DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pten and Tns2

DIOPT Version :9

Sequence 1:	NP_001162933.1	Gene:	Pten / 43991	FlyBaseID:	FBgn0026379	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	XP_030104299.1	Gene:	Tns2 / 209039	MGIID:	2387586	Length:	1408	Species:	Mus musculus

Alignment Length:	358	Identity:	92/358 - (25%)
Similarity:	168/358 - (46%)	Gaps:	47/358 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 EKGYDLDLTYINDNIIAMGYPA-PDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAK 88
            |:.:||||||:.:.|:|..:|| ||  |...|..|.::..:|:..|...|.::|| ||:.:|:.:
Mouse   127 ERRWDLDLTYVTERILAAAFPARPD--EQRHRGHLRELAHVLQSKHRDKYLLFNL-SEKRHDLTR 188

  Fly    89 FRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIK 153
            ...:|..:.:.:.:.|.::.:...|..::.||..|..:||.::||..||:.|.::.||:.:|.|.
Mouse   189 LNPKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQHVVVLYCKGSKGKLGVIVSAYMHYSKIS 253

  Fly   154 KSADEALAWYDEKRTKDRKGVT--IPSQRRYVQYFSKLVCSSVPYSKVSLNVCEI------RFSE 210
            ..||:|||....::..:.|..|  .|||||||.|||.|:..|:..:...|.:..:      .|..
Mouse   254 AGADQALATLTMRKFCEDKVATELQPSQRRYVSYFSGLLSGSIRMNSSPLFLHYVFVPVLPAFEP 318

  Fly   211 SSCVQNLGMVECSISVLHDSATEN-AKPDRLKTLPIDFQKSFVLTIKPSIPVSGDVKFELTKK-- 272
            ::..|....:..|:.:::.|.... |.|.         .:...::::|::.:.|||......|
Mouse   319 NTGFQPFLKIYQSMQLVYTSGVYRIAGPG---------PQQLCISLEPALLLKGDVMVTCYHKGG 374

  Fly   273 -SPDKIICHFWLNTFFVRNYSPCESDGTVNKYIHTLSKSEIDDVHKDSEHKRFSEEFKISIVFEA 336
             ..|:.:       .|...:..|    |::....|..|.::|:...|   :||  .|:.|:.|.
Mouse   375 QGTDRTL-------VFRVQFHTC----TIHGSRLTFPKDQLDEAWAD---ERF--PFQASVEFV- 422

  Fly   337 ENFSNDVQAEASEKERNENVLNFERSDYDSLSP 369
              ||:..:.......||:..::.   ||::..|
Mouse   423 --FSSSPEKVKGNTPRNDPSVSV---DYNTTEP 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	31/108 (29%)
Pten	NP_001162933.1	PTEN_C2	196..335	CDD:287393	24/148 (16%)
Tns2	XP_030104299.1	C1	33..80	CDD:237996
		PTP_DSP_cys	133..291	CDD:391942	55/160 (34%)
		PTEN_C2	298..425	CDD:371036	26/154 (17%)
		PHA03247	<726..1124	CDD:223021
		SH2_Tensin_like	1135..1248	CDD:198181
		PTB_tensin	1272..1404	CDD:269924
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810