DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pten and ptn1

DIOPT Version :9

Sequence 1:	NP_001162933.1	Gene:	Pten / 43991	FlyBaseID:	FBgn0026379	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_596312.1	Gene:	ptn1 / 2541101	PomBaseID:	SPBC609.02	Length:	348	Species:	Schizosaccharomyces pombe

Alignment Length:	362	Identity:	113/362 - (31%)
Similarity:	168/362 - (46%)	Gaps:	54/362 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 NVIRNVVSKKRIRYKEKGYD-----LDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENH 69
            |::|:|||:.|...|::..:     ||:.||...:|||..||.. :..|:||...||||.|....
pombe     2 NILRSVVSRGRKGLKQEKVNRSFAYLDMVYITSKVIAMSTPAAG-IHKLYRNDELDVFKYLTTQL 65

  Fly    70 AQHYKIYNLCSERS-YDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCK 133
            ..::.:.|||:|.: |.:..|:..|..|.|.|||||.:..:.....::|...:......:.||||
pombe    66 KDNWILLNLCAEETVYHLELFKPNVINYGFQDHNPPPLLFLWAIVMNMDALFQTQPLLTLVVHCK 130

  Fly   134 AGKGRTGTMICAYLV-FSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSSVP-Y 196
            ||||||||:||:||| |.|:  :|.::|..|.|||.....|:||.||.|||.|..  :....| |
pombe   131 AGKGRTGTVICSYLVAFGGL--TAKQSLELYTEKRMVRGHGLTISSQIRYVYYIE--ILKQFPNY 191

  Fly   197 SK-VSLNVCEIRFSESSCVQNLGMVECSISVLHD-SATENAKPDRL-KTLPIDFQKSFVLTIKPS 258
            .| |..|.....|....|: |:......|..||. |...|..|..| |:..|   .|..::||..
pombe   192 LKAVEFNTGTTFFKSFKCL-NIKKNSSLILSLHAFSKGRNINPVALWKSSDI---SSHNVSIKEG 252

  Fly   259 IPVSG----------DVKFELTKKS----PDKIICHFWLNTFF----VRNYSPCESDGTVNKYIH 305
            ..:.|          |:...:.:|.    |..:.|  |.:|.|    |...:.......:|.::.
pombe   253 KRIWGIQCNLETSEKDLLLRVERKGQFYFPSSVQC--WFHTHFQPMLVEYTNGINFQQGINSFLQ 315

  Fly   306 -----TLSKSEIDDVHKDSEHKRFSEEF--KISIVFE 335
                 :.|.||:|       :.|.|:.|  :::||:|
pombe   316 GQQSISFSWSEMD-------NSRRSDPFFEQLTIVYE 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	43/110 (39%)
Pten	NP_001162933.1	PTEN_C2	196..335	CDD:287393	38/166 (23%)
ptn1	NP_596312.1	CDC14	15..201	CDD:225297	72/190 (38%)
ptn1	NP_596312.1	PTPc	<78..179	CDD:304379	42/102 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	50	1.000	Domainoid score	I3411
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001369
OrthoInspector	1	1.000	-	-		oto101288
orthoMCL	1	0.900	-	-		OOG6_100936
Panther	1	1.100	-	-	O	PTHR12305
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1027
SonicParanoid	1	1.000	-	-		X965
TreeFam	0	0.000	Not matched by this tool.
	9	8.840