Protein Alignment Pten and TNS3

DIOPT Version :10

• Sequence 1: NP_477422.2
• Gene: Pten / 43991
• FlyBaseID: FBgn0026379
• Length: 514
• Species: Drosophila melanogaster
• Sequence 2: XP_047276679.1
• Gene: TNS3 / 64759
• HGNCID: 21616
• Length: 1575
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 133/562 - (23%)
• Similarity: 234/562 - (41%)
• Gaps: 123/562 - (21%)

  Fly    25 EKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKF 89
            |:|:.||||||.:.|||:.:||....|....| |::|.::|:..|..:|.:.|| ||:.||:.|.
Human   132 EEGHGLDLTYITERIIAVSFPAGCSEESYLHN-LQEVTRMLKSKHGDNYLVLNL-SEKRYDLTKL 194

  Fly    90 RGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKK 154
            ..::....:.:.:.|.::.:...|...:.||..:..:||.:||:.||||.|.:|.:|:.|:.:..
Human   195 NPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNLQHVVVIHCRGGKGRIGVVISSYMHFTNVSA 259

  Fly   155 SADEALAWYDEKRTKDRK--GVTIPSQRRYVQYFSKLVCSSVPYSKVSLNVCEIRF--------- 208
            |||:||..:..|:..|.|  .:..|||:||||:.|.|:..||   |::.:...:.|
Human   260 SADQALDRFAMKKFYDDKVSALMQPSQKRYVQFLSGLLSGSV---KMNASPLFLHFVILHGTPNF 321

  Fly   209 -SESSCVQNLGMVECSISVLHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIPVSGDVKFELTKK 272
             :...|...|.:.: ::..::.|...|..|:.        .....:.|:|:..:.|||..:...|
Human   322 DTGGVCRPFLKLYQ-AMQPVYTSGIYNVGPEN--------PSRICIVIEPAQLLKGDVMVKCYHK 377

  Fly   273 ----SPDKIICHFWLNTFFVRNYSPCESDGTVNKYIHTLSKSEIDDVHKDSEHKRFSEEFKISIV 333
                :...:|.....:|            |.|..|.....|.::|:..||.   ||.:..|:.:|
Human   378 KYRSATRDVIFRLQFHT------------GAVQGYGLVFGKEDLDNASKDD---RFPDYGKVELV 427

  Fly   334 FEAENFSNDVQAEASEKERNEN--VLNFERSD-------YDSLSPNCYAEKKV----------LT 379
            |.|    ...:.:.||...|::  ::::..:|       |::||    |:.:|          |.
Human   428 FSA----TPEKIQGSEHLYNDHGVIVDYNTTDPLIRWDSYENLS----ADGEVLHTQGPVDGSLY 484

  Fly   380 AIVNDNTTKSQTI----------ETLDHKDIVTKIQYDT--STNSKNTSTACKRKQPNSKTLL-- 430
            |.|...::....|          .:.||.|....:..|:  ||.|..|....:|..|.::..|
Human   485 AKVRKKSSSDPGIPGGPQAIPATNSPDHSDHTLSVSSDSGHSTASARTDKTEERLAPGTRRGLSA 549

  Fly   431 -------------------PSLNDSTKEEIKRN----------HIFNQPSIK--KTDLI--KWQN 462
                               .||.:.|....|.:          |:....::|  :||::  :..:
Human   550 QEKAELDQLLSGFGLEDPGSSLKEMTDARSKYSGTRHVVPAQVHVNGDAALKDRETDILDDEMPH 614

  Fly   463 SEVHITSD--TRSINENKNINYNSYITCKQSSPKFNCGTEDG 502
            .::|....  |.|.:|.....:....||.:||.  |....||
Human   615 HDLHSVDSLGTLSSSEGPQSAHLGPFTCHKSSQ--NSLLSDG 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_477422.2	PTP_PTEN	31..189	CDD:350359	56/159 (35%)
		PTEN_C2	196..335	CDD:463081	26/152 (17%)
TNS3	XP_047276679.1	C1_TNS3_v	49..104	CDD:410439
		PTP_tensin-3	138..296	CDD:350409	56/159 (35%)
		PTEN_C2	303..429	CDD:463081	25/149 (17%)
		PHA03247	<754..1188	CDD:223021
		SH2_Tensin_like	1298..1414	CDD:198181
		PTB_tensin	1438..1569	CDD:269924