DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pten and Dusp11

DIOPT Version :9

Sequence 1:	NP_001162933.1	Gene:	Pten / 43991	FlyBaseID:	FBgn0026379	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_001020821.1	Gene:	Dusp11 / 297412	RGDID:	1307038	Length:	326	Species:	Rattus norvegicus

Alignment Length:	193	Identity:	46/193 - (23%)
Similarity:	77/193 - (39%)	Gaps:	48/193 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 DVFKLLEENHAQ------------HYKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRF 112
            |:|..::|.:.:            :||:.:|....||......|         |..|....|.:|
  Rat    73 DLFNKIQEQNEELGLIIDLTYTQRYYKVEDLPKTISYIKILTVG---------HQVPDSGTIFQF 128

  Fly   113 CSDVDMWLKEDSSN--VVAVHCKAGKGRTGTMICAYLV-FSGIKKSADEALAWYDEKRTKDRKGV 174
            .|.|..:||.:.:|  ::.|||..|..|||.:||.||: ..|::  .|:|:..::..|     |.
  Rat   129 KSAVKEFLKRNKNNDKLIGVHCTHGLNRTGYLICRYLIDVEGMR--PDDAIELFNRCR-----GH 186

  Fly   175 TIPSQRRYVQYFSKLVCSSVPYSKVSLNVCEIRFSESSCVQNLGMVECSISVLHDSATENAKP 237
            .|..| .|::...|.               .:|.::::.....|.:|.|..:.....|.| ||
  Rat   187 CIERQ-NYIENLQKR---------------RVRKNQNASASRSGGLEDSAHLTEQVHTTN-KP 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	32/121 (26%)
Pten	NP_001162933.1	PTEN_C2	196..335	CDD:287393	8/42 (19%)
Dusp11	NP_001020821.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		PTPc	77..194	CDD:304379	34/133 (26%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:O75319	151..156		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..258		8/49 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910