DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pten and Dnajc6

DIOPT Version :9

Sequence 1:	NP_001162933.1	Gene:	Pten / 43991	FlyBaseID:	FBgn0026379	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_001158055.1	Gene:	Dnajc6 / 72685	MGIID:	1919935	Length:	968	Species:	Mus musculus

Alignment Length:	521	Identity:	115/521 - (22%)
Similarity:	210/521 - (40%)	Gaps:	127/521 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SNVIRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHY 73
            |.||::|.|      ..|| |||.||:...||.|.:|. |.::..|||:::|:...|:..|..||
Mouse   105 SRVIQSVSS------YTKG-DLDFTYVTSRIIVMSFPV-DSVDIGFRNQVDDIRSFLDSRHLDHY 161

  Fly    74 KIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGR 138
            .:||| |.:||..|||..||:...:.....|::..:...|.::..||.::..||..|||..|:..
Mouse   162 TVYNL-SPKSYRTAKFHSRVSECSWPIRQAPSLHNLFAVCRNMYNWLLQNPKNVCVVHCLDGRAA 225

  Fly   139 TGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTI-PSQRRYVQYFSKLVC----------- 191
            :..::.|..:|..:..:...|:.....|    |.|:.: ||.|||:.|...|:.
Mouse   226 SSILVGAMFIFCNLYSTPGPAVRLLYAK----RPGIGLSPSHRRYLGYMCDLLADKPYRPHFKPL 286

  Fly   192 -------SSVPYSKVSLN----VCEIRFSESSCVQNLGMVECSISVLHDSATENAKPDRLKTLPI 245
                   |.||:.....|    .|::...|:.              ::.:.|:.   :|:|...:
Mouse   287 TIKAITVSPVPFFNKQRNGCRPYCDVLIGETK--------------IYSTCTDF---ERMKEYRV 334

  Fly   246 DFQKSFV---LTIKPSIPVS-----GDVKFELTKKSPDKIICHFWLNTFFVRNYSPCESDGTVNK 302
            ...|.|:   :|::..:.||     ..:...|..|..:..|.....::.|:      ..|.||.|
Mouse   335 QDGKIFIPLNITVQGDVIVSMYHLRSTIGSRLQAKVTNTQIFQLQFHSGFI------PLDTTVLK 393

  Fly   303 YIHTLSKSEID--DVHKDSEHKRFSEEFKISIVFEA-------------ENF-SNDVQAE---AS 348
            :    :|.|:|  ||     .:::.:.|::::..|.             |:: :.||...   :|
Mouse   394 F----TKPELDACDV-----PEKYPQLFQVTLDIEVQPQDKVIDLTPPWEHYCTKDVNPSILFSS 449

  Fly   349 EKERNENVLNFERSDYDSLSPN--------------CYAEKKVLTAIVNDNTTKSQTIETLDHKD 399
            ::|..:.:....::..| |.|:              |:.::|         :.||:..|  ||..
Mouse   450 QQEHQDTLALGGQAPAD-LPPDHPRNLGQGGFFASLCWQDQK---------SEKSRCEE--DHAA 502

  Fly   400 IVTKIQYDTSTNSKNTSTACKRKQPNSKTLLPSLNDSTKEEIKRNHIFNQPSIKKTDLIKWQNSE 464
            :|.:    .|..|.:..........|::...|  :.:.|...|:......|..::.||:..:.|:
Mouse   503 LVNQ----ESEQSDDELLTLSSPHGNAEGDKP--HGAKKPGKKQQEPAAPPPPEEVDLLGLEGSD 561

  Fly   465 V 465
            |
Mouse   562 V 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	29/108 (27%)
Pten	NP_001162933.1	PTEN_C2	196..335	CDD:287393	25/152 (16%)
Dnajc6	NP_001158055.1	PTEN_C2	281..419	CDD:287393	28/169 (17%)
Dnajc6	NP_001158055.1	DnaJ	<916..961	CDD:99751
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810