DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pten and tns2a

DIOPT Version :9

Sequence 1:	NP_001162933.1	Gene:	Pten / 43991	FlyBaseID:	FBgn0026379	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	XP_001921043.3	Gene:	tns2a / 799109	ZFINID:	ZDB-GENE-090312-163	Length:	1616	Species:	Danio rerio

Alignment Length:	471	Identity:	119/471 - (25%)
Similarity:	200/471 - (42%)	Gaps:	97/471 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANTISLMSNVIRNVV----SKKRI--RYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLE 59
            :.:|.||.....||.:    |..|:  |..|:.||.|||||.:.||::.:| |...|..:|..|.
Zfish   112 LGSTKSLTYTKQRNTLPRSFSVDRVMDRVMERHYDFDLTYITERIISVFFP-PLLEEQRYRLNLR 175

  Fly    60 DVFKLLEENHAQHYKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDS 124
            :|..:|:..|...:.:.|| |||.:|:.:...:|..:.:.|.:.|.::.|...|..::.||..|.
Zfish   176 EVAAMLKSKHQDKFLLLNL-SERRHDITRLNPKVHDFGWPDMHSPPLDKICAMCKAMENWLNSDP 239

  Fly   125 SNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYD-EKRTKDRKGVTI-PSQRRYVQYFS 187
            .:||.:|||..||:||.:|.||:.:|.|...||:||:... .|..:|:...:: |||.||:|||.
Zfish   240 QHVVVLHCKGNKGKTGVIIAAYMHYSKISAGADQALSTLAMRKFCEDKVASSLQPSQNRYIQYFG 304

  Fly   188 KLVCSSVPYSKVSLNVCEI------RFSES-------SCVQNLGMVECS-ISVLHDSATENAKPD 238
            .|:..|:..:...|.:.::      .|.|.       ...|::.:|..| |..|..||:
Zfish   305 GLLSGSIKMNSSPLFLHQVLIPTIPNFQEDDGFFPFLKIYQSMQLVYTSGIYDLQGSAS------ 363

  Fly   239 RLKTLPIDFQKSFVLTIKPSIPVSGDVKFELTKKSPDKIICHFWLNTFFVRNYSPCESDGTVNKY 303
                      :..::||:|::.:.||:          .:.|:.       |.....|.|......
Zfish   364 ----------RRLIITIEPALLLKGDI----------MVKCYH-------RRVESAERDSVFRLQ 401

  Fly   304 IHT---------LSKSEIDDVHKDSEHKRFSEEFKISIVFEAENFSNDVQAEASEKERNENVLNF 359
            .||         ..|.|:|:...|.   :|..:..:..||.    |...:.:....:||:..::.
Zfish   402 FHTCTVHAAQLWFGKGELDEACSDD---KFPPDAIVEFVFS----SGPEKIKGRVSQRNDPAVSV 459

  Fly   360 ERSDYDSLSP----NCYAEKKVLTAIVNDNTTKSQTIETLDHKDIVTKIQYDTSTNSKNTSTACK 420
               ||::..|    :.|.         |.|.....::|.:.|    |:...|.|..::    ..|
Zfish   460 ---DYNTNDPVVRWDSYE---------NFNQRHQDSLEDIAH----TRGPVDGSLYAQ----VKK 504

  Fly   421 RKQPNSKTLLPSLNDS 436
            |:.....:.|||.|.|
Zfish   505 RRAAAGCSSLPSTNGS 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	36/109 (33%)
Pten	NP_001162933.1	PTEN_C2	196..335	CDD:287393	27/161 (17%)
tns2a	XP_001921043.3	C1	45..91	CDD:237996
		PTPc_motif	205..325	CDD:214649	39/119 (33%)
		PTEN_C2	313..440	CDD:313607	28/166 (17%)
		Atrophin-1	<903..1322	CDD:331285
		SH2_Tensin_like	1340..1455	CDD:198181
		PTB_tensin	1479..1611	CDD:269924
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910