DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pten and Gak

DIOPT Version :9

Sequence 1:	NP_001162933.1	Gene:	Pten / 43991	FlyBaseID:	FBgn0026379	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_112292.1	Gene:	Gak / 81659	RGDID:	621589	Length:	1305	Species:	Rattus norvegicus

Alignment Length:	466	Identity:	120/466 - (25%)
Similarity:	197/466 - (42%)	Gaps:	90/466 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SNVIRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHY 73
            |.||::|.:      ..|| |||::||...|..|.:|| :.:|...:|.:|||...|:..|..||
  Rat   392 SKVIQSVAN------YAKG-DLDISYITSRIAVMSFPA-EGVESAIKNNIEDVRLFLDAKHPGHY 448

  Fly    74 KIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGR 138
            .:||| |.|.|..:||..||....:.....|.:..:...|..:..||:||..||..|||..|:..
  Rat   449 AVYNL-SPRIYRASKFHNRVTECGWAVRRAPHLHSLYTLCRSMHAWLREDHRNVCVVHCMDGRAA 512

  Fly   139 TGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSS--VPYSKVSL 201
            :...:||:|.|..:..:|:.|:..:..||..  .|:. ||.:||::|...:|...  .|:||..|
  Rat   513 SAVAVCAFLCFCRLFSTAEAAVYMFSMKRCP--PGIW-PSHKRYIEYVCDMVAEEPITPHSKPML 574

  Fly   202 NVCEIR-----FSESSCVQNLGMVECSISVLHDSATENAKP-DRLKTLPIDFQKSFVLTIKPSIP 260
            ....:.     ||:.   :|.....|.:.|..:..|..::. ||:|...|:..|:   .|...|.
  Rat   575 VKSVVMTPVPLFSKQ---RNGCRPFCEVYVGEERVTTTSQEYDRMKEFKIEDGKA---VIPLGIT 633

  Fly   261 VSGDVKF-----------ELTKKSPDKIICHFWLNTFFV-RNYSPCESDGTVNKYIHTLSKSEID 313
            |.|||..           .|..|.....:.....:|.|| ||       .|..|:    :|.::|
  Rat   634 VQGDVLTIIYHARSTLGGRLQAKMASMKMFQIQFHTGFVPRN-------ATTVKF----AKYDLD 687

  Fly   314 --DVHKDSEHKRFSEEFKISIVFEAE---NFSNDV-------------QAEASEKERNENVLN-F 359
              |:     .:::.:.|::::..|.|   ..|.||             :...|.:|..:::|: |
  Rat   688 ACDI-----QEKYPDLFQVNLEVEVEPRDRPSRDVPPWENTSLRGLNPKILFSNREEQQDILSKF 747

  Fly   360 ER----------SDYDSLSPNCYAEKKVLTAIVNDNTTKSQTIETLDHKDIVTKIQYDTSTNSKN 414
            .:          :.||:.:.:..||.....:..:.:|..:..:.|||.::     :.|..|...|
  Rat   748 GKPELPRQPGSTAQYDAEAGSPEAEITESDSPQSSSTDTNHFLHTLDWQE-----EKDPETGVDN 807

  Fly   415 TSTACKRKQPN 425
            ||.  |..|.|
  Rat   808 TSP--KESQSN 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	35/108 (32%)
Pten	NP_001162933.1	PTEN_C2	196..335	CDD:287393	33/158 (21%)
Gak	NP_112292.1	STKc_GAK	39..320	CDD:270938
		S_TKc	41..311	CDD:214567
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..354
		PTEN_C2	568..706	CDD:287393	34/159 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	747..856		17/77 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1044..1141
		DnaJ	<1253..1298	CDD:99751
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810