DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pten and Gak

DIOPT Version :9

Sequence 1:	NP_001162933.1	Gene:	Pten / 43991	FlyBaseID:	FBgn0026379	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_705797.1	Gene:	Gak / 231580	MGIID:	2442153	Length:	1305	Species:	Mus musculus

Alignment Length:	501	Identity:	121/501 - (24%)
Similarity:	202/501 - (40%)	Gaps:	105/501 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SNVIRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHY 73
            |.||::|.:      ..|| |||::||...|..|.:|| :.:|...:|.:|||...|:..|..||
Mouse   392 SKVIQSVAN------YAKG-DLDISYITSRIAVMSFPA-EGVESAIKNNIEDVRMFLDAKHPGHY 448

  Fly    74 KIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGR 138
            .:||| |.|.|..:||..||....:.....|.:..:...|..:..||:||..||..|||..|:..
Mouse   449 AVYNL-SPRIYRASKFHNRVTECGWAVRRAPHLHSLYTLCRSMHAWLREDHRNVCVVHCMDGRAA 512

  Fly   139 TGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSS--VPYSKVSL 201
            :...:||:|.|..:..:|:.|:..:..||..  .|:. ||.:||::|...:|...  .|:||..|
Mouse   513 SAVAVCAFLCFCRLFSTAEAAVYMFSMKRCP--PGIW-PSHKRYIEYVCDMVAEEPITPHSKPML 574

  Fly   202 NVCEIR-----FSESSCVQNLGMVECSISVLHDSATENAKP-DRLKTLPIDFQKSFVLTIKPSIP 260
            ....:.     ||:.   :|.....|.:.|..:..|..::. ||:|...|:..|:   .|...:.
Mouse   575 VKSVVMTPVPLFSKQ---RNGCRPFCEVYVGEERVTTTSQEYDRMKEFKIEDGKA---VIPLGVT 633

  Fly   261 VSGDVKF-----------ELTKKSPDKIICHFWLNTFFV-RNYSPCESDGTVNKYIHTLSKSEID 313
            |.|||..           .|..|.....:.....:|.|| ||       .|..|:    :|.::|
Mouse   634 VQGDVLIIIYHARATLGGRLQAKMASMKMFQIQFHTGFVPRN-------ATTVKF----AKYDLD 687

  Fly   314 --DVHKDSEHKRFSEEFKISIVFEAENFSNDVQAEASEKERNENVLNFERSDYDSLSPNCYAEKK 376
              |:     .:::.:.|::::         :|:.|..::...| ...:|.:....|:|.
Mouse   688 ACDI-----QEKYPDLFQVNL---------EVEVEPRDRPSRE-APPWENTSLRGLNPK------ 731

  Fly   377 VLTAIVNDNTTKSQTIETLDHKDIVTKIQYDTSTNSKNTSTACKRKQPNSKTLLPSLNDSTKEEI 441
                |:..|..:.|        ||::|.......           :||.|.....:...|.:.||
Mouse   732 ----ILFSNREEQQ--------DILSKFGKPELP-----------RQPGSTAQYDAEAGSPEAEI 773

  Fly   442 KRNHIFNQPSIKKTD------LIKWQNSEVHITS-DTRSINENKNI 480
            ..:   :.|....||      .:.||..:...|. |..|..|::::
Mouse   774 TES---DSPQSSSTDTNHFLHTLDWQEEKEPETGLDNTSPKESQSV 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	35/108 (32%)
Pten	NP_001162933.1	PTEN_C2	196..335	CDD:287393	32/158 (20%)
Gak	NP_705797.1	STKc_GAK	39..320	CDD:270938
		S_TKc	41..311	CDD:214567
		PTEN_C2	568..706	CDD:287393	33/168 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	707..732		5/35 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	747..854		15/84 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1037..1139
		DnaJ	<1253..1298	CDD:99751
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810