Protein Alignment Pten and TNS1

DIOPT Version :9

• Sequence 1: NP_001162933.1
• Gene: Pten / 43991
• FlyBaseID: FBgn0026379
• Length: 514
• Species: Drosophila melanogaster
• Sequence 2: XP_024308847.1
• Gene: TNS1 / 7145
• HGNCID: 11973
• Length: 2005
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 137/550 - (24%)
• Similarity: 215/550 - (39%)
• Gaps: 151/550 - (27%)

  Fly    12 IRNV-VSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHYKI 75
            |||: ||    |..|...:|||.|:.:.|||:.:|:....|. ||:.|.:|.::|:..|..:|.:
Human   123 IRNMSVS----RTMEDSCELDLVYVTERIIAVSFPSTANEEN-FRSNLREVAQMLKSKHGGNYLL 182

  Fly    76 YNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTG 140
            :|| |||..|:.|...:|..:.:.|.:.|.:|.|...|..:|.||..|..|||.:|.|..:||.|
Human   183 FNL-SERRPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWLNADPHNVVVLHNKGNRGRIG 246

  Fly   141 TMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTI--PSQRRYVQYFSKLVCSSVPYSKVSLNV 203
            .:|.||:.:|.|..|||:||..:..||..:.|.|.|  |||||||.|||.|:..|:..:...|.:
Human   247 VVIAAYMHYSNISASADQALDRFAMKRFYEDKIVPIGQPSQRRYVHYFSGLLSGSIKMNNKPLFL 311

  Fly   204 CEIRF-------SESSCVQNLGMVECSISVLHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIPV 261
            ..:..       |:..|...|.:.: ::..::.|...|        :|.|.|.|..:||:|.:.:
Human   312 HHVIMHGIPNFESKGGCRPFLRIYQ-AMQPVYTSGIYN--------IPGDSQTSVCITIEPGLLL 367

  Fly   262 SGDVKFELTKK---SPDKIICHFWLNTFFVRNYSPCESDGTVNKYIHTL----SKSEIDDVHKDS 319
            .||:..:...|   ||.:       :..|...:..|.        ||.|    .|.::||..||.
Human   368 KGDILLKCYHKKFRSPAR-------DVIFRVQFHTCA--------IHDLGVVFGKEDLDDAFKDD 417

  Fly   320 EHKRFSEEFKISIVFE--------AENFSN----DVQAEASEK------------ERNENVLNFE 360
               ||.|..|:..||.        .|:..|    .|....|:.            .|::.:....
Human   418 ---RFPEYGKVEFVFSYGPEKIQGMEHLENGPSVSVDYNTSDPLIRWDSYDNFSGHRDDGMEGAV 479

  Fly   361 RSDYD----------------SLSPNC-------------------------------------- 371
            |||:|                |||.:|
Human   480 RSDFDMKAQSFSALSFFPAFLSLSAHCLRTFEKQMGAPHVMQRQKGPRVVPWLLSAMQACASWFG 544

  Fly   372 ------------------YAEKKVLTAIVND----NTTKSQTIETLDHKDIVTKIQYDTSTNSKN 414
                              ||:.|...::...    |.|:.....|.:|.:....:..|:..::.:
Human   545 GLCIKVVGHTQGPLDGSLYAKVKKKDSLHGSTGAVNATRPTLSATPNHVEHTLSVSSDSGNSTAS 609

  Fly   415 TST-ACKRKQPNSKTLLPSLNDSTKEEIKR 443
            |.| ......|.:.:...:|:...|.|:.|
Human   610 TKTDKTDEPVPGASSATAALSPQEKRELDR 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	40/108 (37%)
		PTEN_C2	196..335	CDD:287393	33/152 (22%)
TNS1	XP_024308847.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810