Protein Alignment Pten and tns1

DIOPT Version :10

• Sequence 1: NP_477422.2
• Gene: Pten / 43991
• FlyBaseID: FBgn0026379
• Length: 514
• Species: Drosophila melanogaster
• Sequence 2: XP_031749629.1
• Gene: tns1 / 100216306
• XenbaseID: XB-GENE-957068
• Length: 1866
• Species: Xenopus tropicalis
• Alignment Length: 528
• Identity: 129/528 - (24%)
• Similarity: 224/528 - (42%)
• Gaps: 101/528 - (19%)

  Fly    13 RNVVSKKR-------IRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHA 70
            |:..|::|       |...|...:||||||.:.||::.:....: |..|...|::|..:|:..|.
 Frog   122 RSTQSRRRPSRSISLIHAMEDSCELDLTYITERIISVTFSTGTE-EPTFCRNLKEVAHMLKSKHG 185

  Fly    71 QHYKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAG 135
            .:|.|:|| |||.:|::|...:|..:.:.|.:.|.:|.:...|..:|.||..|..|||.:|.|..
 Frog   186 DNYLIFNL-SERRHDISKLHSKVLDFGWPDLHAPALEKVCSICKAMDTWLNADPHNVVVIHNKGN 249

  Fly   136 KGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTI--PSQRRYVQYFSKLVCSSVPYSK 198
            :||||.:|.||:.:|.|..|||:||..:..:|..:.|.:.:  |||:||:.|||.|:..::..:.
 Frog   250 RGRTGVVIAAYMHYSNISASADQALDRFAMRRFYEDKVLPVAQPSQKRYINYFSGLLSGAMKMNS 314

  Fly   199 VSLNVCEIRF-------SESSCVQNLGMVECSISVLHDSATENAKPDRLKTLPIDFQKSFVLTIK 256
            ..|.:..:..       |:..|...|.:.: ::..::.|...|.:.|.        |.|..:||:
 Frog   315 KPLFLHHVIMHGIPNFESKGGCRPFLKIYQ-AMQPVYTSGIYNVQGDS--------QTSICITIE 370

  Fly   257 PSIPVSGDVKFELTKK---SPDKIICHFWLNTFFVRNYSPCESDGTVNKYIHTL----SKSEIDD 314
            |.:.:.||:..:...|   ||.:       :..|...:..|.        ||.|    .|.::|:
 Frog   371 PGLLLKGDILLKCYHKKFRSPTR-------DVIFRVQFHTCA--------IHDLGIVFGKEDLDE 420

  Fly   315 VHKDSEHKRFSEEFKISIVFE--------AENFSN--DVQAEASEKE---RNENVLNFERSDYDS 366
            ..||   :||.|..|:..||.        .|:..|  .|..:.:..:   |.::..||.....||
 Frog   421 AFKD---ERFPEYGKVEFVFSYGPEKIQGMEHLENGPSVSVDYNTSDPLIRWDSYDNFNVHREDS 482

  Fly   367 LSP----------NCYAEKKVLTAIVNDNTTKS-QTIETL--------DHKDIVTKIQYDTSTNS 412
            |..          :.||:.|     ..|:|..| .|:...        :|.:....:..|:..::
 Frog   483 LEEVGHTQGPLDGSLYAKVK-----KKDSTNGSTSTVNASGIPLSAAPNHIEHTLSVSSDSGNST 542

  Fly   413 KNTSTACKRKQPNSKTLLPSLNDSTKEEIKR------------NHIFNQPSIKKTDLIKWQNSEV 465
            .:|.|....:|..:......|....|:|::|            .|..|..:.....::....::|
 Frog   543 ASTKTDKTDEQVATAAANQGLTPEEKQELERLLSGFGLETEGQMHNLNPGTSAAAAMLHVVPAQV 607

  Fly   466 HITSDTRS 473
            |:..:..|
 Frog   608 HVNGERTS 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_477422.2	PTP_PTEN	31..189	CDD:350359	60/159 (38%)
		PTEN_C2	196..335	CDD:463081	31/152 (20%)
tns1	XP_031749629.1	C1	42..98	CDD:412127
		PTP_tensin-1	147..305	CDD:350408	60/159 (38%)
		PTEN_C2	312..438	CDD:463081	31/152 (20%)
		PHA03247	<904..1435	CDD:223021
		SH2_Tensin_like	1593..1708	CDD:198181
		PTB_tensin	1730..1861	CDD:269924