DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pten and tns2b

DIOPT Version :9

Sequence 1:	NP_001162933.1	Gene:	Pten / 43991	FlyBaseID:	FBgn0026379	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	XP_021327488.1	Gene:	tns2b / 565809	ZFINID:	ZDB-GENE-101001-5	Length:	1445	Species:	Danio rerio

Alignment Length:	526	Identity:	124/526 - (23%)
Similarity:	219/526 - (41%)	Gaps:	104/526 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MSNVIRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQH 72
            |..|:.|::...        ||.|||||.:.||::.|.: |..|..:...|:.|..:|:..|...
Zfish   113 METVMENLMGSH--------YDFDLTYITERIISVLYQS-DLDEQSYSANLKVVAPMLKSKHQDK 168

  Fly    73 YKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKG 137
            :.:.|| ||:.:|:.:...:|..:.:.|.:.|.::.|...|..::.||..|.:|||.:|||..||
Zfish   169 FLLINL-SEKRHDICRLNPKVEEFGWPDLHAPPLDKICAVCKTMENWLNSDPNNVVVLHCKGNKG 232

  Fly   138 RTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRK--GVTIPSQRRYVQYFSKLVCSSVPYSKVS 200
            :||.::.||:.:|.|...||:||:....::..:.|  ...:|||.||:.||:.|:..|:..:...
Zfish   233 KTGVIVAAYMHYSKISAGADQALSTVAMRKFCEDKISSFILPSQNRYIYYFAGLLSGSIKMNSSP 297

  Fly   201 LNVCEIRFSESSCVQNLG------MVECSISVLHDSATENAKPDRLKTLPIDFQKSFVLTIKPSI 259
            |.:.:|....|...|:.|      .:..|:.:::.|...:.:....|||.::        |:|::
Zfish   298 LFLHQIHVPVSPNYQSGGGYAPFLKIYQSLQLVYSSGKYDIQGPNSKTLCVN--------IEPAL 354

  Fly   260 PVSGDVKFELTKKSPDKIICHFWLNTFFVRNYSPCESDGTVNKYIHTLS---------KSEIDDV 315
            .:.||:   |.|       |:..|:       ..|:.:.......||.|         |.|:|..
Zfish   355 LLKGDI---LVK-------CYHRLS-------DVCKRECVFRVQFHTCSVHGSQLAFGKGELDHA 402

  Fly   316 HKDSEHKRFSEEFKISIVFEAENFSNDVQAEASEKERNENVLNFERSDYDSLSP----NCYAEKK 376
            ..|.   ||..:..:.::     ||...|....:...||..::   :||.|..|    :.|.
Zfish   403 CTDD---RFPSDATVELL-----FSTGPQRRGGDVPGNEPGVS---ADYGSTDPVVRWDSYE--- 453

  Fly   377 VLTAIVNDNTTKSQTIETLDHKDIVTKIQYDTSTNSKNTSTACKRKQPNSKTLLP-SLNDSTKEE 440
                  |.|.....::|.:.|    |:...|.|..::   ...:|.|.:|.:..| |:..||...
Zfish   454 ------NFNLHHEDSVEDISH----TRGPLDGSLYAQ---VKKRRAQGSSPSRCPTSIKPSTYSP 505

  Fly   441 IKRN-----HIFNQPSIKKTDLIKWQNSEVHIT---SDTRSINENKNINYNSYITCKQSSPKFNC 497
            ...:     |:..||.....|..:...:...:|   .:.|..:||:..:..:.|
Zfish   506 THSSSTSPIHLSVQPLSLSKDTSRSSAAPESLTPLPREKREKDENRERHRETAI----------- 559

  Fly   498 GTEDGE 503
             .:|||
Zfish   560 -LDDGE 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	35/108 (32%)
Pten	NP_001162933.1	PTEN_C2	196..335	CDD:287393	28/153 (18%)
tns2b	XP_021327488.1	C1_1	45..91	CDD:278556
		PTPc_motif	191..304	CDD:214649	36/112 (32%)
		PTEN_C2	293..420	CDD:313607	29/159 (18%)
		SH2_Tensin_like	1168..1283	CDD:198181
		PTB_tensin	1307..1438	CDD:269924
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900