Protein Alignment jbug and TRIM3

DIOPT Version :10

• Sequence 1: NP_001261140.1
• Gene: jbug / 43997
• FlyBaseID: FBgn0028371
• Length: 2990
• Species: Drosophila melanogaster
• Sequence 2: XP_047282213.1
• Gene: TRIM3 / 10612
• HGNCID: 10064
• Length: 827
• Species: Homo sapiens
• Alignment Length: 850
• Identity: 170/850 - (20%)
• Similarity: 273/850 - (32%)
• Gaps: 302/850 - (35%)

  Fly  1958 EGFDGVEPQIFVTSPSGDNEHCQLSQHDGGSYSASFRPTTVGRHLISVTANDQHINGSPFSCNVF 2022
            :|...::...|::|.....:......||           ....|.:||.|      |.|.||
Human   154 QGVSALQNNFFISSLMEAMQQAPDGAHD-----------PEDPHPLSVVA------GRPLSC--- 198

  Fly  2023 DVSRVSISGLEQQYGPANLGVPVTFSVDA--------AGAGE----GTLEL--VVSTDSSTVKAE 2073
                           |.:.|..:.|..:|        ..|||    ||:.|  ||....:.::.:
Human   199 ---------------PNHEGKTMEFYCEACETAMCGECRAGEHREHGTVLLRDVVEQHKAALQRQ 248

  Fly  2074 VVACARGLYDVTFVPQSTEPHYVNITFNEVAVDGSPFRVDIQQHTQHIQIGSLAAIDFPADD--- 2135
            :.| .||.     :||.:.         .:|:.|.     |.|..|..:..:||.|....:|
Human   249 LEA-VRGR-----LPQLSA---------AIALVGG-----ISQQLQERKAEALAQISAAFEDLEQ 293

  Fly  2136 -----------QIVEIFSPDQKSVPYSINRQTAEFRTHMTGNYTLRFIDRETRQHIGSRTLCVFD 2189
                       .:..|....||.:...::              ||    |:.::||||.  |.|.
Human   294 ALQQRKQALVSDLETICGAKQKVLQSQLD--------------TL----RQGQEHIGSS--CSFA 338

  Fly  2190 PTLVKITEVSEAFCHRPASIGVSLNEAGQGDLSALVRCGATEVPHTIRGPSKTGVYEIVYQPTRV 2254
            ...:::....|....|.     .:.|.    |:||......|.||      :....|:|.:   |
Human   339 EQALRLGSAPEVLLVRK-----HMRER----LAALAAQAFPERPH------ENAQLELVLE---V 385

  Fly  2255 APHKISILFNEVPISLKPLEINVLPASAGKEISVSGLGLYQSRVGKTTSFAIDT-------VKRP 2312
            ...:.|:|      :|..|   :..::...|...:|.||.|:.||:..|..:.|       |:..
Human   386 DGLRRSVL------NLGAL---LTTSATAHETVATGEGLRQALVGQPASLTVTTKDKDGRLVRTG 441

  Fly  2313 AREFDVVVSGPGGQALPVRCYQTKNGHLQAEFTINKPGQCVIEVLHQSKPLPGSPFTCESFDSSK 2377
            :.|....::||.|..|||.....|||..:..:|....|:.::.||...:|:.|||
Human   442 SAELRAEITGPDGTRLPVPVVDHKNGTYELVYTARTEGELLLSVLLYGQPVRGSP---------- 496

  Fly  2378 VSTQGVTKEPLALHSPNSFTVRTDNAGTAELEAFAISPSNQSIPVLISEQSDGVYNVEFVPSQPG 2442
                              |.||....|.       :.||...:...:..           |..||
Human   497 ------------------FRVRALRPGD-------LPPSPDDVKRRVKS-----------PGGPG 525

  Fly  2443 NYKLTLMYGGETIPSSPLNFTASSSGVRND--------ARAAGHGLEVCHRNKEASFVVYCPIAP 2499
            ::   :.......|||    ..|:.|.|.|        .|....|.|      :..|.
Human   526 SH---VRQKAVRRPSS----MYSTGGKRKDNPIEDELVFRVGSRGRE------KGEFT------- 570

