DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pten and tns-1

DIOPT Version :9

Sequence 1:	NP_001162933.1	Gene:	Pten / 43991	FlyBaseID:	FBgn0026379	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_491637.2	Gene:	tns-1 / 172215	WormBaseID:	WBGene00006508	Length:	1354	Species:	Caenorhabditis elegans

Alignment Length:	465	Identity:	102/465 - (21%)
Similarity:	188/465 - (40%)	Gaps:	97/465 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SLMSNVIRN-------VVSKKRIRYKEKGYD----LDLTYINDNIIAMGYPAPDKLEGLFRNRLE 59
            |..||...|       .:|:.::|.|:|..|    :.:.||...:|.:...: :..|..|...|.
Worm    10 SRKSNKYNNEAGYEVYTISEDQLRLKQKMKDRKEGVQVEYITSRLIVLSCTS-ETSERKFVESLL 73

  Fly    60 DVFKLLEENHAQHYKIYNLCSERSYDVAKFRGRVAVYPF--DDHNPPTIELIQRFCSDVDMWLKE 122
            ...:.::..|.:|.:::|: |:|.:|::   ..:...||  .....|::|.:...|.::|.|:.|
Worm    74 KASQQIQNAHNKHIRVWNV-SQRRHDIS---SSLDAIPFGWPSETAPSLEKLCTICKNLDQWMLE 134

  Fly   123 DSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDR----KGVTIPSQRRYV 183
            ...|:..:.||.|..|...::.|::.|:.|..:.|.....:..:|..:|    .|.  ||.:||:
Worm   135 HPLNIAVIFCKGGLERCAIVVNAFMRFNAISATDDSVDDRFSMQRFSERFLGPDGP--PSYKRYL 197

  Fly   184 QYFSKLVCS--SVPYSKVSLNVCEIRFSESSCVQNLGMVECSISVLHDSATENAKPDRLKTLPID 246
            .|||.|:..  ||....:.|:...:.|.|...| .|.:.|..:.|...           ||:.::
Worm   198 GYFSSLLSGRISVNSDPLYLHNIILTFFEPINV-FLKIYERLVPVYQS-----------KTVALN 250

  Fly   247 FQKSFVLTIKPSIPVSGDVKFE--LTKKSP-DKIICHF--WLNTFFVRNYSPCESDGTVNKYIHT 306
              ||....:..|:.:.||:.|:  :...|| ....|.|  .|||..:..: |..|:|.....:|
Worm   251 --KSSKFEMDGSLKLRGDIFFKCIVAASSPGSSTRCLFTCQLNTCALELH-PINSEGYSVVRLH- 311

  Fly   307 LSKSEIDDVHKDSEHKRFSEEFKISIVFEAEN-----FSNDVQAEASEKERNENVLNFERSDYDS 366
              |.|:|.:..|   |:......:.:|....:     .:..||:..|...||.:...||.:.
Worm   312 --KEELDLIFND---KKIDNRVTVELVVSHTSGPTTIATAAVQSVHSLLPRNNSYETFELAQ--- 368

  Fly   367 LSPNCYAEKKVLTAIVNDNTTKSQTIETLDHKDIVTKIQYDTSTNSKNTSTACKRKQPNSKTLLP 431
                            :|.|.:|:           .:::|         |...|:...:||:..|
Worm   369 ----------------DDETNRSR-----------LEVEY---------SEIRKKSTKSSKSANP 397

  Fly   432 SLNDSTKEEI 441
             :|::.:||:
Worm   398 -INNNQEEEM 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	24/110 (22%)
Pten	NP_001162933.1	PTEN_C2	196..335	CDD:287393	32/143 (22%)
tns-1	NP_491637.2	PTP_tensin	46..203	CDD:350358	39/163 (24%)
		SH2_Tensin_like	1079..1189	CDD:198181
		PTB_tensin	1207..1348	CDD:269924
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910