DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pten and Tns3

DIOPT Version :9

Sequence 1:	NP_001162933.1	Gene:	Pten / 43991	FlyBaseID:	FBgn0026379	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	XP_008768557.1	Gene:	Tns3 / 360980	RGDID:	1564174	Length:	1562	Species:	Rattus norvegicus

Alignment Length:	571	Identity:	134/571 - (23%)
Similarity:	232/571 - (40%)	Gaps:	141/571 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 EKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKF 89
            |..::|||||:.:.|||:.:||....|. :.:.|::|.::|:..|..:|.:.|| ||:.||:.|.
  Rat   120 EDSHELDLTYVTERIIAVSFPASCSEES-YLHSLQEVTRMLKSKHGDNYLVLNL-SEKRYDLTKL 182

  Fly    90 RGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKK 154
            ..::....:.:.:.|.::.:...|...:.||..|..:||.:||:.||||.|.:|.:|:.|:.:..
  Rat   183 NPKIMDVGWPELHAPPLDKMCTICKAQESWLNSDPQHVVVIHCRGGKGRIGVVISSYMHFTNVSA 247

  Fly   155 SADEALAWYDEKRTKDRK--GVTIPSQRRYVQYFSKLVCSSVPYSKVSLNVCEIRF--------- 208
            |||:||..:..|:..|.|  .:..|||:||||:.|.|:..:|   |::.:...:.|
  Rat   248 SADQALDRFAMKKFYDDKVSALMEPSQKRYVQFLSGLLSGAV---KMNASPLFLHFVILHGAPSF 309

  Fly   209 -SESSCVQNLGMVECS----ISVLHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIPVSGDV--- 265
             :..:|...|.:.:..    .|.:::..:||  |.|::           :.|:|:..:.||:
  Rat   310 DTGGACRPFLKLYQAMQPVYTSGIYNVGSEN--PSRIR-----------IAIEPAQLLKGDIMVK 361

  Fly   266 ----KFELTKKSPDKIICHFWLNTFFVRNYSPCESDGTVNKYIHTLSKSEIDDVHKDSEHKRFSE 326
                ||   :.:...:|.....:|            |.|..|.....|.|:|...||.   ||.:
  Rat   362 CYHKKF---RSATRDVIFRLQFHT------------GAVQGYGLLFGKEELDSACKDD---RFPD 408

  Fly   327 EFKISIVFEAENFSNDVQAEASEKERNENVLNFERS---DYDSLSP--------NCYAEKKV--- 377
            ..||.:||.|          ..||.:....|..::.   ||::..|        |..|:.:|
  Rat   409 YGKIELVFSA----------TPEKIQGSEHLYSDQGVTVDYNTADPLIRWDSYENMSADGEVLHT 463

  Fly   378 -------LTAIVNDNTTKSQTI----------ETLDHKDIVTKIQYDT--STNSKNTSTACKRKQ 423
                   |.|.|...:.....|          .:.||.|....:..|:  ||.|..|....:|:.
  Rat   464 QGPVDGSLYAKVRKKSASDSGIPSSPQGMPATSSPDHGDHTLSVSSDSGHSTASARTDKTEERQT 528

  Fly   424 PNSKT-LLP-------------SLNDS----------------TKEEIKRN-HIFNQPSIK--KT 455
            |.::. |.|             .|.||                |:..:... |:....::|  :|
  Rat   529 PGARRGLSPQEKAELDQLLSGFGLEDSANSHKDMTDMRSKYSGTRHVVPAQVHVNGDAALKDRET 593

  Fly   456 DLI--KWQNSEVHITSD--TRSINENKNINYNSYITCKQSSPKFNCGTEDG 502
            |::  :..:.::|....  |.|.:|.....:.....|.:||.  |....||
  Rat   594 DILDDEMPHHDLHSVDSLGTLSSSEGPQSTHLGPFACLKSSQ--NSLLSDG 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	34/108 (31%)
Pten	NP_001162933.1	PTEN_C2	196..335	CDD:287393	30/159 (19%)
Tns3	XP_008768557.1	C1	39..85	CDD:237996
		PTPc_DSPc	190..304	CDD:214469	37/116 (32%)
		PTEN_C2	291..417	CDD:287393	29/156 (19%)
		SH2_Tensin_like	1285..1401	CDD:198181
		PTB_tensin	1425..1556	CDD:269924
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810