DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pten and tns1a

DIOPT Version :9

Sequence 1:	NP_001162933.1	Gene:	Pten / 43991	FlyBaseID:	FBgn0026379	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	XP_009300586.1	Gene:	tns1a / 565181	ZFINID:	ZDB-GENE-120215-32	Length:	1688	Species:	Danio rerio

Alignment Length:	448	Identity:	116/448 - (25%)
Similarity:	194/448 - (43%)	Gaps:	79/448 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 EKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKF 89
            |:..::||.||.:.|||:.:|...: |..:...|.:|..:|...|.|||.:.|| |||.:|:.|.
Zfish   126 EENNEVDLLYITERIIALSFPGGTE-ENKYSVHLREVTSMLRSKHQQHYLMLNL-SERRHDITKQ 188

  Fly    90 RGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKK 154
            ..||..:.:.||:.|.::.|...|..:|.||..|..|||.:|.|...||||.::.||:.:|.|..
Zfish   189 NPRVLDFGWPDHHAPALDKICSICKAMDTWLNADPHNVVVLHNKGNWGRTGVVVGAYMHYSNISA 253

  Fly   155 SADEALAWYDEKRTKDRKGVTI--PSQRRYVQYFSKLVCSSVPYSKVSLNVCEIRFSESSCVQNL 217
            |||:||..:..||..:.|.:.:  ||||||||||:.|:...:..:...|.:..:........:::
Zfish   254 SADQALDRFAMKRFYEDKAMPVGQPSQRRYVQYFAGLLSGHIKINNKPLFLHHVIMHGIPNFESI 318

  Fly   218 G------MVECSISVLHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIPVSGDVKFELTKK---S 273
            |      .:..::..::.|...|.|.|.        ..|..:||:|.:.:.||:..:...|   :
Zfish   319 GGCRPFLKIYQAMQPVYTSGIYNVKGDS--------HTSICITIEPGLLLKGDILLKCYHKRYQN 375

  Fly   274 PDKIICHFWLNTFFVRNYSPCESDGTVNKYIHTL----SKSEIDDVHKDSEHKRFSEEFKISIVF 334
            |.:       :..|...:..|.        :|.|    :|:::||..|..|  ||.|..|:..:|
Zfish   376 PSR-------DVIFRVQFHTCA--------LHNLALVFTKNDLDDTFKADE--RFPEYGKVEFIF 423

  Fly   335 E--------AENFSN--DVQAEASEKE---RNENVLNFERSDYD----------SLSPNCYA--- 373
            .        .::..|  .|..:.:.::   |.::..||.|...|          .:..|.||
Zfish   424 SFDPEKIKGLDHLQNGPSVSVDYNTQDPLIRWDSYENFNRRCEDVNVDAAHTQGPIDGNLYARVQ 488

  Fly   374 EKKVLTAIVNDNTTKSQ-----------TIETLDHKDIVTKIQYDTSTNSKNTSTACK 420
            :|..|..||..|...|.           .:...:|:..........|::|.|::.:.|
Zfish   489 KKNSLEGIVPANGAYSTDRVPPVAEHALPLPVANHQLPAADHALSVSSDSGNSTASVK 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	43/108 (40%)
Pten	NP_001162933.1	PTEN_C2	196..335	CDD:287393	27/151 (18%)
tns1a	XP_009300586.1	C1	<55..88	CDD:197519
		PTPc_motif	188..>257	CDD:214649	26/68 (38%)
		PTEN_C2	297..424	CDD:287393	27/151 (18%)
		SH2_Tensin_like	1404..1519	CDD:198181
		PTB_tensin	1553..1683	CDD:269924
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810