DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pten and ptenb

DIOPT Version :9

Sequence 1:	NP_001162933.1	Gene:	Pten / 43991	FlyBaseID:	FBgn0026379	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_001001822.1	Gene:	ptenb / 368415	ZFINID:	ZDB-GENE-030616-47	Length:	399	Species:	Danio rerio

Alignment Length:	437	Identity:	167/437 - (38%)
Similarity:	238/437 - (54%)	Gaps:	78/437 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MSNVIRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQH 72
            |:.:|:..||:.:.||:|.|:|||||||..||||||:|| ::|||::||.::||.:.|:..|..|
Zfish     1 MAAIIKEFVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPA-ERLEGVYRNNIDDVVRFLDSKHKDH 64

  Fly    73 YKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKG 137
            |||||||:||.||.|||..|||.|||:|||||.:|||:.||.|:|.||.|:.::|.|:|||||||
Zfish    65 YKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDKWLSENDNHVAAIHCKAGKG 129

  Fly   138 RTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSSVPYSKVSLN 202
            |||.||||||:..|..|.|.|||.:|||.||:|:||||||||||||.|:|.|:.:.:.|..|:|.
Zfish   130 RTGVMICAYLLHRGKFKKAQEALDFYDEVRTRDKKGVTIPSQRRYVYYYSYLLRNKLEYKPVALL 194

  Fly   203 VCEI------RFSESSCVQNLGMVECSISVLHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIPV 261
            ..::      .||..:|.....:.:..:.: |.|...:.:.:         :|.........:||
Zfish   195 FHKMVFETVPMFSGGTCNPQFVVYQLKVKI-HTSNPAHTRRE---------EKYMFFEFPQPLPV 249

  Fly   262 SGDVKFELTKK-----SPDKIICHFWLNTFFV----RNYSPCESDGTV----------------N 301
            .||:|.|...|     ..:|:. |||:||||:    .:....|:.|.|                :
Zfish   250 CGDIKVEFFHKQNKMMKKEKMF-HFWVNTFFIPGSEESTEKVENGGLVKDLDGIQTAERGENDKD 313

  Fly   302 KYIHTLSKSEIDDVHKDSEHKRFSEEFKISIVFEAENFSNDVQAEASEKERNENVLNFERSDYDS 366
            ..|.||||:::|..:||..::.||..||:.:.|               .:..|...|.|.|...|
Zfish   314 YLILTLSKTDLDKANKDKANRYFSPNFKVKMFF---------------TKTVEEPSNSEASTSTS 363

  Fly   367 LSPNCYAEKKVLTAIVNDN---------TTKSQTIETLDHKDIVTKI 404
            ::|:           |:||         ||.|........::.:||:
Zfish   364 VTPD-----------VSDNEPDHYRYSDTTDSDPENEQYDEEQITKV 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	67/108 (62%)
Pten	NP_001162933.1	PTEN_C2	196..335	CDD:287393	39/169 (23%)
ptenb	NP_001001822.1	PTPc_motif	92..182	CDD:214649	59/89 (66%)
ptenb	NP_001001822.1	PTEN_C2	188..348	CDD:287393	40/185 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595215
Domainoid	1	1.000	116	1.000	Domainoid score	I5928
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H265
Inparanoid	1	1.050	273	1.000	Inparanoid score	I2955
OMA	1	1.010	-	-		QHG52467
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001369
OrthoInspector	1	1.000	-	-		otm24669
orthoMCL	1	0.900	-	-		OOG6_100936
Panther	1	1.100	-	-	O	PTHR12305
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1027
SonicParanoid	1	1.000	-	-		X965
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.890