  Fly  2500 NVQIERLDEYGERIEPKIKALGNNEWRISYTILSVGKYEIRASCPNRGSLPGS---PWHISCVES 2561
            |:|.......| ||   :.|..||:  ......:.|:::.|...  ||..||.   |..:: |::
Human   571 NLQGVSAASSG-RI---VVADSNNQ--CIQVFSNEGQFKFRFGV--RGRSPGQLQRPTGVA-VDT 626

  Fly  2562 NKVTPVGGWGTLV--DHDGRLILPARIIFDVE-----NAGPGKLVCSIDGIE-IPVDK-----LV 2613
            |        |.::  |:|.|.:    .||..|     ..|.|:|:    |.: :.||:     :|
Human   627 N--------GDIIVADYDNRWV----SIFSPEGKFKTKIGAGRLM----GPKGVAVDRNGHIIVV 675

  Fly  2614 DGKMCLNITGENLAAGEHDLDLTWSGLTITQCPRSAFV---TGQQAADKVQLMGRGLAAAQAGEA 2675
            |.|.|...|.:                     |....|   .|:.|.|:
Human   676 DNKSCCVFTFQ---------------------PNGKLVGRFGGRGATDR---------------- 703

  Fly  2676 AHFTIDASNAPAGRPEVILTSQDNTSLPVSLAQPRPSENIWLASYTPLKSTTGTLN----LSVKW 2736
             ||......|...:.|:::|...|.|:.|..|     :..:|..:.......|..|    ::|..
Human   704 -HFAGPHFVAVNNKNEIVVTDFHNHSVKVYSA-----DGEFLFKFGSHGEGNGQFNAPTGVAVDS 762

  Fly  2737 NGRLV 2741
            ||.::
Human   763 NGNII 767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jbug	NP_001261140.1	CH_jitterbug-like_rpt1	57..166	CDD:409076
		CH_jitterbug-like_rpt2	170..274	CDD:409078
		CH_jitterbug-like_rpt3	275..373	CDD:409034
		IG_FLMN	468..560	CDD:214720
		IG_FLMN	560..648	CDD:214720
		IG_FLMN	1119..1198	CDD:214720
		IG_FLMN	1220..1302	CDD:214720
		IG_FLMN	1310..1389	CDD:214720
		IG_FLMN	1399..1480	CDD:214720
		IG_FLMN	1480..1569	CDD:214720
		IG_FLMN	1575..1659	CDD:214720
		IG_FLMN	1661..1747	CDD:214720
		IG_FLMN	1757..1837	CDD:214720
		IG_FLMN	1837..1926	CDD:214720
		IG_FLMN	1936..2023	CDD:214720	13/64 (20%)
		Filamin	2021..2111	CDD:395505	19/103 (18%)
		IG_FLMN	2198..2280	CDD:214720	16/81 (20%)
		IG_FLMN	2285..2375	CDD:214720	28/96 (29%)
		IG_FLMN	2376..2465	CDD:214720	12/88 (14%)
		Filamin	2474..2555	CDD:395505	19/83 (23%)
		IG_FLMN	2657..2751	CDD:214720	16/88 (18%)
		IG_FLMN	2756..2847	CDD:214720
		IG_FLMN	2850..2944	CDD:214720
TRIM3	XP_047282213.1	RING-HC_TRIM3	99..146	CDD:438424
		Bbox2_TRIM3_C-VII	190..236	CDD:380883	16/69 (23%)
		BBC	241..367	CDD:128778	32/174 (18%)
		IG_FLMN	405..502	CDD:214720	31/124 (25%)
		NHL_TRIM2_like	554..827	CDD:271330	59/294 (20%)
		NHL repeat	572..611	CDD:271330	10/46 (22%)
		NHL repeat	619..658	CDD:271330	12/51 (24%)
		NHL repeat	661..698	CDD:271330	9/57 (16%)
		NHL repeat	705..746	CDD:271330	9/45 (20%)
		NHL repeat	752..794	CDD:271330	4/15 (27%)
		NHL repeat	797..823	CDD:271330