Protein Alignment Pten and TNS3

DIOPT Version :9

• Sequence 1: NP_001162933.1
• Gene: Pten / 43991
• FlyBaseID: FBgn0026379
• Length: 514
• Species: Drosophila melanogaster
• Sequence 2: XP_011513778.1
• Gene: TNS3 / 64759
• HGNCID: 21616
• Length: 1561
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 133/562 - (23%)
• Similarity: 234/562 - (41%)
• Gaps: 123/562 - (21%)

  Fly    25 EKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKF 89
            |:|:.||||||.:.|||:.:||....|....| |::|.::|:..|..:|.:.|| ||:.||:.|.
Human   118 EEGHGLDLTYITERIIAVSFPAGCSEESYLHN-LQEVTRMLKSKHGDNYLVLNL-SEKRYDLTKL 180

  Fly    90 RGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKK 154
            ..::....:.:.:.|.::.:...|...:.||..:..:||.:||:.||||.|.:|.:|:.|:.:..
Human   181 NPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNLQHVVVIHCRGGKGRIGVVISSYMHFTNVSA 245

  Fly   155 SADEALAWYDEKRTKDRK--GVTIPSQRRYVQYFSKLVCSSVPYSKVSLNVCEIRF--------- 208
            |||:||..:..|:..|.|  .:..|||:||||:.|.|:..||   |::.:...:.|
Human   246 SADQALDRFAMKKFYDDKVSALMQPSQKRYVQFLSGLLSGSV---KMNASPLFLHFVILHGTPNF 307

  Fly   209 -SESSCVQNLGMVECSISVLHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIPVSGDVKFELTKK 272
             :...|...|.:.: ::..::.|...|..|:.        .....:.|:|:..:.|||..:...|
Human   308 DTGGVCRPFLKLYQ-AMQPVYTSGIYNVGPEN--------PSRICIVIEPAQLLKGDVMVKCYHK 363

  Fly   273 ----SPDKIICHFWLNTFFVRNYSPCESDGTVNKYIHTLSKSEIDDVHKDSEHKRFSEEFKISIV 333
                :...:|.....:|            |.|..|.....|.::|:..||.   ||.:..|:.:|
Human   364 KYRSATRDVIFRLQFHT------------GAVQGYGLVFGKEDLDNASKDD---RFPDYGKVELV 413

  Fly   334 FEAENFSNDVQAEASEKERNEN--VLNFERSD-------YDSLSPNCYAEKKV----------LT 379
            |.|    ...:.:.||...|::  ::::..:|       |::||    |:.:|          |.
Human   414 FSA----TPEKIQGSEHLYNDHGVIVDYNTTDPLIRWDSYENLS----ADGEVLHTQGPVDGSLY 470

  Fly   380 AIVNDNTTKSQTI----------ETLDHKDIVTKIQYDT--STNSKNTSTACKRKQPNSKTLL-- 430
            |.|...::....|          .:.||.|....:..|:  ||.|..|....:|..|.::..|
Human   471 AKVRKKSSSDPGIPGGPQAIPATNSPDHSDHTLSVSSDSGHSTASARTDKTEERLAPGTRRGLSA 535

  Fly   431 -------------------PSLNDSTKEEIKRN----------HIFNQPSIK--KTDLI--KWQN 462
                               .||.:.|....|.:          |:....::|  :||::  :..:
Human   536 QEKAELDQLLSGFGLEDPGSSLKEMTDARSKYSGTRHVVPAQVHVNGDAALKDRETDILDDEMPH 600

  Fly   463 SEVHITSD--TRSINENKNINYNSYITCKQSSPKFNCGTEDG 502
            .::|....  |.|.:|.....:....||.:||.  |....||
Human   601 HDLHSVDSLGTLSSSEGPQSAHLGPFTCHKSSQ--NSLLSDG 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	33/108 (31%)
		PTEN_C2	196..335	CDD:287393	26/152 (17%)
TNS3	XP_011513778.1	C1_1	37..84	CDD:278556
		PTPc_motif	188..302	CDD:214649	37/116 (32%)
		PTEN_C2	289..415	CDD:287393	25/149 (17%)
		SH2_Tensin_like	1284..1400	CDD:198181
		PTB_tensin	1424..1555	CDD:269924

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810