Protein Alignment Pten and TNS1

DIOPT Version :10

• Sequence 1: NP_477422.2
• Gene: Pten / 43991
• FlyBaseID: FBgn0026379
• Length: 514
• Species: Drosophila melanogaster
• Sequence 2: XP_047301592.1
• Gene: TNS1 / 7145
• HGNCID: 11973
• Length: 2111
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 137/550 - (24%)
• Similarity: 215/550 - (39%)
• Gaps: 151/550 - (27%)

  Fly    12 IRNV-VSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHYKI 75
            |||: ||    |..|...:|||.|:.:.|||:.:|:....|. ||:.|.:|.::|:..|..:|.:
Human   229 IRNMSVS----RTMEDSCELDLVYVTERIIAVSFPSTANEEN-FRSNLREVAQMLKSKHGGNYLL 288

  Fly    76 YNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTG 140
            :|| |||..|:.|...:|..:.:.|.:.|.:|.|...|..:|.||..|..|||.:|.|..:||.|
Human   289 FNL-SERRPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWLNADPHNVVVLHNKGNRGRIG 352

  Fly   141 TMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTI--PSQRRYVQYFSKLVCSSVPYSKVSLNV 203
            .:|.||:.:|.|..|||:||..:..||..:.|.|.|  |||||||.|||.|:..|:..:...|.:
Human   353 VVIAAYMHYSNISASADQALDRFAMKRFYEDKIVPIGQPSQRRYVHYFSGLLSGSIKMNNKPLFL 417

  Fly   204 CEIRF-------SESSCVQNLGMVECSISVLHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIPV 261
            ..:..       |:..|...|.:.: ::..::.|...|        :|.|.|.|..:||:|.:.:
Human   418 HHVIMHGIPNFESKGGCRPFLRIYQ-AMQPVYTSGIYN--------IPGDSQTSVCITIEPGLLL 473

  Fly   262 SGDVKFELTKK---SPDKIICHFWLNTFFVRNYSPCESDGTVNKYIHTL----SKSEIDDVHKDS 319
            .||:..:...|   ||.:       :..|...:..|.        ||.|    .|.::||..||.
Human   474 KGDILLKCYHKKFRSPAR-------DVIFRVQFHTCA--------IHDLGVVFGKEDLDDAFKDD 523

  Fly   320 EHKRFSEEFKISIVFE--------AENFSN----DVQAEASEK------------ERNENVLNFE 360
               ||.|..|:..||.        .|:..|    .|....|:.            .|::.:....
Human   524 ---RFPEYGKVEFVFSYGPEKIQGMEHLENGPSVSVDYNTSDPLIRWDSYDNFSGHRDDGMEGAV 585

  Fly   361 RSDYD----------------SLSPNC-------------------------------------- 371
            |||:|                |||.:|
Human   586 RSDFDMKAQSFSALSFFPAFLSLSAHCLRTFEKQMGAPHVMQRQKGPRVVPWLLSAMQACASWFG 650

  Fly   372 ------------------YAEKKVLTAIVND----NTTKSQTIETLDHKDIVTKIQYDTSTNSKN 414
                              ||:.|...::...    |.|:.....|.:|.:....:..|:..::.:
Human   651 GLCIKVVGHTQGPLDGSLYAKVKKKDSLHGSTGAVNATRPTLSATPNHVEHTLSVSSDSGNSTAS 715

  Fly   415 TST-ACKRKQPNSKTLLPSLNDSTKEEIKR 443
            |.| ......|.:.:...:|:...|.|:.|
Human   716 TKTDKTDEPVPGASSATAALSPQEKRELDR 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_477422.2	PTP_PTEN	31..189	CDD:350359	65/159 (41%)
		PTEN_C2	196..335	CDD:463081	33/152 (22%)
TNS1	XP_047301592.1	C1	37..123	CDD:412127
		PTP_tensin-1	245..403	CDD:350408	65/159 (41%)
		PTEN_C2	410..536	CDD:463081	33/152 (22%)
		PHA03247	<858..1273	CDD:223021
		PHA03247	<1367..1766	CDD:223021
		SH2_Tensin_like	1835..1950	CDD:198181
		PTB_tensin	1972..2105	CDD:269924