DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pten and DNAJC6

DIOPT Version :9

Sequence 1:	NP_001162933.1	Gene:	Pten / 43991	FlyBaseID:	FBgn0026379	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_001243793.1	Gene:	DNAJC6 / 9829	HGNCID:	15469	Length:	970	Species:	Homo sapiens

Alignment Length:	363	Identity:	92/363 - (25%)
Similarity:	161/363 - (44%)	Gaps:	63/363 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SNVIRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHY 73
            |.||::|.|      ..|| |||.||:...||.|.:|. |.::..|||:::|:...|:..|..||
Human   107 SRVIQSVTS------YTKG-DLDFTYVTSRIIVMSFPL-DNVDIGFRNQVDDIRSFLDSRHLDHY 163

  Fly    74 KIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGR 138
            .:||| |.:||..|||..||:...:.....|::..:...|.::..||.::..||..|||..|:..
Human   164 TVYNL-SPKSYRTAKFHSRVSECSWPIRQAPSLHNLFAVCRNMYNWLLQNPKNVCVVHCLDGRAA 227

  Fly   139 TGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTI-PSQRRYVQYFSKLVCSS------VPY 196
            :..::.|..:|..:..:...|:.....|    |.|:.: ||.|||:.|...|:...      .|.
Human   228 SSILVGAMFIFCNLYSTPGPAIRLLYAK----RPGIGLSPSHRRYLGYMCDLLADKPYRPHFKPL 288

  Fly   197 SKVSLNVCEIRFSESSCVQNLGMVECSISV----LHDSATENAKPDRLKTLPIDFQKSFV---LT 254
            :..|:.|..|.|....  :|.....|.:.:    ::.:.|:.   :|:|...:...|.|:   :|
Human   289 TIKSITVSPIPFFNKQ--RNGCRPYCDVLIGETKIYSTCTDF---ERMKEYRVQDGKIFIPLNIT 348

  Fly   255 IKPSIPVS-----GDVKFELTKKSPDKIICHFWLNTFFVRNYSPCESDGTVNKYIHTLSKSEID- 313
            ::..:.||     ..:...|..|..:..|.....:|.|:      ..|.||.|:    :|.|:|
Human   349 VQGDVVVSMYHLRSTIGSRLQAKVTNTQIFQLQFHTGFI------PLDTTVLKF----TKPELDA 403

  Fly   314 -DVHKDSEHKRFSEEFKISIVFEAENFSNDVQAEASEK 350
             ||     .:::.:.|::::         ||:.:..:|
Human   404 CDV-----PEKYPQLFQVTL---------DVELQPHDK 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	29/108 (27%)
Pten	NP_001162933.1	PTEN_C2	196..335	CDD:287393	29/152 (19%)
DNAJC6	NP_001243793.1	PTEN_C2	283..421	CDD:313607	31/166 (19%)
		Atrophin-1	<562..829	CDD:331285
		DnaJ	<918..963	CDD:99751
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810