DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pten and TPTE

DIOPT Version :9

Sequence 1:	NP_001162933.1	Gene:	Pten / 43991	FlyBaseID:	FBgn0026379	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_954870.3	Gene:	TPTE / 7179	HGNCID:	12023	Length:	551	Species:	Homo sapiens

Alignment Length:	367	Identity:	115/367 - (31%)
Similarity:	192/367 - (52%)	Gaps:	62/367 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MSNVIRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQH 72
            :..:||..||:.:.||...|:||||||:.:.||||.:|:..: :..:||.:::|.:.|::.|..|
Human   215 LEKLIRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGR-QSFYRNPIKEVVRFLDKKHRNH 278

  Fly    73 YKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKG 137
            |::|||||||:||...|..||.....||||.||:..:..|..:|:.|:.:|..|:||:|||.|..
Human   279 YRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTD 343

  Fly   138 RTGTMICAYLVFSGIKKSADEALAWYDEKRTKDR------KGVTIPSQRRYVQYFSKL------- 189
            |||||:||:|:.|.|..:|.|:|.::.|:|| |:      :||..|||:|||.||:::
Human   344 RTGTMVCAFLIASEICSTAKESLYYFGERRT-DKTHSEKFQGVKTPSQKRYVAYFAQVKHLYNWN 407

  Fly   190 ------------VCSSVPYSKVSLNVCEIRFSESSCVQNLGMVECSISVLHDSATENAKPDRLKT 242
                        :..|:|.....|.: :|...:......:.:.:||:       .:|...|::
Human   408 LPPRRILFIKHFIIYSIPRYVRDLKI-QIEMEKKVVFSTISLGKCSV-------LDNITTDKI-- 462

  Fly   243 LPIDFQKSFVLTIKPSIPVSGDVKFELTKKS-P---DKIICHFWLNTFFVRNYSPCESDGTVNKY 303
                     ::.:...:|:..|||.:....: |   |....:|||:|.|:.|          |:.
Human   463 ---------LIDVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWLHTSFIEN----------NRL 508

  Fly   304 IHTLSKSEIDDVHKDSEHKRFSEEFKISIVFEAENFSNDVQA 345
            .  |.|:|:|::||....:.:..:|.:.|:|..:..|:||.|
Human   509 Y--LPKNELDNLHKQKARRIYPSDFAVEILFGEKMTSSDVVA 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	48/108 (44%)
Pten	NP_001162933.1	PTEN_C2	196..335	CDD:287393	27/142 (19%)
TPTE	NP_954870.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		PTP_VSP_TPTE	224..400	CDD:350360	78/177 (44%)
		PTEN_C2	409..539	CDD:402161	30/160 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	80	1.000	Domainoid score	I8613
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001369
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100936
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X965
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.710