DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pten and Pten

DIOPT Version :9

Sequence 1:	NP_001162933.1	Gene:	Pten / 43991	FlyBaseID:	FBgn0026379	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_032986.1	Gene:	Pten / 19211	MGIID:	109583	Length:	403	Species:	Mus musculus

Alignment Length:	405	Identity:	168/405 - (41%)
Similarity:	232/405 - (57%)	Gaps:	61/405 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MSNVIRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQH 72
            |:.:|:.:||:.:.||:|.|:|||||||..||||||:|| ::|||::||.::||.:.|:..|..|
Mouse     1 MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPA-ERLEGVYRNNIDDVVRFLDSKHKNH 64

  Fly    73 YKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKG 137
            |||||||:||.||.|||..|||.|||:|||||.:|||:.||.|:|.||.||.::|.|:|||||||
Mouse    65 YKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKG 129

  Fly   138 RTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSSVPYSKVSLN 202
            |||.||||||:..|....|.|||.:|.|.||:|:||||||||||||.|:|.|:.:.:.|..|:|.
Mouse   130 RTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALL 194

  Fly   203 VCEI------RFSESSCVQNLGMVECSISV-LHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIP 260
            ..::      .||..:|  |...|.|.:.| ::.|   |:.|.|.:      .|.........:|
Mouse   195 FHKMMFETIPMFSGGTC--NPQFVVCQLKVKIYSS---NSGPTRRE------DKFMYFEFPQPLP 248

  Fly   261 VSGDVKFELTKK-----SPDKIICHFWLNTFF----------VRNYSPCE-----------SDGT 299
            |.||:|.|...|     ..||:. |||:||||          |.|.|.|:           :|..
Mouse   249 VCGDIKVEFFHKQNKMLKKDKMF-HFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADND 312

  Fly   300 VNKYIHTLSKSEIDDVHKDSEHKRFSEEFKISIVF----------EAENFSNDVQAEASEKERNE 354
            ....:.||:|:::|..:||..::.||..||:.:.|          ||.: |..|..:.|:.|.:
Mouse   313 KEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASS-STSVTPDVSDNEPD- 375

  Fly   355 NVLNFERSDYDSLSP 369
               ::..||.....|
Mouse   376 ---HYRYSDTTDSDP 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	66/108 (61%)
Pten	NP_001162933.1	PTEN_C2	196..335	CDD:287393	47/181 (26%)
Pten	NP_032986.1	PTP_PTEN	24..181	CDD:350359	100/156 (64%)
		PTEN_C2	188..349	CDD:402161	53/203 (26%)
		Required for interaction with NOP53. /evidence=ECO:0000250\|UniProtKB:P60484	338..348		2/9 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	352..403		3/11 (27%)
		PDZ domain-binding. /evidence=ECO:0000250	401..403
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849519
Domainoid	1	1.000	118	1.000	Domainoid score	I5866
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H265
Inparanoid	1	1.050	284	1.000	Inparanoid score	I2848
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52467
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001369
OrthoInspector	1	1.000	-	-		oto93632
orthoMCL	1	0.900	-	-		OOG6_100936
Panther	1	1.100	-	-	LDO	PTHR12305
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1027
SonicParanoid	1	1.000	-	-		X965
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790