DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pten and AgaP_AGAP003715

DIOPT Version :9

Sequence 1:	NP_001162933.1	Gene:	Pten / 43991	FlyBaseID:	FBgn0026379	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	XP_310244.7	Gene:	AgaP_AGAP003715 / 1271448	VectorBaseID:	AGAP003715	Length:	1287	Species:	Anopheles gambiae

Alignment Length:	407	Identity:	97/407 - (23%)
Similarity:	164/407 - (40%)	Gaps:	97/407 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SNVIRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDK-LEGLFR-NRLEDVFKLLEENHAQ 71
            |:.:...|.:..:|     .|||::||...|:.|  |.|.: :|..:| |.::|| ||..::..|
Mosquito   447 SSKVMQTVQQSIVR-----TDLDMSYITQRILVM--PCPSEGIESAYRTNNIDDV-KLFLDSRYQ 503

  Fly    72 HYK--IYNLCSE----------RSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDS 124
            ..|  :|||...          |:.|....   .|..|......|.:..:.....|:..:|..|.
Mosquito   504 PTKLSVYNLVGRNGCPRLPPPVRTVDAGFI---YAPAPQQGGKAPVLTGLYSLVEDIYGFLSADP 565

  Fly   125 SNVVAVHC-KAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSK 188
            ..||.|.. ..|:....|::||.||::.:....::|:..:..|||.....   ||:.||:.|...
Mosquito   566 KTVVIVQSPDGGRALAATVVCALLVYASLVTEPEDAMQMFAIKRTPPNMR---PSELRYLYYLGD 627

  Fly   189 LVCSSVPY-------SKVSLNVCEI-RFSESSCVQNLGMVECSISVLHDSATENAKPDRLKTLPI 245
            :| .|||:       :.|||.|..: |.:::       ...|.:.|      |.|..||.....:
Mosquito   628 IV-RSVPHLPHYKPVTLVSLAVTPVPRMTKA-------RDGCRMYV------EVATADRTVFCTL 678

  Fly   246 -DFQKSFV-------LTIKPSIPVSGDVKFELTKK--------SPDKI-ICHFWLNTFFVRNYSP 293
             |:::..:       :.:..::.|.|||...|...        .|..: ||....:|.|:.
Mosquito   679 QDYERMRLYHTSEGKIALAMNVTVCGDVTISLYHARNALGGMGRPQGLKICQLQFHTGFIP---- 739

  Fly   294 CESDGTVNKYIHTLSKSEIDDVHKDSEHKRFSEEFKISI-VFEAEN--------------FSNDV 343
             |.:..:|     ..::|:|:| .|.||  ..::|.::: ||..::              .|.|.
Mosquito   740 -EEETLIN-----YDRAELDEV-PDLEH--VPQKFSVALSVFVGDSERPPATQPPWRTPKASRDP 795

  Fly   344 QA-EASEKERNENVLNF 359
            :. .||:.|..|||.||
Mosquito   796 RTLFASQLEYEENVDNF 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	27/121 (22%)
Pten	NP_001162933.1	PTEN_C2	196..335	CDD:287393	32/164 (20%)
AgaP_AGAP003715	XP_310244.7	PKc_like	35..314	CDD:304357
		S_TKc	37..305	CDD:214567
		YppG	<381..460	CDD:290883	2/12 (17%)
		PTEN_C2	636..767	CDD:287393	31/156 (20%)
		Rox3	<1071..1126	CDD:285797
		DnaJ	<1232..1272	CDD:197617
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810