DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pten and PEN3

DIOPT Version :9

Sequence 1:	NP_001162933.1	Gene:	Pten / 43991	FlyBaseID:	FBgn0026379	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_566929.1	Gene:	PEN3 / 824173	AraportID:	AT3G50110	Length:	632	Species:	Arabidopsis thaliana

Alignment Length:	550	Identity:	162/550 - (29%)
Similarity:	244/550 - (44%)	Gaps:	137/550 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ISLMSNVIRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPD-------KLEGLFRNRLEDVF 62
            :..|....|::||:.:.||:|..:|||:|||.:||||||:||.|       ..|||:||.:|:|.
plant   173 VKAMQVKARHIVSQNKRRYQEGEFDLDMTYITENIIAMGFPAGDISSGLFGFFEGLYRNHMEEVI 237

  Fly    63 KLLEENHAQHYKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNV 127
            |..|.:|...||:|||||||.||.::|.|:||.:||||||.|.|:||..||.....|||||..||
plant   238 KFFETHHKDKYKVYNLCSERLYDASRFEGKVASFPFDDHNCPPIQLIPSFCQSAYTWLKEDIQNV 302

  Fly   128 VAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKL--- 189
            |.||||||..|||.|||..|::.....:|:||:.:|::||..|.|.:.:|||.|||:|:.::
plant   303 VVVHCKAGMARTGLMICCLLLYLKFFPTAEEAIDYYNQKRCLDGKALVLPSQIRYVKYYERVQNQ 367

  Fly   190 VCSSVPYSKVSLNVCEIRFSESSC-VQNLGMVEC--------SISVLHDSATENAKPDRLKTL-P 244
            ....||             .|..| ::...::.|        :||...|......|..:.|.| |
plant   368 FDGKVP-------------PERRCMLRGFRLINCPYWIRPAITISNHTDILFSTKKHQKTKDLGP 419

  Fly   245 IDF-----QKSFVLTIKPS----IPVSGDVKFELTKKSPDKIICHFWLNTFFVRNYSPCESDGTV 300
            .||     :|..|:...|.    ..::||.|........| ..|  ||||....|.:
plant   420 EDFWIKAPKKGVVVFAIPGEAGLTELAGDFKIHFQDSDGD-FYC--WLNTTLTDNRT-------- 473

  Fly   301 NKYIHTLSKSEIDDVHKDSEHKRFSEEFKISIVF---------EAENFSNDVQAEASEKERNENV 356
                 .|..|:.|...|   .|..:..|.:.||.         ::::.|...|:::|....:..:
plant   474 -----MLKGSDFDGFDK---RKLPAPGFHVEIVMIEPDNSQPTKSKSDSTQQQSQSSSSADSSKL 530

  Fly   357 LNFERSDYDSLSPNCYAEKKVLTAIVNDNTTKSQTIETLDHKDIVTKIQYDTSTNSKNTSTACKR 421
            .:.|:.|                                   |:.:....:...||::.||
plant   531 KSNEKDD-----------------------------------DVFSDSDGEEEGNSQSYST---- 556

  Fly   422 KQPNSKTLLPSLNDSTKEEIKRNHIFNQPSIKKTD-----LIKWQNSEVH---ITSDTRSINENK 478
               |.||.      |:.....:.|..|:|. |:.|     .:...:|..|   |.:::.::::.|
plant   557 ---NEKTA------SSMHTTSKPHQINEPP-KRDDPSANRSVTSSSSSGHYNPIPNNSLAVSDIK 611

  Fly   479 NINYNSYITCKQSSPKFNCGTEDGEEDWES 508
            .|..::.:        |:.|  |.|||:||
plant   612 AIAADASV--------FSFG--DEEEDYES 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	57/108 (53%)
Pten	NP_001162933.1	PTEN_C2	196..335	CDD:287393	33/166 (20%)
PEN3	NP_566929.1	PTPc	<247..363	CDD:304379	63/115 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	50	1.000	Domainoid score	I4381
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001369
OrthoInspector	1	1.000	-	-		otm2905
orthoMCL	1	0.900	-	-		OOG6_100936
Panther	1	1.100	-	-	O	PTHR12305
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X965
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.810