DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pten and AFH14

DIOPT Version :9

Sequence 1:	NP_001162933.1	Gene:	Pten / 43991	FlyBaseID:	FBgn0026379	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_001321171.1	Gene:	AFH14 / 840068	AraportID:	AT1G31810	Length:	1230	Species:	Arabidopsis thaliana

Alignment Length:	481	Identity:	105/481 - (21%)
Similarity:	174/481 - (36%)	Gaps:	147/481 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHYKIYN-------------LCSER 82
            |..|:.|:.......| |.|..:|.:  |.:..|.||.....:..:|             ||
plant    21 DRVYVFDSCFCTEVLA-DSLYQIFLH--EVINDLHEEFPESSFLAFNFREGEKKSVFAETLC--- 79

  Fly    83 SYDVAKFRGRVAVYPFDDHNPP--TIELIQRFCSDVDMWL-KEDSSNVVAVHC-KAGKGRTGTMI 143
            .|||.     |..||......|  .:.|||.|....:.|| :.:..:|:.:|| :.|......::
plant    80 EYDVT-----VLEYPRQYEGCPMLPLSLIQHFLRVCESWLARGNRQDVILLHCERGGWPLLAFIL 139

  Fly   144 CAYLVFSGIKKSADEALAWYDEKRTKD------RKGV--------TIPSQRRYVQYFSKLVCSS- 193
            .::|:|..:...         |:||.:      .||:        ..|||.||:||.::...:|
plant   140 ASFLIFRKVHSG---------ERRTLEIVHREAPKGLLQLLSPLNPFPSQLRYLQYVARRNINSE 195

  Fly   194 --VPYSKVSLNVCEIR-----FSESSC---VQNLGMVECSISVLHD----SATENAKPDRLKTLP 244
              .|...:||:...||     .|:..|   ::..|....|.|.|..    |.::..||.|
plant   196 WPPPERALSLDCVIIRGIPNFDSQHGCRPIIRIFGRNYSSKSGLSTEMVYSMSDKKKPLR----- 255

  Fly   245 IDFQKSFVLTIKPSIP--VSGDVKFELTKK--SPDKIICHF--WLNTFFVRNYSPCESDGTVNKY 303
             .::::....||..|.  |.|||..|....  .|::.:..|  ..||.|:|:            .
plant   256 -HYRQAECDVIKIDIQCWVQGDVVLECVHMDLDPEREVMMFRVMFNTAFIRS------------N 307

  Fly   304 IHTLSKSEIDDVHKDSEHKRFSEEFKISIVF-EAENFSNDVQAEASEKERNENVLNFERSDYDSL 367
            |..|:...:|.:.:..:|  :.:.|:..::| |.||.|
plant   308 ILMLNSDNLDILWEAKDH--YPKGFRAEVLFGEVENAS--------------------------- 343

  Fly   368 SPNCYAEKKVLTAIVNDNTTKSQTIETLDHKDIVTKIQ-----YDTSTNSKNTSTACKRKQPNSK 427
                  .:||.|.|||.:.|....||..      :::|     .|.:.|..:.:....::
plant   344 ------PQKVPTPIVNGDETGGLPIEAF------SRVQELFSGVDLAENGDDAALWLLKQ----- 391

  Fly   428 TLLPSLNDS---TKEEIKRNHIFNQP 450
              |.::||:   |:...|.:..||.|
plant   392 --LAAINDAKEFTRFRHKGSFYFNSP 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	27/125 (22%)
Pten	NP_001162933.1	PTEN_C2	196..335	CDD:287393	34/157 (22%)
AFH14	NP_001321171.1	PTEN_C2	198..338	CDD:287393	35/159 (22%)
AFH14	NP_001321171.1	FH2	814..1181	CDD:280362
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910