGVRND-----ARAAGHGLEVCHRNKEASFVVYCPIAPNVQIERLDEYGERIEPKIKA 2519
            ..||.   |...|     .:|.|.|||...:...|.|.|:...|....:....|...:.|.:.|.
Mosquito  2105 FQFTV---GPLKDTGAHLVKAGGPGLEHGEQGVPAEFNVWTREAGGGTLAISVEGPSKAEIEFKD 2166

  Fly  2520 LGNNEWRISYTILSVGKYEIRASCPNRGSLPGSPWHISCVESNKVTPVGGWGTLVDHDGRLILPA 2584
            ..:....:||.:...|.|.|.....:| .:|.||:.:      .::|
Mosquito  2167 RKDGSCDVSYVVSEPGDYRIGLKFNDR-HIPDSPFKV------YISP------------------ 2206

  Fly  2585 RIIFDVENAGPGKLVCSIDGIEIPVDKLVDGKMCLNITGENLAAGE-HDLDLTWSGLTITQCPRS 2648
                                                      |.|| |.|::            :
Mosquito  2207 ------------------------------------------AMGEAHKLEV------------A 2217

  Fly  2649 AFVTGQQAADK-VQLMGRGLAAAQAGEAAHFTIDAS-NAPAGRPE---VILTSQDNTSLPVSLAQ 2708
            .|.||...||| .|.|.|...|  .||     :||. .||:...:   :.|..||..|:     :
Mosquito  2218 QFPTGCVQADKPAQFMVRKNGA--KGE-----LDAKVVAPSNNEDDCFIQLIDQDQYSV-----R 2270

  Fly  2709 PRPSENIWLASYTPLKSTTGTLNLSVKWNGRLVKGCPLTVAVG-SSMDASKVIVSGEGLRHGIVG 2772
            ..|.||             |...:.||:||..:.|.|..:.|| ..:|.:.|..||:||.....|
Mosquito  2271 FYPREN-------------GIHAIHVKFNGVHIPGSPYRIKVGKDDVDPAAVHASGKGLGDVKTG 2322

  Fly  2773 KDIKSWIDTRRAGPGELTAHCAGVRKVAY-CELYDHGDATFTLNIKPQESGRHILTIKYGGQNVP 2836
            :.....|||..||.|.|.....|..|||. |...:.|   :.:...|...|.:.:||||...::.
Mosquito  2323 EKTDLIIDTCNAGAGTLAVTVDGPAKVAMDCTEVEEG---YKVRYTPLLPGHYYMTIKYNQMHIV 2384

  Fly  2837 GSPFALKVAG------------------------------------APDASKVRVYGPGIEHGVL 2865
            ||||.:...|                                    ..||||::..|.|::...:
Mosquito  2385 GSPFKINCTGESLAEAGGQETSSVIVETVAKVSKGGNRTGVILPIFKSDASKIQSKGMGLKKAYM 2449

  Fly  2866 ATFQSRFICDTRGAGAGQLTVRVRGPKG-AFRVEMQRESQKDRTILCKYDPTEPGDYRVEVKWAG 2929
            .. |::|..:...||...|.|.:.|||| ...|.::...:...|:  .|...|.|||.:.|||..
Mosquito  2450 GK-QNQFTINAGDAGNNILFVGIYGPKGPCDEVFIKHTGRNQYTV--NYLVRERGDYILLVKWGD 2511

  Fly  2930 EFVPGSPFPVMI 2941
            :.:|||||.|.:
Mosquito  2512 DHIPGSPFKVEV 2523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jbug	NP_001261140.1	CH_jitterbug-like_rpt1	57..166	CDD:409076	47/108 (44%)
		CH_jitterbug-like_rpt2	170..274	CDD:409078	42/107 (39%)
		CH_jitterbug-like_rpt3	275..373	CDD:409034	3/97 (3%)
		IG_FLMN	468..560	CDD:214720	10/95 (11%)
		IG_FLMN	560..648	CDD:214720	22/93 (24%)
		IG_FLMN	1119..1198	CDD:214720	24/86 (28%)
		IG_FLMN	1220..1302	CDD:214720	20/84 (24%)
		IG_FLMN	1310..1389	CDD:214720	24/84 (29%)
		IG_FLMN	1399..1480	CDD:214720	24/86 (28%)
		IG_FLMN	1480..1569	CDD:214720	30/99 (30%)
		IG_FLMN	1575..1659	CDD:214720	19/87 (22%)
		IG_FLMN	1661..1747	CDD:214720	29/96 (30%)
		IG_FLMN	1757..1837	CDD:214720	23/82 (28%)
		IG_FLMN	1837..1926	CDD:214720	23/108 (21%)
		IG_FLMN	1936..2023	CDD:214720	25/168 (15%)
		Filamin	2021..2111	CDD:395505	26/95 (27%)
		IG_FLMN	2198..2280	CDD:214720	6/81 (7%)
		IG_FLMN	2285..2375	CDD:214720	19/89 (21%)
		IG_FLMN	2376..2465	CDD:214720	28/100 (28%)
		Filamin	2474..2555	CDD:395505	21/80 (26%)
		IG_FLMN	2657..2751	CDD:214720	27/98 (28%)
		IG_FLMN	2756..2847	CDD:214720	30/127 (24%)
		IG_FLMN	2850..2944	CDD:214720	31/93 (33%)
cher	XP_061502782.1	None