DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pten and AT5G58160

DIOPT Version :9

Sequence 1:	NP_001162933.1	Gene:	Pten / 43991	FlyBaseID:	FBgn0026379	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_001318825.1	Gene:	AT5G58160 / 835928	AraportID:	AT5G58160	Length:	1266	Species:	Arabidopsis thaliana

Alignment Length:	541	Identity:	112/541 - (20%)
Similarity:	188/541 - (34%)	Gaps:	150/541 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 EENHAQHYKIY-----NLCSE-----------------RSY--DVAKFRG-RVAVYP--FDDHNP 103
            |||    ||:|     |...|                 ||.  ||....| .:..||  ::..:.
plant    37 EEN----YKVYMAGVVNQLQEHFPEASSLVFNFREVGTRSVMADVLSEHGLTIMDYPRHYEGCSL 97

  Fly   104 PTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRT-GTMICAYLV----FSGIKKSAD------ 157
            ..:|::..|....:.||....:|::.:||::|.... ..|:.|.|:    :||..|:.|
plant    98 LPVEVMHHFLRSSESWLSLGPNNLLLMHCESGAWPVLAFMLAALLIYRKQYSGESKTLDMIYKQA 162

  Fly   158 --EALAWYDEKRTKDRKGVTIPSQRRYVQYFSK--LVCSSVPYSKVSLNVCEI-RFSESSCVQNL 217
              |.|..:....       .||||.||:||.|:  ||....|..:.....|.| ||...  |...
plant   163 PRELLRLFSPLN-------PIPSQLRYLQYVSRRNLVSEWPPLDRALTMDCVILRFIPD--VSGQ 218

  Fly   218 GMVECSISVLHDSA--TENAKPDRLKTLPID------FQKSFVLTIKPSI--PVSGDVKFELTKK 272
            |.......:.....  .::.||..|.|.|..      ::::....:|..|  .|.||:..|....
plant   219 GGFRPMFRIYGQDPFFVDDKKPKLLYTTPKKGKHLRVYKQAECELVKIDINCHVQGDIVIECLSL 283

  Fly   273 SPDK----IICHFWLNTFFVRNYSPCESDGTVNKYIHTLSKSEIDDVHKDSEH-KRFSEEFKISI 332
            :.|.    ::.....||.|:|:            .|..|::.|:|.:.    | |.|.:.|::.:
plant   284 NDDMEREVMMFRVVFNTAFIRS------------NILMLNRDEVDTLW----HIKEFPKGFRVEL 332

  Fly   333 VFEAENFSNDVQAEASEKERNENVLNFER-SDYDSLSPNCYAEKKVLTAIVN--DNTTKSQTIET 394
            :|      :|:.|.:|     .:::||.. .:.|.|....:::.......|:  |.|..::.:
plant   333 LF------SDMDAASS-----VDLMNFSSLEEKDGLPIEVFSKVHEFFNQVDWVDQTDATRNM-- 384

  Fly   395 LDHKDIVTKIQYDTSTNSKNTSTACKRKQPNSKTLLP-SLNDSTKEEIKRN------------HI 446
            .....|...:|.....||          .|..:.|.| |::|..|.....|            ..
plant   385 FQQLAIANAVQEGLDGNS----------SPRLQGLSPKSIHDIMKHAAIENSAKFKLSSMSEVET 439

  Fly   447 FNQPSIKKTDLIKWQNSEVHITSDTRSI----NENKNINYNSYITCKQSSPKFNC---------- 497
            .:.|....||.:|     ..|..|..|:    |:.:|.:.::.....|.||....
plant   440 IDTPEKPPTDSVK-----KFIAEDVHSVLQINNQEQNASEDATKLLHQESPSLKLVHHSATVKPL 499

  Fly   498 -----GTEDGEEDWESGESTY 513
                 ..|:.||::....|.:
plant   500 VDDSKSPENAEENFPKSPSAH 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	32/140 (23%)
Pten	NP_001162933.1	PTEN_C2	196..335	CDD:287393	30/154 (19%)
AT5G58160	NP_001318825.1	PTP_PTEN-like	16..189	CDD:350347	41/162 (25%)
		PTEN_C2	197..336	CDD:402161	32/162 (20%)
		FH2	835..1201	CDD:396655
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910