DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pten and GAK

DIOPT Version :9

Sequence 1:	NP_001162933.1	Gene:	Pten / 43991	FlyBaseID:	FBgn0026379	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	XP_011511727.1	Gene:	GAK / 2580	HGNCID:	4113	Length:	1355	Species:	Homo sapiens

Alignment Length:	459	Identity:	109/459 - (23%)
Similarity:	189/459 - (41%)	Gaps:	109/459 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SNVIRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHY 73
            |.||::|.:      ..|| |||::||...|..|.:|| :.:|...:|.:|||...|:..|..||
Human   394 SKVIQSVAN------YAKG-DLDISYITSRIAVMSFPA-EGVESALKNNIEDVRLFLDSKHPGHY 450

  Fly    74 KIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGR 138
            .:||| |.|:|..::|..||:...:.....|.:..:...|.::..||::|..||..|||..|:..
Human   451 AVYNL-SPRTYRPSRFHNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAA 514

  Fly   139 TGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSS--VPYSKVSL 201
            :...:|::|.|..:..:|:.|:..:..||..  .|:. ||.:||::|...:|...  .|:||..|
Human   515 SAVAVCSFLCFCRLFSTAEAAVYMFSMKRCP--PGIW-PSHKRYIEYMCDMVAEEPITPHSKPIL 576

  Fly   202 NVCEIR---------FSE--SSCVQNLGMVECSISVLHDS-ATENAKPDRLKTLPIDFQKSFVLT 254
                :|         ||:  |.|     ...|.:.|..:. |:.:.:.|:::...|:..|:   .
Human   577 ----VRAVVMTPVPLFSKQRSGC-----RPFCEVYVGDERVASTSQEYDKMRDFKIEDGKA---V 629

  Fly   255 IKPSIPVSGDVKF-----------ELTKKSPDKIICHFWLNTFFV-RNYSPCESDGTVNKYIHTL 307
            |...:.|.|||..           .|..|.....:.....:|.|| ||       .|..|:
Human   630 IPLGVTVQGDVLIVIYHARSTLGGRLQAKMASMKMFQIQFHTGFVPRN-------ATTVKF---- 683

  Fly   308 SKSEID--DVHKDSEHKRFSEEFKISIVFEAENFSNDVQAEASEKERNENVLNFERSDYDSLSPN 370
            :|.::|  |:     .:::.:.|::::         :|:.|..::...| ...:|.|....|:|
Human   684 AKYDLDACDI-----QEKYPDLFQVNL---------EVEVEPRDRPSRE-APPWENSSMRGLNP- 732

  Fly   371 CYAEKKVLTAIVNDNTTKSQTIETLDHKDIVTKI-------------QYDTSTNSKNTSTACKRK 422
                 |:|.:            ...:.:||::|.             |||....|..........
Human   733 -----KILFS------------SREEQQDILSKFGKPELPRQPGSTAQYDAGAGSPEAEPTDSDS 780

  Fly   423 QPNS 426
            .|:|
Human   781 PPSS 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	32/108 (30%)
Pten	NP_001162933.1	PTEN_C2	196..335	CDD:287393	32/164 (20%)
GAK	XP_011511727.1	STKc_GAK	39..320	CDD:270938
		S_TKc	41..309	CDD:214567
		PTEN_C2	570..708	CDD:287393	33/174 (19%)
		DnaJ	<1304..1348	CDD:99751
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810