DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pten and tns2

DIOPT Version :9

Sequence 1:	NP_001162933.1	Gene:	Pten / 43991	FlyBaseID:	FBgn0026379	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	XP_002936689.3	Gene:	tns2 / 100486792	XenbaseID:	XB-GENE-988669	Length:	1850	Species:	Xenopus tropicalis

Alignment Length:	525	Identity:	122/525 - (23%)
Similarity:	237/525 - (45%)	Gaps:	88/525 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANTISL----MSNVIRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDV 61
            |.:|.||    .|::.||......|   ::.||||||||.:.||::.:|. :..|..:|..|.:|
Frog    99 MGSTKSLNIKQRSSLPRNFSLDHVI---QRSYDLDLTYITERIISVFFPT-NLEEQRYRANLREV 159

  Fly    62 FKLLEENHAQHYKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSN 126
            ..:|...|...|.::|| |.:.:|:.|...::..:.:.|.:.|.:::|...|..::.||.:|..:
Frog   160 ATMLRSKHEDKYLLFNL-SRKRHDIGKLNPKIQDFFWPDCHAPPLDVICSICKAMEAWLAQDPQH 223

  Fly   127 VVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYD-EKRTKDRKGVTI-PSQRRYVQYFSKL 189
            ||.:|||..:|:||.:|.:|:.:|.:..|||:||:... .|..:|:..|:: ||||||:.||..|
Frog   224 VVVLHCKGNQGKTGVVIASYMHYSKVSASADQALSTLAMRKFCEDKVSVSLHPSQRRYINYFGGL 288

  Fly   190 VCSSVPYSKVSLNVCEIRFSESSCVQNLG------MVECSISVLHDSATENAKPDRLKTLPIDFQ 248
            :..::..|...|::..:.......:|..|      .:..|:.:::.|...::...   |.|  .:
Frog   289 LSGTIKISSDMLSLQCVLLPVIPALQTDGGFCPFLKIYQSMQLVYTSGIYSSLGG---TTP--QK 348

  Fly   249 KSFVLTIKPSIPVSGDVKFEL----TKKSPDKIICHFWLNTFFVRNYSPCESDGTVNKYIHTLSK 309
            :...::::|::.:.||:..:.    .|....:::.....:|..:.|...|            .||
Frog   349 RQLRISLEPALLLKGDIMVKCYHKRCKPHEREVLFRVQFHTCTIHNTHLC------------FSK 401

  Fly   310 SEIDDVHKDSEHKRFSEEFKISIVFEA--------ENFSND-------------VQAEASEK--- 350
            .::|....|.   ||.|:..:..:|..        |.|..|             |:.::.|.
Frog   402 DQLDCAFTDD---RFPEDASVEFLFSTGQDKAKGREVFCKDPDVSVDYDITDPLVRYDSYENINM 463

  Fly   351 --ERNENVLNFERSDYDSLSPNCYAE-KKVLTAIVNDNTTKSQTIETLDHKDIVTKIQYDTSTNS 412
              |.|...|:..|...|.   :.||. ||.:|.:.:.|.:..|      |..:::     .|::|
Frog   464 IYEDNLEDLSHTRGPLDG---SLYARVKKKITPVTSSNGSPEQ------HGRLLS-----VSSDS 514

  Fly   413 KNTSTACKRKQPNSKTLLPSLNDSTKEEIKRNHIFNQPSIKKTDLIKWQNSEV--HITSDTRSIN 475
            .::|...:|.:...:..||:..:  :|:::|  :.....:|.....:...|:|  |....|:::|
Frog   515 GHSSAPTERLEETPQKSLPTATE--REDLER--LLGGFGVKAKQEAEPNYSQVLKHEEVATQNLN 575

  Fly   476 ENKNI 480
            :.:|:
Frog   576 QRQNL 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	33/109 (30%)
Pten	NP_001162933.1	PTEN_C2	196..335	CDD:287393	22/148 (15%)
tns2	XP_002936689.3	C1_TNS2	30..82	CDD:410437
		PTP_tensin-2	130..288	CDD:350410	54/159 (34%)
		PTEN_C2	300..425	CDD:402161	22/144 (15%)
		PHA03247	<859..1170	CDD:223021
		Herpes_BLLF1	<1040..1527	CDD:282904
		SH2_Tensin_like	1575..1690	CDD:198181
		PTB_tensin	1714..1845	CDD:269924
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910